Fabrication and integration of nano-structured optical devices for strong photons-molecules coupling fields

2010 Fiscal Year Final Research Report

• Project Area: Strong Photons-Molecules Coupling Fields for Chemical Reactions
• Project/Area Number: 19049016
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: NISHII Junji National Institute of Advanced Industrial Science and Technology, 電子科学研究所, 教授 (60357697)
• Co-Investigator(Kenkyū-buntansha): TAWA Keiko 産業技術総合研究所, 健康工学研究部門, 主任研究員 (80344109) ; KINTAKA Kenji 産業技術総合研究所, ユビキタスエネルギー研究部門, 主任研究員 (50356911)
• Project Period (FY): 2007 – 2010
• Keywords: 表面プラズモン共鳴 / 蛍光顕微鏡 / 増強蛍光 / ナノインプリント

Research Abstract

Fluorescence microscopy using grating-coupled surface plasmon resonance (GC-SPR) was investigated for sensitive observation of proteins labeled by fluorescence dyes. Surface-relief periodic structures coated with a silver film were designed and fabricated for high-efficiency excitation of GC-SPR with unpolarized light, which gave a fluorescence image 100 times brighter than that on a slide glass.

Research Products

• [Journal Article] Sensitive bioimaging in microfluidic channels on the plasmonic substrate : Application of an enhanced fluorescence based on the reverse coupling mode (2011)
  • Author(s): Keiko Tawa, Xiaoctiang Cui, Kenji Kintaka, Junji Nishii, Kenichi Morigaki
  • Journal Title: Journal of Photochemistry and Photobiology A : Chemistry, accepted
  • Peer Reviewed
• [Journal Article] An application of a plasmonic chip with enhanced fluorescence to a simple biosensor with extended dynamic range (2011)
  • Author(s): Keiko Tawa, Yoshiki Yokota, Kenji Kintaka, Junji Nishii, Takahiko Nakaoki
  • Journal Title: Sensors and Actuators B : Chemical, accepted
  • Peer Reviewed
• [Journal Article] Surface profile dependence of the photon coupling efficiency and enhanced fluorescence in the grating-coupled surface plasmon resonance (2010)
  • Author(s): Hironobu Hori, Keiko Tawa, Kenji Kintaka, Junji Nishii, Yoshiro Tatsu
  • Journal Title: J. Appl. Phys. 107巻 Pages: 114702-1-114702-6
  • Peer Reviewed
• [Journal Article] Tailored plasmonic gratings for enhanced fluorescence detection and microscopic imaging (2010)
  • Author(s): Xiaogiang Cui, Keiko Tawa, Hironobu Hori, Junji Nishii
  • Journal Title: Adv. Func. Mat. 20巻 Pages: 546-553
  • Peer Reviewed
• [Journal Article] Enhanced fluorescence microscopic imaging by plasmonic nanostructures : from a 1D grating to a 2D nanohole array (2010)
  • Author(s): Xiaogiang Cui, Keiko Tawa, Kenji Kintaka, Junji Nishii
  • Journal Title: Adv. Func. Mat. 20巻 Pages: 945-950
  • Peer Reviewed
• [Journal Article] Duty ratio-dependent fluorescence enhancement through surface Plasmon resonance in Ag-coated gratings (2009)
  • Author(s): X.Cui, K.Tawa, H.Hori, J.Nishii
  • Journal Title: Appl. Phys. Lett. 95巻 Pages: 133117/1-133117/3
  • Peer Reviewed
• [Journal Article] Sensitive detection of a pseudo-polyrotaxane ultrathin film by SPR and QCM-D methods (2009)
  • Author(s): K.Tawa, N.Kuboyama, Saleh A.Ahmed, M.Tanaka, T.Nakaoki
  • Journal Title: Sensors and Actutators B : Chemical 138巻 Pages: 126-133
  • Peer Reviewed
• [Journal Article] Application of Grating Substrate Fabricated by Nanoimprint Lithography to Surface Plasmon Field-Enhanced Fluorescence Microscopy and Study of Its Optimum Structure (2009)
  • Author(s): Naoko Akashi, Keiko Tawa, Yoshiro Tatsu, Kenji Kintaka, Junji Nishii
  • Journal Title: Jpn. J. Appl. Phys. 48巻 Pages: 062002-1/6
  • Peer Reviewed
• [Journal Article] Nano-textured metallic surfaces for optical sensing and detection applications (2009)
  • Author(s): Yukie Yokota, Kosei Ueno, Saulius Juodkazis, Vygantas Mizeikis, Naoki Murazawa, Hiroaki Misawa, Haruya Kasa, Kenji Kintaka, Junji Nishii
  • Journal Title: J. Photochem. Photobiol. A : Chem. 207巻 Pages: 126-134
  • Peer Reviewed
• [Journal Article] Influence of Groove depth and Surface Profile on Fluorescence Enhancement by Grating Coupled Surface Plasmon Resonance (2009)
  • Author(s): HironobuHori, Keiko Tawa, Kenji Kintaka, Junji Nishii, Yoshiro Tatsu
  • Journal Title: Optical Review 16巻 Pages: 216-221
  • Peer Reviewed
• [Journal Article] Optical microscopic observation of fluorescence enhanced by grating-coupled surface plasmon resonance (2008)
  • Author(s): K.Tawa, H.Hori, K.Kintaka, K.Kiyosue, Y.Tatsu, J.Nishii
  • Journal Title: Opt. Express 16-13巻 Pages: 9781-9790
  • Peer Reviewed
• [Presentation] 高感度バイオセンシングを目指したプラズモニックチップの作製 (2011)
  • Author(s): 田和圭子、横田佳樹、東洋輔
  • Organizer: デザインバイオニクス講演会
  • Place of Presentation: 阪大中之島センター(大阪府)
  • Year and Date: 2011-03-29
• [Presentation] Sensitive and rapid detection of antigens on the plasmonic substrate with bispecific antibodies against antigen and ZnO surface, Oral (invited) (2010)
  • Author(s): Keiko Tawa, Mitsuo Umetsu, Takamitsu Hattori, Izumi Kumagai
  • Organizer: 20th MRS-Japan Academic Symposium
  • Place of Presentation: 横浜市(神奈川県)
  • Year and Date: 2010-12-22
• [Presentation] 10pM-antigens detection on the plasmonic substrate with bispecific antibodies against antigen and ZnO surface, (invited) (2010)
  • Author(s): Keiko Tawa, Mitsuo Umetsu, Takamitsu Hattori, Izumi Kumagai
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu(Hawaii, USA).
  • Year and Date: 2010-12-16
• [Presentation] Sensitive Fluorescence Microscopic Imaging with Plasmonic Substrate, Poster (2010)
  • Author(s): Keiko Tawa, Xiaoqiang Cui, Kenji Kintaka, Junji Nishii
  • Organizer: The international conference on nanophotonics 2010
  • Place of Presentation: つくば(茨城県)
  • Year and Date: 2010-06-01
• [Presentation] 100 Times-Enhanced Fluorescence Detected on a Metal-coated Grating Biochip (2010)
  • Author(s): Keiko Tawa, Junji Nishii
  • Organizer: Oral, 7th International Conference on Optics-Photonics Design & Fabrication (ODF'10)
  • Place of Presentation: 横浜(神奈川県)
  • Year and Date: 2010-04-20
• [Presentation] 100-Fold Enhancement of Fluorescence Imaging by Two-Dimensional-Grating-Coupled Surface Plasmon Resonance (2009)
  • Author(s): Kenji Kintaka, Xiaoqiang Cui, Keiko Tawa, Junji Nishii
  • Organizer: Advances in Optical Materials (AIOM) part of the Fall OSA Optics & Photonics Congress
  • Place of Presentation: サンノゼ(アメリカ)
  • Year and Date: 2009-10-15
• [Presentation] Development of enhanced fluorescence imaging microscopy with a metal coated grating for biologicalapplications (2009)
  • Author(s): K.Tawa, J.Nishii, X.Q.Cui, K.Kintaka
  • Organizer: International symposium on advances in nanostructure-enhanced photochemical reactions and photoenergy conversion
  • Place of Presentation: Leuven(ベルギー)
  • Year and Date: 2009-07-16
• [Presentation] 格子カップリング表面プラズモン共鳴場を用いたタンパク質の増強蛍光検出 (2009)
  • Author(s): 田和圭子, 堀博伸, 金高健二, 達吉郎, 西井準治
  • Organizer: 応用物理学関係連合講演会
  • Place of Presentation: 筑波大学(茨城県)
  • Year and Date: 2009-03-30
• [Presentation] The Detection of Antigen-Antibody Recognition on an Array Chip by Surface Plasmon Field-Enhanced Fluorescence Imaging (SPFI) (2008)
  • Author(s): Yuji Nishizawa, Keiko Tawa, Takahisa Taguchi, Kazuyuki Kiyosu, Takahiko Nakaoki
  • Organizer: IUMRS
  • Place of Presentation: 名古屋(愛知県)
  • Year and Date: 2008-12-10
• [Presentation] Fluorescence Microscopy using Subwavelength Grating Coupled Surface Plasmon Resonance (2008)
  • Author(s): Junji Nishii, Kenji Kinatka, Naoko Akashi, Hironobu Hori, Keiko Tawa
  • Organizer: The 2nd Japan-Taiwan Joint Symposium on Organized naomaterials and Nanostructures Related to Photoscience
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2008-11-05
• [Presentation] Antigen-Antibody Interaction on a Chip Observed by Surface Plasmon Field-Enhanced Fluorescence Microscopy (SPFM) (2007)
  • Author(s): Y.Nishizawa, K.Tawa, K.Kiyosue, T.Taguchi, T.Nakaoki
  • Organizer: The 10th Pacific Polymer Conference (PPC10)
  • Place of Presentation: 神戸市(兵庫県)
  • Year and Date: 2007-12-05
• [Book] プラズモンナノ材料の新技術 (2009)
  • Author(s): 田和圭子, 西井準治
  • Total Pages: 228-236
  • Publisher: シーエムシー出版
• [Remarks] ホームページ
  • URL: http://www.es.hokudai.ac.jp/labo/photocontrol/
• [Patent(Industrial Property Rights)] 微小発光素子 (2010)
  • Inventor(s): 宮下徳治、三ツ石方也、森田晋平、田和圭子、西井準治
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 特許,特願2010-180209
  • Filing Date: 2010-08-11
• [Patent(Industrial Property Rights)] プラズモン共鳴蛍光を用いた生体分子相互作用検出装置及び検出方法 (2009)
  • Inventor(s): 田和圭子, 田口隆久
  • Industrial Property Rights Holder: 産業技術総合研究所
  • Industrial Property Number: 特許,第4370383
  • Acquisition Date: 2009-09-11
• [Patent(Industrial Property Rights)] 周期構造を有するマイクロプレートおよびそれを用いた表面プラズモン励起増強蛍光顕微鏡または蛍光マイクロプレートリーダー (2008)
  • Inventor(s): 田和圭子、西井準治、金高健二、堀博伸、達吉郎
  • Industrial Property Rights Holder: 産業技術総合研究所
  • Industrial Property Number: 特許,特願2008-268112
  • Filing Date: 2008-10-17