2022 Fiscal Year Final Research Report
Identification and characterization of brain disorder-related singularity cells by whole-brain imaging
| Project Area | Singularity biology |
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| Project/Area Number |
18H05416
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中澤 敬信 東京農業大学, 生命科学部, 教授 (00447335)
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| Project Period (FY) |
2018-06-29 – 2023-03-31
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| Keywords | シンギュラリティ細胞 / 自閉スペクトラム症 / ストレス |
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| Outline of Final Research Achievements |
The aim of this study was to elucidate the singularity phenomenon in brain disorders, such as mental illnesses, which occur when the activity of a specific subset of brain cells explosively spreads to a wide brain region, leading to widespread changes in neuronal activity. We developed methodologies to comprehensively observe and analyze a vast number of brain cells, as well as neuronal activation reporter systems and foundational technologies related to induced pluripotent stem cells. Furthermore, we revealed the significance of abnormal activity in an exceedingly small number of neurons within the brains in stress-exposed mice and a mouse model of autism spectrum disorder, as it relates to the expression of behavioral abnormalities.
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| Free Research Field |
神経薬理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、創薬の標的としての脳疾患におけるシンギュラリティ現象の同定が可能になったことである。精神疾患分野では、新規分子病態を標的とする創薬が難航しており、既存薬の治療効果も限定的である。本研究の実施により創薬につながる新しい分子病態情報を得ることができ、急務である中枢神経系創薬の推進に貢献することが期待される点で、本研究は社会的要求が著しく高いといえる。
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