2010 Fiscal Year Final Research Report
Basic study for the synthesis of photo-driven molecular machines
| Project Area | New Horizons of Photochromism: Customized Molecular Design and Novel Applications |
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| Project/Area Number |
19050013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Hokkaido University (2008-2010)
National Institute of Advanced Industrial Science and Technology (2007) |
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Principal Investigator |
TAMAOKI Nobuyuki Hokkaido University, 電子科学研究所, 教授 (00344218)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Haruhisa 独立行政法人産業技術総合研究所, ナノテクノロジー研究部門, 研究員 (80356352)
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| Project Period (FY) |
2007 – 2010
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| Keywords | 分子機械 / 分子モーター / 光スイッチ / 自己組織化 / 高分子合成 |
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| Research Abstract |
We investigated the possibility of photo-control of the action or the speed in synthetic or biological molecular machines. In the synthetic molecular machines we synthesized compounds cyclically connected a photoisomerizable azobenzene and an aromatic ring as a rotor unit via spacers. By tuning the spacer lengths and the bulkiness of the rotor unit, it is for the first time accomplished to demonstrate the complete ON-OFF switching of the intra-molecular rotation of the rotor by the action of lights. In the kinesin/microtubuline system as one of motor proteins, it was demonstrated that reversible photo-regulations of the motility velocity were possible by the introduction of azobenzene moiety on surface of the substrate, in an inhibitor, or in the ATP structure.
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