2012 Fiscal Year Final Research Report
Regulation of gene expression reprogramming in the oocytes and embryos.
| Project Area | The germline: its developmental cycle and epigenome network |
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| Project/Area Number |
20062002
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AOKI Fugaku 東京大学, 大学院・新領域創成科学研究科, 教授 (20175160)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 卵 / 初期胚 / リプログラミング / エピジェネティクス |
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| Research Abstract |
To elucidate the mechanism regulating the reprogramming of gene expression after fertilization, I investigated the change in the gene expression pattern after fertilization in mice. I identified 4,000 genes which are expressed in the 1-cell stage embryos and found that in this set of genes, there are many genes which were not expressed before fertilization. The analysis for the dynamics of histone variants revealed that H2A and H3 variants are dramatically replaced in the whole genome just after fertilization, which would be involved in the regulation of gene expression reprogramming.
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