2012 Fiscal Year Final Research Report
Design of Soft-Interface with Biofunctional Branched Polymers
| Project Area | Molecular Soft-Interface Science |
|---|
| Project/Area Number |
20106003
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Science and Engineering
|
|---|
| Research Institution | Kyushu University (2010-2012)
Japan Advanced Institute of Science and Technology (2008-2009) |
|---|
Principal Investigator |
MIURA Yoshiko 九州大学, 工学研究院, 教授 (00335069)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
HOSHINO Yu 九州大学, 工学研究院, 助教 (40554689)
|
|---|
| Project Period (FY) |
2008 – 2012
|
| Keywords | 界面 / 樹状高分子 / 生体高分子 / 分子認識 / 自己組織化 |
|---|
| Research Abstract |
Dendrimer immobilized interfaces were prepared, and the material properties were investigate in terms of the regular and oriented molecular assemblies.
First, the glycodendrimer interfaces were prepared as sugar array, and the sugar-protein interactions were investigated. Since the glycodendrimer with higher generation displayed the dense saccharide structure, the glycodendrimer was a suitable tool to investigate the sugar-protein interaction. The multivalent dendrimer sugar arrays were also prepared with a sulfonated sugar. The glycodendrimer arrays with a sulfonated sugar showed the interaction with Alzheimer amyloid β peptide. Amyloid β formed fibril with low toxicity on the monovalent sugar interface, and formed spherical objects with high toxicity on the divalent and trivalent sugar interface.
The self-assembled monolayers (SAMs) of polyamidoamine (PAMAM) dendrimer with carboxylate terminal showed the strong wettability due to the densely packed hydrophilic group and the large surface area. In addition, the SAMs of PAMAM with higher generation showed the inert properties to protein adsorption because of molecular repulsion.
|
