2012 Fiscal Year Final Research Report
Epigenetic control of meristem function
| Project Area | Plant regulatory systems that control developmental interactions between meristems and lateral organs |
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| Project/Area Number |
19060014
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
KAKUTANI Tetsuji 国立遺伝学研究所, 総合遺伝研究系, 教授 (20332174)
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| Project Period (FY) |
2007 – 2012
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| Keywords | DNA メチル化 / クロマチン |
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| Research Abstract |
DNA hypomethylation mutation ddm1 (decrease in DNA methylation) induces several types of developmental defects through heritable effects on other loci. One of them, which we named bonsai, was due to transcriptional repression of the responsible gene, which is associated with local increase in DNA methylation. Genetic analyses revealed that the methylation does not depend on RNAi machinery. We also screened mutants inducing BONSAI methylation and identified a novel factor IBM1 (increase in BONSAI methylation). Genome-wide analyses revealed that IBM1 ensures normal plant development by removing heterochromatin marks from transcribed sequences.
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[Journal Article] Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET12011
Author(s)
To TK, Kim JM, Matsui A, Kurihara Y, Morosawa T, Ishida J, Tanaka M, Endo T, Kakutani T, Toyoda T, Kimura H, Yokoyama S, Shinozaki K, Seki M
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Journal Title
PLoS Genet
Volume: 7
Pages: e1002005
Peer Reviewed
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