2012 Fiscal Year Final Research Report
Regulation of germ line function and development by genome imprinting
| Project Area | The germline: its developmental cycle and epigenome network |
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| Project/Area Number |
20062009
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KONO Tomohiro 東京農業大学, 応用生物科学部, 教授 (80153485)
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| Co-Investigator(Renkei-kenkyūsha) |
OBATA Yayoi 東京農業大学, 応用生物科学部, 准教授 (70312907)
OGAWA Hidehiko 東京農業大学, 応用生物科学部, 准教授 (20339089)
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| Project Period (FY) |
2008 – 2012
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| Keywords | ゲノムインプリント / 二母性胚 / 遺伝子発現 / 個体発生 / 非翻訳RNA |
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| Research Abstract |
We showed novel findings that imprint gene clusters, including the non-cording RNAs, in the Igf2-H19 domain of the chromosome 7 and the Dlk1-Dio3 domain of the chromosome 12, play a decisive role for embryogenesis and placentation. In addition, we provided comprehensive and single resolution DNA methylome data of germ cells, and also we showed particular functions of maternal genome on embryogenesis in cloned embryos and trophoblastic stem cells.
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[Journal Article] Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks2012
Author(s)
Kobayashi H, Sakurai T, Imai M, Takahashi N, Fukuda A, Yayoi O, Sato S, Nakabayashi K, Hata K, Sotomaru Y, Suzuki Y, Kono T
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Journal Title
PLoS Genet
Volume: 8(1)
Pages: e1002440
DOI
Peer Reviewed
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[Journal Article] Developmental ability of trophoblast stem cells in uniparental mouse embryos2009
Author(s)
Ogawa H, Shindo N, Kumagai T, Usami Y, Shikanai M, Jonwn K, Fukuda A, Kawahara M, Sotomaru Y, Tanaka S, Arima T, Kono T
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Journal Title
Placenta
Volume: 30(5)
Pages: 448-456
DOI
Peer Reviewed
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