2012 Fiscal Year Final Research Report
Cell cycle regulation of cell morphology and cell size
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OHYA Yoshikazu 東京大学, 大学院・新領域創成科学研究科, 教授 (20183767)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Dai 広島大学, 大学院・先端物質科学研究科, 教授 (30243603)
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| Project Period (FY) |
2007 – 2012
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| Keywords | 出芽酵母 / 細胞壁 / 細胞周期 / 細胞形態 / 画像解析 |
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| Research Abstract |
Cell wall integrity checkpoint is one of the cell cycle checkpoints in Saccharomyces cerevisiae. When the cell wall synthesis is perturbed, cell cycle progression stopped before nuclear division. We identified 18 genes involved in the cell wall integrity checkpoint. We showed that the checkpoint required the kinase signaling pathway that transduced signal from the cell wall to the nucleus. We also showed that phosphorylation of the transcription factor is also important for regulation of G2/M cyclin, a key regulatory factor of the checkpoint.
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