Spectroscopic study of non-destructive ionization process for mass spectrometry

2011 Fiscal Year Final Research Report

• Project Area: Molecular Science for Supra Functional Systems ? Development of Advanced Methods for Exploring Elementary Process
• Project/Area Number: 19056008
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: FUJINO Tatsuya 首都大学東京, 理工学研究科, 准教授 (20360638)
• Project Period (FY): 2007 – 2011
• Keywords: 質量分析法 / MALDI法 / プロトン移動 / 時間分解分光

Research Abstract

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry allows us to know molecular weight of compounds. Although sample preparation and operation of instruments are quite easy compared with other soft ionization methods, there are several drawbacks at the same time. In the study, we investigated desorption and ionization mechanisms by spectroscopic methods, and we developed useful techniques to overcome such drawbacks in MALDI.

Research Products

• [Journal Article] Desorption Dynamics of Tetracene-Doped Anthracene Crystals Studied by Femtosecond Time-Resolved Mass Spectrometry (2012)
  • Author(s): Y. Minegishi, D. Morimoto, J. Matsumoto, H. Shiromaru, K. Hashimoto, *T. Fujino
  • Journal Title: J. Phys. Chem. Volume: C 116 Pages: 3059-3064
  • Peer Reviewed
• [Journal Article] Mass spectrometry of low-molecular-weight compounds with 2,4,6-trihydroxyacetophenone and 2,4-dihydroxyacetophenone in ・- cyclodex- trin (2010)
  • Author(s): T. Fujita, *T. Fujino, K. Hirabayashi, T. Korenaga
  • Journal Title: Anal. Sci. Volume: 26 Pages: 743-748
  • Peer Reviewed
• [Journal Article] Pronounced Selectivity in MALDI Mass Spectrometry with 2,4,6-Trihydroxyacetophenone on Zeolite Surface: Intensity Enhancement of Protonated Peptides and Suppression of Matrix-related Ions (2010)
  • Author(s): Y. Komori, H. Shima, *T. Fujino, J. N. Kondo, K. Hashimoto, T. Korenaga
  • Journal Title: J. Phys. Chem. Volume: C 114 Pages: 1593-1600
  • Peer Reviewed
• [Journal Article] Synthesis of polyyne molecules from Hexane irradiation by intense femtosecond laser pulses (2010)
  • Author(s): Y. Sato, T. Kodama, H. Shiromaru, J. H. Sanderson, T. Fujino, Y. Wada, T. Wakabayashi ,Y. Achiba
  • Journal Title: Carbon Volume: 48 Pages: 1673-1676
  • Peer Reviewed
• [Journal Article] Picosecond Time-resolved Fluorescence Study of Poly Vinyl Methyl Ether Aqueous Solution (2009)
  • Author(s): T. Sakamaki, *T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
  • Journal Title: Chem. Phys. Lett. Volume: 468 Pages: 171-175
  • Peer Reviewed
• [Journal Article] In-cell Viscosity Measurement Using a Fluorescence Up-conversion Microscope (2008)
  • Author(s): *T. Fujino, K. Hirota, K. Ohta, T. Tahara
  • Journal Title: Chem. Lett. Volume: 37 Pages: 1240-1241
  • Peer Reviewed
• [Journal Article] Characterization of Diffusion and Mixing Process in Microchannels (2008)
  • Author(s): Y. Takabayashi, T. Fujino, T. Korenaga
  • Journal Title: Anal. Sci. Volume: 24 Pages: 1481-1485
  • Peer Reviewed
• [Journal Article] MALDI Mass Spectrometry with Cyclodextrin-Supported Matrix (2008)
  • Author(s): S. Yamaguchi, T. Fujita, *T. Fujino, T. Korenaga
  • Journal Title: Anal. Sci Volume: 24 Pages: 1497-1500
  • Peer Reviewed
• [Journal Article] Solvation Structure of Polyacrylamide Fine Particle Surfaces Studied by Picosecond Time-resolved Fluorescence Spectroscopy (2008)
  • Author(s): T. Sakamaki, *T. Fujino, H. Hosoi, T. Tahara, T. Korenaga
  • Journal Title: Chem. Lett. Volume: 37 Pages: 980-981
  • Peer Reviewed
• [Journal Article] Femtosecond/picosecond Time-resolved Fluorescence Study of Hydrophilic Polymer Fine Particles (2007)
  • Author(s): D. Nanjo, H. Hosio, *T. Fujino, T. Tahara, and T. Korenaga
  • Journal Title: J. Phys. Chem. Volume: B, 111 Pages: 2759-2764
  • Peer Reviewed
• [Presentation] Development of Zeolite Matrix for Soft Ionization (2011)
  • Author(s): J. Suzuki, Y. Komori, T. Fujino, H. Shima, J.N. Kondo, K. Hashimoto, T. Korenaga
  • Organizer: IUPAC International Congress on Analytical Science 2011
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20110522-26
• [Presentation] Pronounced Selectivity in MALDI Mass Spectrometry with 2,4,6-trihydroxyacetophenone on zeolite surface (2010)
  • Author(s): T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
  • Organizer: The 13th Asia Pacific Confederation of Chemical Engineering Congress
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 20101005-08
• [Presentation] MALDI mass spectrometry using 2,4,6-trihydroxyacetophenone on zeolite surface enhancement of protonated species of matrix and analyte molecules (2010)
  • Author(s): T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
  • Organizer: Molecular and Ionic Clusters Conference in 2010
  • Place of Presentation: Tokamachi, Niigata
  • Year and Date: 20100905-10
• [Presentation] Pronounced Selectivity in MALDI Mass Spectrometry using 2,4,6-trihydroxy acetophenone on zeolite surface (2010)
  • Author(s): T. Fujino, Y. Komori, H. Shima, J. N. Kondo, K. Hashimoto, T. Korenaga
  • Organizer: XIII IUPAC Symposium on Photochemistry
  • Place of Presentation: Ferrara, Italy
  • Year and Date: 20100711-16
• [Presentation] Spectroscopic Characterization of Hydrophilic Fine Particles (2010)
  • Author(s): T. Fujino
  • Organizer: BIT’s 8th Annual Congress of International Drug Discovery Science and Technology
  • Place of Presentation: Beijin, China
  • Year and Date: 2010-10-24
• [Presentation] Spectroscopic Study of non-destructive ionization process for mass spectrometry (2009)
  • Author(s): T. Fujino
  • Organizer: International Symposium on “Molecular Science for Supra Functional System”
  • Place of Presentation: O-okayama, Tokyo
  • Year and Date: 2009-06-04
• [Presentation] In-cell Viscosity Measurements by Femtosecond Fluorescence Up-conversion Microscopy (2008)
  • Author(s): T. Fujino, K. Hirota, K. Ohta, T. Tahara
  • Organizer: Focus On Microscopy 2008
  • Place of Presentation: Awaji Osaka, Japan
  • Year and Date: 2008-04-15
• [Presentation] Ultrafast Solvation Dynamics of Hydrophilic Polymer Fine Particles (2007)
  • Author(s): T. Fujino, H. Hosoi, D. Nanjo, T. Tahara, and T. Korenaga
  • Organizer: XXIII International Conference on Photochemistry
  • Place of Presentation: Koln, Germany
  • Year and Date: 2007-08-02
• [Book] 生命科学のための分析化学 (2011)
  • Author(s): 伊永隆史, 藤野竜也, 他6名
  • Publisher: 化学同人
• [Book] Ultrafast Fluorescence Microscope Chapter 3 (pp. 51-70) in “Biochemical applications of nonlinear optical spectroscopy” ed. Vladislav V. Yakovlev (2009)
  • Author(s): T. Fujino, T. Tahara
  • Publisher: CRC Press
• [Patent(Industrial Property Rights)] 包接マトリックスを用いたＭＡＬＤＩ法
  • Inventor(s): 藤野竜也, 山口惣大, 伊永隆史
  • Industrial Property Rights Holder: 公立大学法人首都大学東京
  • Patent Publication Number: 特開2009-186298