2011 Fiscal Year Final Research Report
Mechanisms of cell cycle arrest and its interaction with cell differentiation during development
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057011
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tottori University (2008-2011)
Mitsubishi Kagaku Institute of Life Sciences (2007) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Keiichi 九州大学, 生体防御医学研究所, 教授 (80291508)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 細胞周期、 / 増殖停止 / 細胞分化 / 発生 / 再生 / マウス / イモリ / 分子遺伝学 |
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| Research Abstract |
We have analyzed how cell cycle arrests and how cell proliferation interacts with cell differentiation during development. We showed that silencing of cycin D1 expression is required for maintenance of the cardiomyocyte cell cycle arrest, and that cycin D1 represses cardiomyocyte differentiation. These results are important for understanding tissue morphogenesis, homeostasis, and oncogenesis.
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Research Products
(28 results)
