2011 Fiscal Year Final Research Report
Study on the mechanism underlying segregation of proliferative and differentiative activities into daughter cells during stem cell asymmetric divisions
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057009
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MATSUZAKI Fumio 独立行政法人理化学研究所, 非対称細胞分裂研究グループ, グループディレクター (10173824)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 非対称分裂 / 幹細胞 / 細胞極性 / ショウジョウバエ / マウス |
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| Research Abstract |
The mode of asymmetric division of neural stem cells in Drosophila and mouse was investigated. In Drosophila neural stem cell, cell polarity and division axis is parallel to each other such that cell fate determinants are segregated into one daughter cell to ensure division asymmetry. In contrast, we found that mouse neural stem cells undergo divisions that makes the mitotic axis perpendicular to the long epithelial axis so that one daughter inherits the entire epithelial structure, which is a prerequisite for self-renewability.
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[Journal Article] Abundant Occurrence of Basal Radial Glia in the Subventricular Zone of Embryonic Neocortex of a Lissencephalic Primate, the Common Marmoset Callithrix jacchus2011
Author(s)
Kelava I, Reillo I, Murayama AY, Kalinka AT, Stenzel D, Tomancak P, Matsuzaki F, Lebrand C, Sasaki E, Schwamborn JC, Okano H, Huttner WB, Borrell V.
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Journal Title
Cereb Cortex.
Volume: (Epub ahead of print)
Peer Reviewed
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[Journal Article] An Ana2/Ctp/Mud Complex Regulates Spindle Orientation in Drosophila Neuroblasts2011
Author(s)
Wang C, Li S, Januschke J, Rossi F, Izumi Y, Garcia-Alvarez G, Gwee SS, Soon SB, Sidhu HK, Yu F, Matsuzaki F, Gonzalez C, and Wang H.
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Journal Title
Dev Cell
Volume: 21
Pages: 520-533
Peer Reviewed
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