2011 Fiscal Year Final Research Report
Organelle targeting and integration system for membrane proteins
| Project Area | Protein community: organization and maintenance of protein functions |
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| Project/Area Number |
19058013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | University of Hyogo |
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Principal Investigator |
SAKAGUCHI Masao 兵庫県立大学, 大学院・生命理学研究科, 教授 (30205736)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 膜タンパク質 / シグナル配列 / トポロジー / 生体膜 / オルガネラ |
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| Research Abstract |
In this project, we found the follows. The signal sequence, which triggers translocation of polypeptide chain, provides the motive force for polypeptide chain translocation. Positive charges of polypeptide chain cause stop-translocation in the membrane. A certain signal sequences suppress the targeting of hydrophobic segment to endoplasmic reticulum and mediate correct sorting to the cell organelle other than endoplasmic reticulum.
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[Journal Article] Multiple organelle-targeting signals in the N-terminal portion of peroxisomal membrane protein PMP702010
Author(s)
Iwashita, S., Tsuchida, M., Tsukuda, M., Yamashita, Y., Emi, Y., Kida, Y. Komori, M., Kashiwayama, Y., Imanaka, T. and Sakaguchi, M.
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Journal Title
J. Biochem.
Volume: 147(4)
Pages: 581-590
Peer Reviewed
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[Journal Article] 70-kDa peroxisomal membrane protein related protein (P70R/ABCD4) localizes to endoplasmic reticulum not peroxisomes, and NH2-terminal hydrophobic property determines the subcellular localization of ABC subfamily D proteins2009
Author(s)
Kashiwayama, Y., Seki, M., Yasui, A., Murasaki, Y., Morita, M., Yamashita, Y., Sakaguchi, M., Tanaka, Y., Imanaka, T.
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Journal Title
Exp. Cell Res.
Volume: 315
Pages: 190-205
Peer Reviewed
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[Journal Article] Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+-channel voltage-sensor domain2007
Author(s)
Zhang, L., Sato, Y., Hessa, T., von Heijne, G., Lee, J.-K., Kodama, I., Sakaguchi, M., and Uozumi. N.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 104
Pages: 8263-8268
Peer Reviewed
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