Dynamic Multi-photon Spectroscopic Imaging of Intracellular Biomolecules Using a White Laser Source

2009 Fiscal Year Self-evaluation Report

• Project Area: Molecular Science for Supra Functional Systems ? Development of Advanced Methods for Exploring Elementary Process
• Project/Area Number: 19056010
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: University of Tsukuba (2011); The University of Tokyo (2007-2010)
• Principal Investigator: KANO Hideaki The University of Tokyo, 大学院・理学系研究科, 准教授 (70334240)
• Project Period (FY): 2007 – 2011
• Keywords: 分子分光

Research Abstract

本研究では,新しい光源である白色レーザーを用いることで,様々な多光子過程を顕微鏡下で実現し,生細胞などの生体試料を複眼的に可視化することを目指している.

Research Products

• [Journal Article] 非線形ラマン分光イメージング (2008)
  • Author(s): 加納英明, 濱口宏夫
  • Journal Title: ぶんせき 402 Pages: 270-277
• [Journal Article] 色レーザーを用いた非線形ラマン分光イメージング (2008)
  • Author(s): 加納英明
  • Journal Title: 分光研究 57(5) Pages: 238-248
• [Journal Article] Ultrabroadband multiplex CARS microspectroscopy and imaging using a subnanosecond supercontinuum light source in the deep near infrared (2008)
  • Author(s): Masanari Okuno, Hideaki Kano, Philippe Leproux, Vincent Couderc, *Hiro-o Hamaguchi
  • Journal Title: Opt. Lett. 33 Pages: 923-925
• [Journal Article] Ultrabroadband (>2000 cm-1) Multiplex Coherent Anti-Stokes Raman Scattering Spectroscopy Using a Sub-Nanosecond Supercontinuum Light Source (2007)
  • Author(s): Masanari Okuno, Hideaki Kano, Philippe Leproux, Vincent Couderc, Hiro-o Hamaguchi
  • Journal Title: Opt. Lett. 32 Pages: 3050-3052
• [Journal Article] Supercontinuum Dynamically Visualizes a Dividing Single Cell (2007)
  • Author(s): Hideaki Kano, Hiro-o Hamaguchi
  • Journal Title: Anal. Chem. 79 Pages: 8967-8973
• [Presentation] CARS spectroscopic imaging using a white-light laser source (2009)
  • Author(s): Hideaki Kano
  • Organizer: 5th International Conference on Advanced Vibrational Spectroscopy (ICAVS-5)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 20090712-17
• [Presentation] CARS Spectroscopic Imaging Using a Supercontinuum Laser Source (2008)
  • Author(s): Hideaki Kano, Hiro-o Hamaguchi
  • Organizer: International Conference on Raman Spectroscopy (ICORS 2008)
  • Place of Presentation: Uxbridge, UK(Invited)
  • Year and Date: 20080817-20080822
• [Presentation] COHERENT RAMAN BIOIMAGING USING A SUPERCONTINUUM LIGHT SOURCE (2007)
  • Author(s): Hideaki Kano, Hiro-o Hamaguchi
  • Organizer: International Symposium, TOPICAL PROBLEMS OF BIOPHOTONICS 2007
  • Place of Presentation: Moscow, Russia(Invited)
  • Year and Date: 20070804-20070811
• [Remarks] 加納英明:「光科学技術研究振興財団研究表彰」, 2008. 3. 6
• [Remarks] 加納英明:「日本化学会第57回進歩賞」, 2008. 3. 27
• [Remarks] 加納英明:「日本分光学会若手奨励賞」, 2009. 11. 16
• [Patent(Industrial Property Rights)] 非線形分光計測システム用の光源装置、非線形分光計測システム及び方法 (2008)
  • Inventor(s): 加納英明・濱口宏夫
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Number: 特願2008- 66832
  • Filing Date: 2008-03-14