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2022 Fiscal Year Final Research Report

Design of Molecular Engine Using Baacteriophage T4

Planned Research

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Project AreaMolecular Engine: Design of Autonomous Functions through Energy Conversion
Project/Area Number 18H05421
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo Institute of Technology

Principal Investigator

Ueno Takafumi  東京工業大学, 生命理工学院, 教授 (70332179)

Co-Investigator(Kenkyū-buntansha) 金丸 周司  東京工業大学, 生命理工学院, 助教 (50376951)
Project Period (FY) 2018-06-29 – 2023-03-31
KeywordsバクテリオファージT4 / 生体超分子 / 高速AFM
Outline of Final Research Achievements

In nature, various proteins form specific assembly structures spontaneously. In this study, as a protein needle precision design for dynamic supramolecular assemblies, we realized a protein needle with precisely controlled functions as a molecular engine based on the crystal structure of gp5, experimental results from HSAFM, and molecular dynamics calculations. To achieve precise assembly of gp5 on a two-dimensional surface, we modified the protein to have an anisotropic assembly structure. As a result, we constructed a model from theoretical calculations and elucidated the mechanism of new assembly formation by understanding the experimental results of high-speed AFM using mathematical modeling.

Free Research Field

生体関連化学

Academic Significance and Societal Importance of the Research Achievements

本研究の特色は、巨大生体超分子の部品蛋白質を基盤とした発動分子を作成することによって、部品蛋白質の機能を発動分子の合成に利用し、本来の機能を拡張する点にある。天然の蛋白質集合体がもつ発動分子としての特徴を使いこなすことができれば、蛋白質ー蛋白質相互作用が関与する様々な生体分子の動きの機能を理解することが可能となり、蛋白質集合体を化学ツールとする革新的な分子操作技術の開発や、生命現象に内在する発動分子科学の基礎原理の理解へと展開し、細胞生物学やケミカルバイオロジー研究にも大きなインパクトを与える新しい生体機能化学分野が拓かれると確信する。

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Published: 2024-01-30  

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