Mechanisms underlying stem cell asymmetric divisions that bifurcate proliferation and differentiation into daughters

2009 Fiscal Year Self-evaluation Report

• Project Area: Cell Proliferation Control
• Project/Area Number: 19057009
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: MATSUZAKI Fumio The Institute of Physical and Chemical Research, 非対称細胞分裂研究グループ, グループディレクター (10173824)
• Project Period (FY): 2007 – 2011
• Keywords: 分化 / 増殖 / 非対称分裂 / 神経幹細胞

Research Abstract

幹細胞は、しばしば、非対称細胞分裂によって、幹細胞自身を自己複製するとともに分化細胞を生じる.自律的な非対称分裂を行うショウジョウバエ神経幹細胞、および、細胞間相互作用に依存した非対称分裂を行うマウス神経幹細胞をモデル系として、未分化能(細胞増殖能)や分化能を娘細胞に振り分けるメカニズムに取り組み、自律的および非自律的な非対称分裂に共通するメカニズムと特異的なしくみを明らかにする。

Research Products

• [Journal Article] Structural basis for self-renewal of neural progenitors in cortical neurogenesis. (2009)
  • Author(s): S hioi G, Konno D, Shitamukai A, Matsuzaki F.
  • Journal Title: Cereb Cortex. 19Suppl1 Pages: i55-61
  • Peer Reviewed
• [Journal Article] Protein phosphatase 2A negatively regulates aPKC signaling by modulating phosphorylation of Par-6 in Drosophila neuroblast asymmetric divisions. (2009)
  • Author(s): O gawa H, Ohta N, Moon W, Matsuzaki F.
  • Journal Title: J Cell Sci. 122(Pt18) Pages: 3242-9
  • Peer Reviewed
• [Journal Article] The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. (2008)
  • Author(s): Y amamoto Y, Izumi Y, Matsuzaki F.
  • Journal Title: Biochem Biophys Res Commun. 366(1) Pages: 212-8
• [Journal Article] Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis. (2008)
  • Author(s): K onno D, Shioi G, Shitamukai A, Mori A, Kiyonari H, Miyata T, Matsuzaki F.
  • Journal Title: Nat Cell Biol. 10(1) Pages: 93-101
  • Peer Reviewed
• [Journal Article] Paths, elongation, and projections of ascending chick embryonic spinal commissural neurons after crossing the floor plate. (2008)
  • Author(s): Arakawa T, Iwashita M, Matsuzaki F, Suzuki T, Yamamoto T.
  • Journal Title: Brain Res. 1223 Pages: 25-33
  • Peer Reviewed
• [Journal Article] (2008)
  • Author(s): K awaguchi A, Ikawa T, Kasukawa T, Ueda HR, Kurimoto K, Saitou M, Matsuzaki F.
  • Journal Title: Development. 135(18) Pages: 3113-24
  • Peer Reviewed
• [Presentation] Self-renewal and differentiation of neural stem cells International Symposium. (2010)
  • Author(s): Matsuzaki F.
  • Organizer: Cell Cycle and Development
  • Place of Presentation: 京都府京都市
  • Year and Date: 2010-03-17
• [Presentation] Dynamic homeostasis of neural stem cells in the developing brain. (2010)
  • Author(s): Matsuzaki F.
  • Organizer: International Symposium:8th TLL Symposium Neurodevelopment, Behaviour and Disease
  • Place of Presentation: SINGAPORE
  • Year and Date: 2010-02-02
• [Presentation] Mechanisms controlling neural cell fate specification in mouse hippocampus. (2009)
  • Author(s): Matsuzaki F.
  • Organizer: Construction and Reconstruction of the Brain
  • Place of Presentation: 兵庫県淡路市
  • Year and Date: 2009-10-08
• [Presentation] Self-renewal and Differentiation of mammalian neural stem cells. (2009)
  • Author(s): Matsuzaki F.
  • Organizer: Bilateral workshop on developmental biology
  • Place of Presentation: Beijing, CHINA
  • Year and Date: 2009-05-08
• [Presentation] Self-renewal and Differentiation of Mammalian Neural Stem Cells. (2009)
  • Author(s): Matsuzaki F.
  • Organizer: CDB Symposium 2009 Shape and Polarity
  • Place of Presentation: CDB RIKEN兵庫県神戸市
  • Year and Date: 2009-03-23
• [Presentation] Self Renewal and Differentiation of Mammalian Neural Stem Cells. (2009)
  • Author(s): Matsuzaki F.
  • Organizer: International Symposium"Cell Cycle and Cell Architecture"
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2009-02-27
• [Presentation] Self renewal and differentiation of mammalian neural progenitor cells. (2008)
  • Author(s): Matsuzaki F.
  • Organizer: San Francisco-Japan Joint Meeting on Vertebrate Orfanogenesis
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2008-11-25
• [Presentation] Self renewal and differentiation of mammalian neural progenitor cells. (2008)
  • Author(s): Matsuzaki F.
  • Organizer: UTMDACC-CDB Joint Symposium on: Vertebrate Development and Organogenesis
  • Place of Presentation: Houston, USA
  • Year and Date: 2008-11-20
• [Presentation] Self renewal of neural progenitors during mammalian brain development (2008)
  • Author(s): Matsuzaki F.
  • Organizer: 第31回日本神経科学大会
  • Place of Presentation: 東京都
  • Year and Date: 2008-07-11
• [Presentation] Enhancer suppressor screen for Drosophila aPKC mutants. (2008)
  • Author(s): Matsuzaki F.
  • Organizer: The16th EMBO Workshop on MOLECULAR AND DEVELOPMENTAL BIOLOGY OF DROSOPHILA
  • Place of Presentation: Crete, GREECE
  • Year and Date: 2008-06-24
• [Presentation] Roles of spindle orientation in self-renewal and differentiation of neural (2008)
  • Author(s): Matsuzaki F.
  • Organizer: progenitors CORTICAL DEVELOPMENT
  • Place of Presentation: Crete, GREECE
  • Year and Date: 2008-05-22
• [Book] 細胞工学 (2009)
  • Author(s): 野大治郎、松崎文雄
  • Total Pages: 39-44
  • Publisher: 秀潤社
• [Book] シリーズ脳科学第4巻「脳の発生と発達」 (2008)
  • Author(s): 野大治郎、松崎文雄
  • Total Pages: 87-103
  • Publisher: 東京大学出版会