Function of hormone- and osmo-sensor in the central regulation of osmolality

2008 Fiscal Year Self-evaluation Report

• Project Area: Molecular interaction and modal shift of cellular sensors
• Project/Area Number: 18077006
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: UETA Yoichi University of Occupational and Environmental Health, Japan, 医学部, 教授 (10232745)
• Project Period (FY): 2006 – 2010
• Keywords: セルセンサー / 浸透圧 / バゾプレッシン

Research Abstract

細胞は外部環境の変化に生体が適応・生存するためにその感知機構(セルセンサー)を発達させてきた。本研究課題では、外部環境の変化の一つとして浸透圧変化に着目し、浸透圧変化が引き起こすホルモン分泌を感知するホルモンセンサーと浸透圧変化そのものを細胞が感知する浸透圧センサーとの機能連関の解明を目的とした。具体的には、中枢性浸透圧調節を担う液性因子の主役であるバゾプレッシン系および飲水行動調節に焦点を当てて研究を推進している。

Research Products

• [Journal Article] Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats (2009)
  • Author(s): Suzuki, H. Onaka, T. Kasai, M. Kawasaki, M. Ohnishi, H. Otsubo, H. Saito, T. Hashimoto, H. Yokoyama, T. Fujihara, H. Dayanithi, G. Murphy, D. Nakamura, T. & Ueta Y.
  • Journal Title: Journal of Neuroendocrinology 21(3) Pages: 183-190
  • Peer Reviewed
• [Journal Article] Brain - derived neurotrophic factor inhibits spontaneous inhibitory postsynaptic currents in the rat supraoptic nucleus (2009)
  • Author(s): Ohbuchi, T. Yokoyama, T. Saito, T. Hashimoto, H. Suzuki, H. Otsubo, H. Fujihara, H. Suzuki, H. & Ueta, Y.
  • Journal Title: Brain Research 1258 Pages: 34-42
  • Peer Reviewed
• [Journal Article] Chronic osmotic stimuli increase salusin-β-like immunoreactivity in the rat hypothalamo-neurohypophyseal system : possible involvement of salusin- on [Ca2+]i increase and neurohypophyseal hormone release from the axon terminals (2008)
  • Author(s): Saito, T. Dayanithi, G. Saito, J. Onaka, T. Urabe, T. Watanabe, TX. Hashimoto, H. Yokoyama, T. Fujihara, H. Yokota, A. Nishizawa, S. Hirata, Y. & Ueta, Y.
  • Journal Title: Journal of Neuroendocrinology 20(2) Pages: 207-219
  • Peer Reviewed
• [Journal Article] The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somato/dendritic peptide release. (2008)
  • Author(s): Tobin, A.V. Bull, P.M. Arunachalam, S. O'Carroll, A.-M. Ueta, Y. & Ludwig, M.
  • Journal Title: Endocrinology 149(12) Pages: 6136-6145
  • Peer Reviewed
• [Journal Article] Effects of the short chain sugar Acid 2-buten-4-olide on the hypothalamo-pituitary-adrenal axis in normal and adjuvant-induced arthritic rats (2007)
  • Author(s): Kawasaki M, Onaka T, Saito J, Hashimoto H, Suzuki H, Otsubo H, Fujihara H, Okimoto N, Ohnishi H, Nakamura T, Ueta Y.
  • Journal Title: Journal of Neuroendocrinology 19(1) Pages: 54-65
  • Peer Reviewed
• [Journal Article] Centrally and peripherally administered ghrelin potently inhibits water intake in rats. (2007)
  • Author(s): Hashimoto, H. Fujihara, H. Kawasaki, M. Saito, T. Shibata, M. Otsubo, H. Takei, Y. & Ueta, Y.
  • Journal Title: Endocrinology 148(4) Pages: 1638-1647
  • Peer Reviewed
• [Journal Article] Downregulation of prolactin-releasing peptide gene expression in the hypothalamus and brainstem of diabetic rats (2007)
  • Author(s): Mera, T. Fujihara, H. Saito, J. Kawasaki, M. Hashimoto, H. Saito, T. Shibata, M. Onaka, T. Tanaka, Y. Oka, T. Tsuji, S. Ueta, Y.
  • Journal Title: Peptides 28(8) Pages: 1596-1604
  • Peer Reviewed
• [Presentation] 中枢性浸透圧調節とTRPチャネル (2008)
  • Author(s): 上田 陽一
  • Organizer: 第61回日本自律神経学会総会(シンポジウム)
  • Place of Presentation: 横浜
  • Year and Date: 20081106-07
• [Presentation] TRPチャネルと中枢性浸透圧調節 (2008)
  • Author(s): 上田 陽一
  • Organizer: 第81回日本内分泌学会学術総会(シンポジウム)
  • Place of Presentation: 青森
  • Year and Date: 20080516-18
• [Presentation] ラット視索上核大細胞性神経分泌ニューロンへの興奮性シナプス入力に対するグレリンの効果 (2008)
  • Author(s): 横山徹、齋藤健、大淵豊明、橋本弘史、鈴木仁士、大坪広樹、藤原広明、長友敏寿、上田陽一
  • Organizer: 第85回日本生理学会大会
  • Place of Presentation: 東京
  • Year and Date: 20080325-20080327
• [Presentation] ラットにおける中枢性体液調節:ストレス・ペプチド・浸透圧感受性 (2008)
  • Author(s): 上田 陽一
  • Organizer: 第33回日本比較内分泌学会大会(シンポジウム)
  • Place of Presentation: 広島
  • Year and Date: 2008-12-05
• [Remarks] ホームページ
  • URL: http://www.nips.ac.jp/cellsensor/NL_1_6.html