2012 Fiscal Year Final Research Report
Preparation of thermoresponsive soft interfaces for modulation of biomolecules interaction
| Project Area | Molecular Soft-Interface Science |
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| Project/Area Number |
20106004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | ソフト界面 / ポリ(N-イソプロピルアクリルアミド)(PNIPAAm) / 原子移動ラジカル重合 / 温度応答性 / 生体分子 / 分離 / 固定化金属イオンアフィニティー / モノリスカラム |
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| Research Abstract |
In the present research, we prepared thermoresponsive soft interfaces on capillary luminal surface. Thermoresponsive surface property alteration was utilized to the modulated interaction of tiny amount of biomolecules. Steroids and/or proteins interaction regulated by temperature on poly(N-isopropylacrylamide) (PNIPAAm) anditsderivwasatives modified surfaces. Thus we proposed the design of thermoresponsive surfaces in microcapillary to separate and analyze the tiny amount of biomolecules.
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