Distinct presentation and control of self and non-self

2011 Fiscal Year Final Research Report

• Project Area: Immunological Self Recognition and its Disorders
• Project/Area Number: 19059002
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tokyo Medical and Dental University (2009-2011); Akita University (2007-2008)
• Principal Investigator: OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
• Project Period (FY): 2007 – 2011
• Keywords: Tip-DCs / cDCs / pDCs / IgA / Mo-DCs / DC progenitor

Research Abstract

We found that, in the gut-associated lymphoid tissue (GALT), naturally occurring TNF/iNOS-producing DCs (Tip-DCs) regulate both T cell-dependent and -independent IgA induction, and pDCs play a prominent role in T cell-independent IgA induction. In the peripheral lymphoid tissues under severe infection, monocyte-derived DCs (Mo-DCs) perform hemophagocytosis to fine-tune excessive immune responses. Furthermore, in the BM, we identified a clonogenic progenitor with prominent pDC developmental potential.

Research Products

• [Journal Article] pDCによる新たなIgA産生誘導メカニズム. (2012)
  • Author(s): 樗木俊聡,手塚裕之
  • Journal Title: 医学のあゆみ Volume: 240 Pages: 182-183
• [Journal Article] A synthetic double-stranded RNA, poly I:C, induces a rapid apoptosis of human CD34^+ cells. (2011)
  • Author(s): Liu J, Guo Y-M, Hirokawa M, Iwamoto K, Ubukawa K, Michishita Y, Fujishima N, Tagawa H, Takahashi N, Xiao W, Yamashita J, Ohteki T, Sawada K.
  • Journal Title: Exp Hematol Volume: 40 Pages: 330-341
  • Peer Reviewed
• [Journal Article] pDCによる新たなIgA生産誘導の仕組み. (2011)
  • Author(s): 樗木俊聡
  • Journal Title: 感染・炎症・免疫 Volume: 41 Pages: 83-84
• [Journal Article] 形質細胞様樹状細胞によるT細胞非依存性IgA生産誘導機構. (2011)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 臨床免疫アレルギー科 Volume: 55 Pages: 687-692
• [Journal Article] 腸管粘膜における樹状細胞の役割 (2011)
  • Author(s): 樗木俊聡
  • Journal Title: 日本耳鼻咽喉科学会会報 Volume: 114 Pages: 107-113
• [Journal Article] T細胞非依存性IgA産生誘導における形質細胞様樹状細胞の質的優位性. (2011)
  • Author(s): 樗木俊聡, 手塚裕之
  • Journal Title: 細胞工学 Volume: 30 Pages: 376-380
• [Journal Article] Prominent role of plasmacytoid dendritic cells in mucosal T cell-independent IgA induction. (2011)
  • Author(s): Tezuka H, Abe Y, Asano J, Sato T, Liu J, Iwata M, Ohteki T.
  • Journal Title: Immunity Volume: 34 Pages: 247-257
  • Peer Reviewed
• [Journal Article] A gas governing mucosal immunity. (2011)
  • Author(s): Tezuka H, Ohteki T.
  • Journal Title: Vaccine Volume: 28(Review) Pages: 8039-8040
• [Journal Article] Regulation of intestinal homeostasis by dendritic cells. (2010)
  • Author(s): Tezuka H, Ohteki T.
  • Journal Title: Immunol Rev Volume: 234(Review) Pages: 247-258
• [Journal Article] TNF/iNOS産生DCとIgA分泌 (2010)
  • Author(s): 樗木俊聡, 手塚裕之
  • Journal Title: 医学のあゆみ Volume: 234 Pages: 453-457
• [Journal Article] Role of SIRP in regulation of mucosal immunity in the intestine. (2010)
  • Author(s): Kanazawa Y, Saito Y, Supriatna Y, Tezuka H, Kotani T, Murata Y, Okazawa H, Ohnishi H, Kinouchi Y, Nojima Y, Ohteki T, Shimosegawa T, Matozaki T.
  • Journal Title: Genes Cells Volume: 15 Pages: 1189-1200
  • Peer Reviewed
• [Journal Article] CpG-ODN 2006 and human parvovirus B19 genome consensus sequences selectively inhibit growth and development of erythroid progenitor cells. (2010)
  • Author(s): Guo Y-M, Ishii K, Hirokawa M, Tagawa H, Ohyagi H, Michishita Y, Ubukawa K, Yamashita J, Ohteki T, Onai N, Kawakami K, Xiao W, Sawada K.
  • Journal Title: Blood Volume: 115 Pages: 4569-4579
  • Peer Reviewed
• [Journal Article] Nod-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. (2010)
  • Author(s): Asano J, Tada H, Onai N, Sato T, Horie Y, Fujimoto Y, Fukase K, Suzuki A, Mak TW, Ohteki T.
  • Journal Title: J Immunol Volume: 184 Pages: 736-745
  • Peer Reviewed
• [Journal Article] MHC-matched corneal allograft rejection in an IFN-γ/IL-17-independent manner in C57BL/6 mice. (2009)
  • Author(s): Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H, Kinoshita S.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Pages: 2139-2146
  • Peer Reviewed
• [Journal Article] Interferon regulatory factor-2 protects quiescent haematopoietic stem cells from type-I interferon-dependent replicative exhaustion. (2009)
  • Author(s): Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T.
  • Journal Title: Nat Med Volume: 15 Pages: 696-700
  • Peer Reviewed
• [Journal Article] IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4^+ memory T cells in Chronic colitis. (2009)
  • Author(s): Tomita T, Kanai T, Totsuka T, Nemoto Y, Okamoto R, Tsuchiya K, Sakamoto N, Ohteki T, Hibi T, Watanabe M.
  • Journal Title: Eur J Immunol Volume: 39 Pages: 2737-2747
  • Peer Reviewed
• [Journal Article] IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease. (2008)
  • Author(s): Miyagawa F, Tagaya Y, Kim BS, Patel HJ, Ishida K, Ohteki T, Waldmann TA, Katz SI.
  • Journal Title: J Immunol Volume: 181 Pages: 1109-1119
  • Peer Reviewed
• [Journal Article] Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. (2008)
  • Author(s): Kuroda S, Nishio M, Sasaki T, Horie Y, Kawahara K, Sasaki M, Natsui M, Matozaki T, Tezuka H, Ohteki T, Forster I, Mak TW, Nakano T, Suzuki A.
  • Journal Title: Eur J Immunol Volume: 38 Pages: 1331-1340
  • Peer Reviewed
• [Journal Article] Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4^+ self-reactive T cells. (2008)
  • Author(s): Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L.
  • Journal Title: J Immunol Volume: 180 Pages: 4679-4686
  • Peer Reviewed
• [Journal Article] 樹状細胞によるTh分化制御． (2008)
  • Author(s): 小内伸幸, 樗木俊聡
  • Journal Title: 分子細胞治療 Volume: 7 Pages: 162-170
• [Journal Article] 腸管における樹状細胞のトラフィッキングとIgA生産誘導機構． (2008)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 臨床免疫・アレルギー科 Volume: 49 Pages: 10-15
• [Journal Article] IgAクラススイッチを誘導するパイエル板樹状細胞． (2008)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 臨床免疫・アレルギー科 Volume: 50 Pages: 216-221
• [Journal Article] 腸管粘膜樹状細胞によるIgAクラススイッチ制御腸内常在菌の役割． (2008)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 医学のあゆみ Volume: 227 Pages: 326-331
• [Journal Article] 腸管でのIgA生産を司るTNF/iNOS生産性樹状細胞とその作用機構． (2008)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 生体の科学 Volume: 59 Pages: 268-274
• [Journal Article] 消化管粘膜での免疫応答における樹状細胞の役割 小腸粘膜樹状細胞によるクラススイッチ制御． (2008)
  • Author(s): 手塚裕之, 安部由紀子, 樗木俊聡
  • Journal Title: 実験医学 Volume: 26 Pages: 3236-3242
• [Journal Article] 樹状細胞によるIgA生産誘導機構の新知見． (2008)
  • Author(s): 樗木俊聡, 安部由紀子, 手塚裕之
  • Journal Title: 炎症と免疫 Volume: 16 Pages: 209-214
• [Journal Article] 粘膜樹状細胞によるIgAクラススイッチ誘導機構． (2008)
  • Author(s): 安部由紀子, 手塚裕之, 樗木俊聡
  • Journal Title: 感染・炎症・免疫 Volume: 38 Pages: 271-274
• [Journal Article] Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and dendritic cell progenitors in mouse bone marrow. (2007)
  • Author(s): Onai, N, Obata-Onai, A Schmid MA, Ohteki T, Jarrossay D, Manz MG.
  • Journal Title: Nat Immunol Volume: 8 Pages: 1207-1216
  • Peer Reviewed
• [Journal Article] Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. (2007)
  • Author(s): Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa, H, Matsushita M, Shiohara T, Akira S, Ohteki T.
  • Journal Title: Nature Volume: 448 Pages: 929-933
  • Peer Reviewed
• [Journal Article] The Pten/PI3K pathway governs the homeostasis of Vα14 iNKT cells. (2007)
  • Author(s): Kishimoto H, Ohteki T, Yajima N, Kawahara K, Natsui M, Kawarasaki S,Hamada K, Horie Y, Kubo Y, Arase S, Taniguchi M, Vanhaesebroeck B, Mak TW, Nakano N, Koyasu S, Sasaki T, Suzuki A.
  • Journal Title: Blood Volume: 109 Pages: 3316-3324
  • Peer Reviewed
• [Journal Article] The dynamics of dendritic cell-mediated innate immune regulation. (2007)
  • Author(s): Ohteki T.
  • Journal Title: Allergy International Volume: 56(Review) Pages: 209-214
• [Presentation] 卓越したpDC分化能をもつ新規DC前駆細胞の同定 (2012)
  • Author(s): 樗木俊聡
  • Organizer: 第36回皮膚科免疫セミナー
  • Place of Presentation: 東京
  • Year and Date: 2012-03-03
• [Presentation] Role for plasmacytoid dendritic cells in gut IgA induction. (2012)
  • Author(s): 樗木俊聡
  • Organizer: 第4回免疫特定領域国際シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2012-01-28
• [Presentation] Role for plasmacytoid dendritic cells in gut IgA induction. (2011)
  • Author(s): Ohteki T.
  • Organizer: CFCD 3rd International pDC Workshop
  • Place of Presentation: Paris
  • Year and Date: 2011-12-08
• [Presentation] Prominent role for pDCs in mucosal IgA induction. (2011)
  • Author(s): Ohteki T.
  • Organizer: The 6th Chiba University Global COE Symposium
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-30
• [Presentation] 樹状細胞による腸管免疫調節機構新. (2011)
  • Author(s): 樗木俊聡
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-10
• [Presentation] 樹状細胞による新しい免疫寛容誘導機構. (2011)
  • Author(s): 樗木俊聡
  • Organizer: 日本免疫学会第１３回免疫サマースクール 2011 in ZAO
  • Place of Presentation: 蔵王
  • Year and Date: 2011-08-02
• [Presentation] 自己と非自己の識別掲示と制御. (2011)
  • Author(s): 樗木俊聡
  • Organizer: 特定領域研究「免疫自己系」平成23年度第１回班会議
  • Place of Presentation: 京都
  • Year and Date: 2011-07-19
• [Presentation] 腸管粘膜におけるIgA生産機構 (2011)
  • Author(s): 樗木俊聡
  • Organizer: 東京医科大学大学院セミナー
  • Place of Presentation: 東京
  • Year and Date: 2011-07-14
• [Presentation] Dendritic cells hemophagocytose to fine-tune immune responses. (2011)
  • Author(s): Ohteki T, Ohyagi H, Sawada K and Onai N.
  • Organizer: The 6th International Symposium of Institute Network. Tokyo Medical and Dental University
  • Place of Presentation: 東京
  • Year and Date: 2011-06-09
• [Presentation] 粘膜免疫と感染症 (2011)
  • Author(s): 樗木俊聡
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-28
• [Presentation] 樹状細胞による新規免疫寛容誘導機構 (2011)
  • Author(s): 樗木俊聡
  • Organizer: 第9回北東北血液研究会
  • Place of Presentation: 秋田
  • Year and Date: 2011-05-14
• [Presentation] 腸管粘膜免疫系に関する最近の知見. (2009)
  • Author(s): 樗木俊聡
  • Organizer: 第39回日本免疫学会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] 粘膜関連リンパ組織におけるIgA生産誘導機構 (2009)
  • Author(s): 樗木俊聡
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-30
• [Presentation] IgA産生と粘膜免疫応答 (2009)
  • Author(s): 樗木俊聡
  • Organizer: 第13回日本ワクチン学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2009-09-26
• [Presentation] 樹状細胞によるIgA生産誘導のメカニズム. (2009)
  • Author(s): 樗木俊聡
  • Organizer: 第46回日本消化器免疫学会総会
  • Place of Presentation: 松山
  • Year and Date: 2009-07-23
• [Presentation] 樹状細胞によるIgA生産調節機構. (2009)
  • Author(s): 樗木俊聡
  • Organizer: 第74回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2009-06-26
• [Presentation] Regulation of mucosal IgA production by dendritic cells. (2009)
  • Author(s): Ohteki T.
  • Organizer: The 2nd International Symposium of WPI-IFReC “ Dynamics of Immune Responses ”
  • Place of Presentation: Osaka
  • Year and Date: 2009-02-13
• [Presentation] 腸管粘膜組織におけるIgA生産調節機構． (2008)
  • Author(s): 樗木俊聡, 手塚裕之, 安部由紀子
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会シンポジウム「血球細胞の分化系譜」
  • Place of Presentation: 神戸
  • Year and Date: 20081209-14
• [Presentation] Regulation of mucosal IgA production by dendritic cells. (2008)
  • Author(s): Ohteki T, Abe Y, Tezuka H.
  • Organizer: 第38日本免疫学会学術集会 Symposium 5 Dendritic cell
  • Place of Presentation: 京都
  • Year and Date: 20081201-03
• [Presentation] Regulation of mucosal IgA production by dendritec cell. (2008)
  • Author(s): Ohteki T.
  • Organizer: The 10th International Symposium on Dendritic Cells
  • Place of Presentation: Kobe
  • Year and Date: 20081001-05
• [Presentation] 粘膜免疫系を支配するガス． (2008)
  • Author(s): 樗木俊聡
  • Organizer: 第32回阿蘇シンポジウム
  • Place of Presentation: 阿蘇
  • Year and Date: 20080801-02
• [Presentation] Mechanisms of IgA production in the mucosa-associated lymphoid tissue. (2008)
  • Author(s): 樗木俊聡
  • Organizer: 第3回JSI-RCAI 免疫ワークショップ「粘膜免疫機構の制御と破綻 粘膜免疫における基礎と臨床の対話」
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-14
• [Presentation] Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells. (2007)
  • Author(s): Ohteki T.
  • Organizer: The Korean Association of Immunobiologies 55th Fall Conference
  • Place of Presentation: Korea
  • Year and Date: 20071100
• [Book] 共生の成立・維持における宿主機能. 腸内生態系を調整する消化管防御システム. （財）日本ビフィズス菌センター(編) 腸内共生系のバイオサイエンス. (2011)
  • Author(s): 手塚裕之, 樗木俊聡
  • Total Pages: 173-182
  • Publisher: 丸善出版
• [Book] 樗木俊聡 粘膜系樹状細胞（誘導組織）. 清野宏(編) 臨床粘膜免疫学 (2010)
  • Author(s): 手塚裕之, 安部由紀子
  • Total Pages: 266-274
  • Publisher: （株）シナジー
• [Book] 樹状細胞による免疫調節ダイナミズム. 谷口維紹, 山本一彦（編） 免疫応答と免疫病態の統合的分子理解. (2007)
  • Author(s): 樗木俊聡
  • Total Pages: 125-134
  • Publisher: 南山堂
• [Remarks] (1)受賞 (1) 樗木俊聡, 樗木俊聡 第10回日本免疫学会賞受賞樹状細胞による免疫調節ダイナミズム研究．2007年11月21日
• [Remarks] (2)報道関連情報 (1) Tezuka H et al., Immunity 34, 247-257 (2011) に関する記事が2月18日付の日刊工業新聞、日経産業新聞朝刊に掲載された。2011年2月18日
• [Remarks]
  • URL: http://www.tmd.ac.jp/mri/bre/index.html