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2012 Fiscal Year Final Research Report

Development of vascular bundles as a center of the signaling transport

Planned Research

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Project AreaPlant regulatory systems that control developmental interactions between meristems and lateral organs
Project/Area Number 19060009
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

FUKUDA Hiroo  東京大学, 大学院・理学系研究科, 教授 (10165293)

Co-Investigator(Renkei-kenkyūsha) ITO Kyoko  東京大学, 大学院・理学系研究科, 助教 (90451830)
Project Period (FY) 2007 – 2012
Keywords成長生理 / 植物 / 発生・分化
Research Abstract

We have identified various factors involved in vascular tissue formation. In this study, we attempted to understand the function of these factors and their interrelationship at a molecular level, in view of following three aspects: (1) Regulation of vascular meristem formation by intercellular CLE peptides, (2) Regulation of vascular tissue formation by transcription factors, (3) Regulation of vascular pattern formation by spatial control of subcellular components. As a result, (1) we found intercellular and intracellular signaling pathways of CLE peptides regulating vascular meristem formation. In addition, we also indicated that TDIF functions in not only vascular but also axillary meristem formation. (2) Machinery of transcriptional regulation by VND6 via the TERE sequence was uncovered. Moreover, it was shown that bHLH transcription factors act at the initiation of vascular differentiation probably by inducing auxin transport. (3) We identified VAN3-ARF-GAP and MIDD1 as crucial factors governing cell polarity. In conclusion, we succeeded in demonstrating that vascular stem cell fates are determined by a specific transcription factor(s) regulated by a CLE peptide-dependent intracellular signaling pathway composed of a receptor kinase and a cellular kinase.

  • Research Products

    (38 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (9 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Auxin-associated initiation of vascular cell differentiation by LONESOME HIGHWAY2013

    • Author(s)
      Ohashi-Ito, K., Obuchi, M., Kojima, M., Sakakibara, H., Fukuda, H
    • Journal Title

      Development

      Volume: 140 Pages: 765-769

    • DOI

      DOI:10.1242/dev.087924

    • Peer Reviewed
  • [Journal Article] An atypical bHLH transcription factor regulates early xylem development downstream of auxin2013

    • Author(s)
      Ohashi-Ito, K., Matsukawa, M., Fukuda, H
    • Journal Title

      Plant Cell Physiol

      Volume: 54 Pages: 398-405

    • DOI

      DOI:10.1093/pcp/pct013

    • Peer Reviewed
  • [Journal Article] The proteasome is responsible for caspase-3-like activity during xylem development2012

    • Author(s)
      Han, J. J., Lin, W., Oda, Y., Cui, K. M., Fukuda, H., He, X.Q
    • Journal Title

      Plant J

      Volume: 72 Pages: 129-41

    • DOI

      DOI: 10.1111/j.1365-313X.2012.05070.x

    • Peer Reviewed
  • [Journal Article] Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking2012

    • Author(s)
      Oda, Y., Fukuda, H
    • Journal Title

      Science

      Volume: 337 Pages: 1333-1336

    • DOI

      DOI:10.1126/science.1222597

    • Peer Reviewed
  • [Journal Article] Secondary cell wall patterning during xylem differentiation2012

    • Author(s)
      Oda, Y., and Fukuda, H
    • Journal Title

      Curr. Opin. Plant Biol

      Volume: 15 Pages: 38-44

    • DOI

      DOI:10.1016/j.pbi.2011.10.005

    • Peer Reviewed
  • [Journal Article] Establishment and maintenance of vascular cell communities through local signaling2011

    • Author(s)
      Hirakawa Y., Kondo, Y., Fukuda, H
    • Journal Title

      Curr. Opin. Plant Biol

      Volume: 14 Pages: 17-23

    • DOI

      DOI:10.1016/j.pbi.2010.09.011

    • Peer Reviewed
  • [Journal Article] Dynamics of Arabidopsis SUN proteins during mitosis and involvement in nuclear shaping2011

    • Author(s)
      Oda, Y., Fukuda, H
    • Journal Title

      Plant J

      Volume: 66 Pages: 629-641

    • DOI

      DOI:10.1111/j.1365-313X.2011.04523.x

    • Peer Reviewed
  • [Journal Article] ANGUSTIFOLIA3 plays roles in adaxial/abaxial patterning and growth in leaf morphogenesis2011

    • Author(s)
      Horiguchi, G., Nakayama, H., Ishikawa N., Kubo, M., Demura, T., Fukuda, H., Tsukaya, H
    • Journal Title

      Plant Cell Physiol

      Volume: 52 Pages: 112-124

    • DOI

      DOI:10.1093/pcp/pcq178

    • Peer Reviewed
  • [Journal Article] CLE peptides can negatively regulate protoxylem vessel formation via cytokinin signaling2011

    • Author(s)
      Kondo, Y., Hirakawa, Y., Kieber, J., Fukuda, H
    • Journal Title

      Plant Cell Physiol

      Volume: 52 Pages: 37-48

    • DOI

      DOI:10.1093/pcp/pcq129

    • Peer Reviewed
  • [Journal Article] Mitogen-Activated Protein Kinase regulated by the CLAVATA receptors contributes to the shoot apical meristem homeostasis2011

    • Author(s)
      Betsuyaku, S., Takahashi, F., Kinoshita, A., Miwa, H., Shinozaki, K., Fukuda, H., Sawa, S
    • Journal Title

      Plant Cell Physiol

      Volume: 52 Pages: 14-29

    • DOI

      DOI: 10.1093/pcp/pcq157

    • Peer Reviewed
  • [Journal Article] Wood cell-wall structure requires local 2D-microtubule disassembly by a novel plasma membrane-anchored microtubuleassociated protein2010

    • Author(s)
      Oda, Y., Iida, Y., Kondo, Y., Fukuda, H
    • Journal Title

      Curr. Biol

      Volume: 20 Pages: 1197-1202

    • DOI

      DOI:10.1016/j.cub.2010.05.038

    • Peer Reviewed
  • [Journal Article] Transcriptional regulation of vascular cell fates2010

    • Author(s)
      Ohashi-Ito, K., Fukuda, H
    • Journal Title

      Curr. Opin. Plant Biol

      Volume: 13 Pages: 670-676

    • URL

      http://dx.doi.org/10.1016/j.pbi.2010.08.011

    • Peer Reviewed
  • [Journal Article] COE1, an LRR-RLK responsible for commissral vein pattern formation in rice2010

    • Author(s)
      Sakaguchi, J., Itoh, J.-I., Ito, Y., Nakamura, A., Fukuda, H., Sawa, S
    • Journal Title

      Plant J

      Volume: 63 Pages: 405-416

    • DOI

      DOI:10.1111/j.1365-313X.2010.04250.x

    • Peer Reviewed
  • [Journal Article] Arabidopsis VASCULAR-RELATED NAC-DOMAIN6 directly regulates genes that govern programmed cell death and secondary wall formation in a coordinated way during xylem differentiation2010

    • Author(s)
      Ohashi-Ito, K., Oda, Y., Fukuda, H
    • Journal Title

      Plant Cell

      Volume: 22 Pages: 3461-3473

    • URL

      http://dx.doi.org/10.1105/tpc.110.075036

    • Peer Reviewed
  • [Journal Article] TDIF peptide signaling regulates vascular stem cell proliferation via the wox4 homeobox gene in Arabidopsis2010

    • Author(s)
      Hirakawa Y., Kondo, Y., Fukuda, H
    • Journal Title

      Plant Cell

      Volume: 22 Pages: 2618-2629

    • URL

      http://dx.doi.org/10.1105/tpc.110.076083

    • Peer Reviewed
  • [Journal Article] ADP-ribosylation factor (ARF), guanine nucleotide exchange factor (GEF), and GAPase-acticating protein (GAP) function in endocytosis of plant cells2010

    • Author(s)
      Naramoto, S., Kleine-Vehn, J., Robert, S., Fujimoto, M., Dainobu, T., Paciorek, T., Ueda, T., Nakano, A., Van Montagu, M. C. E., Fukuda, H., Friml, J
    • Journal Title

      Proc. Natl. Acad. Sci., USA

      Volume: 107 Pages: 21890-21895

    • DOI

      DOI:10.1073/pnas.1016260107

    • Peer Reviewed
  • [Journal Article] A receptor-like kinase, KLAVIER, mediates systemic regulation of nodulation and non-symbiotic shoot development in Lotus japonicus2010

    • Author(s)
      Miyazawa, H., Oka-Kira, E., Sato, N., Takahashi, H., Wu, G.J., Sato, S., Hayashi, M., Betsuyaku, S., Nakazono, M., Tabata, S., Harada, Y., Sawa, S., Fukuda, H., Kawaguchi, M
    • Journal Title

      Development

      Volume: 137 Pages: 4317-4325

    • DOI

      DOI:10.1242/dev.058891

    • Peer Reviewed
  • [Journal Article] RPK2 is an essential receptor-like kinase that transmits the CLV3 signal in Arabidopsis2010

    • Author(s)
      Kinoshita, A., Betsuyaku, S., Osakabe, Y., Mizuno, S., Nagawa, S., Stahl, Y., Simon, R., Yamaguchi-Shinozaki, K., Fukuda, H., Sawa, S
    • Journal Title

      Development

      Volume: 137 Pages: 3911-3920

    • DOI

      DOI:10.1242/dev.048199

    • Peer Reviewed
  • [Journal Article] Involvement of phytosulfokine in the attenuation of stress response during the transdifferentiation of Zinnia mesophyll cells into tracheary elements2009

    • Author(s)
      Motose, H., Iwamoto, K., Endo, S., Demura, T., Sakagami, Y., Matsubayashi, Y., Moore, K. L., Fukuda, H
    • Journal Title

      Plant Physiol

      Volume: 150 Pages: 437-447

    • DOI

      DOI:org/10.1104/pp.109.135954

    • Peer Reviewed
  • [Journal Article] Phosphoinositide-dependent regulation of VAN3 ARF-GAP localization and activity essential for vascular tissue continuity in plants2009

    • Author(s)
      Naramoto, S., Sawa, S., Koizumi, K., Uemura, T., Ueda, T., Friml, J., Nakano, A., Fukuda, H
    • Journal Title

      Development

      Volume: 136 Pages: 1529-1538

    • DOI

      DOI:10.1242/dev.030098

    • Peer Reviewed
  • [Journal Article] Non-cell-autonomous control of vascular stem cell fates by a CLE peptide/receptor system2008

    • Author(s)
      Hirakawa Y., Shinohara, H., Kondo, Y., Inoue, A., Nakanomyo, I., Ogawa, M., Sawa, S., Ohashi-Ito, K., Matsubayashi, Y., Fukuda, H
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 105 Pages: 115208-15213

    • DOI

      DOI:10.1073/pnas.0808444105

    • Peer Reviewed
  • [Journal Article] VASCULAR-RELATED NAC-DOMAIN7 is involved in differentiation of all types of xylem vessels in Arabidopsis roots and shoots2008

    • Author(s)
      Yamaguchi, M., Kubo, M., Fukuda, H., Demura, T
    • Journal Title

      Plant J

      Volume: 55 Pages: 652-664

    • DOI

      DOI:10.1111/j.1365-313X.2008.03533.x

    • Peer Reviewed
  • [Journal Article] Cell differentiation in the longitudinal veins and formation of commissural veins in rice (Oryza sativa) and maize (Zea mays)2008

    • Author(s)
      Sakaguchi, J., Fukuda, H
    • Journal Title

      J. Plant Res

      Volume: 121 Pages: 593-602

    • DOI

      DOI:10.1007/s10265-008-0189-1

    • Peer Reviewed
  • [Journal Article] Transient transformation and RNA silencing in Zinnia tracheary element differentiating cell cultures2008

    • Author(s)
      Endo, S., Pesquet, E., Tashiro, G., Kuriyama, H., Goffner, D., Fukuda, H., Demura, T
    • Journal Title

      Plant J

      Volume: 53 Pages: 864-875

    • DOI

      DOI:10.1111/j.1365-313X.2007.03377.x

    • Peer Reviewed
  • [Presentation] Regulation of microtubule organization directing spatial patterning of wall assembly during xylem cell formation in Arabidopsis. Gordon Conference2012

    • Author(s)
      Fukuda, H. and Oda, Y
    • Organizer
      Plant & Microbial Cytoskeleton
    • Place of Presentation
      Andover, NH, USA
    • Year and Date
      20120812-17
  • [Presentation] Inter- and intra-signaling regulating vascular stem cell maintenance2012

    • Author(s)
      Fukuda, H, Tamaki, T., Hirakawa, Y., Kondo, Y
    • Organizer
      Plant Vascular Development, 2012
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      20120701-02
  • [Presentation] A mechanism determining cell wall pattern. International Symposium of Plant Science2012

    • Author(s)
      Fukuda, H. and Oda, Y
    • Organizer
      Plant Science for the future
    • Place of Presentation
      理化学研究所横浜研究所、鶴見
    • Year and Date
      2012-11-20
  • [Presentation] A novel membrane-associated protein regulating secondary wall patterns in an Arabidopsis cell culture harboring inducible VND62010

    • Author(s)
      Fukuda, H., Ohashi-Ito, K., Oda, Y
    • Organizer
      Cold Spring Harbor Asia Symposium "From Plant Biology to Crop Biotechnology"
    • Place of Presentation
      CSH Asia, Suzhou, China
    • Year and Date
      20101025-29
  • [Presentation] Cellular and transcriptome analyses of xylem formation with Arabidopsis cell culture systems harboring inducible VND6 and SND12010

    • Author(s)
      Fukuda, H., Oda, Y., Ohashi-Ito, K
    • Organizer
      Plant Vascular Biology 2010
    • Place of Presentation
      Ohio State University, Ohio, USA
    • Year and Date
      20100723-28
  • [Presentation] CLE peptides regulating vascular stem cell fates2010

    • Author(s)
      Fukuda, H., Kondo, Y., Hirakawa, Y
    • Organizer
      21st International Conference on Arabidopsis Research
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      20100606-10
  • [Presentation] Peptide signals governing vascular stem cell fates2010

    • Author(s)
      Fukuda, H. Kondo, Y., Hirakawa, Y
    • Organizer
      Keystone symposia 2010
    • Place of Presentation
      Granlibakken Resort, Tahoe City, California, USA
    • Year and Date
      20100314-19
  • [Presentation] Crosstalk between xylem and phloem production through a peptide2009

    • Author(s)
      Fukuda, H. Kondo, Y., Hirakawa, Y
    • Organizer
      Plant Vascular Biology and Agriculture 2009
    • Place of Presentation
      Chongqing, China
    • Year and Date
      2009-06-22
  • [Presentation] Cell-cell communication governing vascular tissue organization2008

    • Author(s)
      Fukuda, H
    • Organizer
      The XVI Congress of the Federation of European Societies of Plant Biology
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      2008-08-21
  • [Book] Peptide regulating vascular development. In "Plant Signaling Peptides" (eds. H. R. Irving and C. Gehring), p.59-752012

    • Author(s)
      Fukuda, H
    • Total Pages
      284
    • Publisher
      Springer
    • URL

      ISBN: 978-3-642-27602-6 (Print), 978-3-642-27603-3 (Online)

  • [Book] Plant tissue cultures. In "Methods in Molecular Biology: The Plant Cell Wall"(eds. Z. A. Popper), vol.715, p.1-202011

    • Author(s)
      Karkonen, A., Santanen, A., Iwamoto K., Fukuda, H
    • Total Pages
      310
    • Publisher
      Springer
    • URL

      DOI: 10.1007/978-1-61779-008-9_1, ISBN 9781617790072

  • [Book] Plant tracheary elements. In "Encyclopedia of Life Sciences", Wiley Online Library2010

    • Author(s)
      Fukuda, H
    • Publisher
      Wiley-Blackwell
    • URL

      DOI:10.1002/9780470015902.a0001814.pub2

  • [Book] CLE ペプチドによる維管束形成の制御、植物のシグナル伝達 - 分子と応答(柿本、高山、福田、松岡編), p.172-1772010

    • Author(s)
      平川有宇樹、近藤侑貴、福田裕穂
    • Total Pages
      238
    • Publisher
      共立出版
  • [Remarks]

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/seigyo/lab.html

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Published: 2014-08-29  

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