Study on Soft Interfaces with Immobilized Biofunctional Molecules by Surface Forces Measurements

2010 Fiscal Year Self-evaluation Report

• Project Area: Molecular Soft-Interface Science
• Project/Area Number: 20106005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Tohoku University
• Principal Investigator: KURIHARA Kazue Tohoku University, 原子分子材料科学高等研究機構, 教授 (50252250)
• Project Period (FY): 2008 – 2012
• Keywords: 表面・界面物性 / ナノバイオ / ナノ材料 / 分子認識 / 高分子ブラシ

Research Abstract

本研究は、2つの表面間の相互作用の距離依存性を直接評価できる表面力測定を中心手段とし、分子認識など、固-液界面における分子膜の特性を明らかにし、ソフト界面の分子科学に寄与することを目的とし、さらに生体分子間の相互作用、医用材料表面の評価を可能とする方法論の開発を目指す。
具体的には、様々な生体分子の配向制御した固定化法の開発、DNAの転写制御に関与するタンパク質群の相互作用の直接測定を行い、さらに領域内の他の研究者の扱う高分子ブラシ層ならびに分子認識系の評価を行い、その特性を明らかにし、ソフト界面の分子科学の確立に資する。

Research Products

• [Journal Article] Polyelectrolyte Brushes Studied by Surface Forces Measurement (2010)
  • Author(s): K.Kurihara
  • Journal Title: Adv.Colloid Interface Sci. 158 Pages: 130-138
  • Peer Reviewed
• [Journal Article] Resonance Shear Measurement of Nanoconfined Ionic Liquids (2010)
  • Author(s): K.Ueno, M.Kasuya, M.Watanabe, M.Mizukami, K.Kurihara
  • Journal Title: Phys.Chem.Chem.Phys. 12 Pages: 4066-4071
  • Peer Reviewed
• [Journal Article] Nanorheology and Nanotribology of Two-Component Liquid Crystal (2009)
  • Author(s): H.Mizuno, T.Haraszti, M.Mizukami, K.Kurihara
  • Journal Title: SAE Int.J.Fuels Lubr. 1 Pages: 1517-1523
  • Peer Reviewed
• [Journal Article] Fourier-transform Resonance Shear Measurement for Studying Confined Liquids (2009)
  • Author(s): H.Sakuma, K.Kurihara
  • Journal Title: Rev.Sci.Instrum. 80 Pages: 013701-1-013701-4
  • Peer Reviewed
• [Journal Article] A New Physical Model for Resonance Shear Measurement of Confined Liquids between Solid Surfaces (2008)
  • Author(s): M.Mizukami, K.Kurihara
  • Journal Title: Rev.Sci.Instrum. 79 Pages: 113705-1-113705-6
  • Peer Reviewed
• [Presentation] Surface Forces Measurement for Nano-Materials Science (2011)
  • Author(s): K.Kurihara
  • Organizer: The Fifth Biennial Australian Colloid & Interface Symposium (ACIS2011)
  • Place of Presentation: Hobert, Australia(Alexander Lectureship Award)
  • Year and Date: 2011-01-31
• [Presentation] Surface Forces Measurements to Evaluate Biological Molecular Recognition (2010)
  • Author(s): K.Kurihara
  • Organizer: Pacifichem 2010
  • Place of Presentation: Honolulu.Hawaii, USA, 2010/12/18.(Invited)
  • Year and Date: 2010-12-08
• [Presentation] Surface forces measurement for materials nano-technology (2010)
  • Author(s): K.Kurihara
  • Organizer: The 9th Japan-France Workshop on Nanomaterials
  • Place of Presentation: Toulouse, France(Invited)
  • Year and Date: 2010-11-25
• [Presentation] Hydrogen-bonded Molecular Macrocluster Formation on Silica in Binary Liquids (2010)
  • Author(s): K.Kurihara
  • Organizer: 18th International Symposium on Surfactants in Solution
  • Place of Presentation: Melbourne, Australia(Pleanary)
  • Year and Date: 2010-11-17
• [Presentation] Molecular Analysis of Liquid Adsorption at the Solid/Liquid Interfaces : Surface Forces Measurement and Surface Selective Spectroscopy (2009)
  • Author(s): M.Mizukami
  • Organizer: The Biennial Australian Colloid and Interface Symposium
  • Place of Presentation: Adelaide, Australia(Keynote)
  • Year and Date: 2009-02-05
• [Book] 新しい局面を迎えた界面の分子科学(ナノレオロジー\ナノトライボロジー)(13章) (2011)
  • Author(s): 水上雅史,栗原和枝
  • Total Pages: 144-150
  • Publisher: 化学同人
• [Book] Nanohybridization of Organic-Inorganic Materials(Single Molecular Film for Recognizing Biological Molecular Interaction : DNA-Protein Interaction and Enzyme Reaction)(Chap.6) (2009)
  • Author(s): K.Kurihara
  • Total Pages: 125-136
  • Publisher: Springer
• [Book] ソフトマター 分子設計・キャラクタリゼーションから機能性材料まで(表面力測定)(3章4節) (2009)
  • Author(s): 栗原和枝
  • Total Pages: 165-179
  • Publisher: 丸善
• [Book] 超分子サイエンス&テクノロジー(超分子における分子間力)(1章2節1項) (2009)
  • Author(s): 粕谷素洋, 栗原和枝
  • Total Pages: 8-13
  • Publisher: エヌ・ティー・エス
• [Book] 現代界面コロイド化学の基礎(表面力装置(SFA))(9章1節5項) (2009)
  • Author(s): 水上雅史, 栗原和枝
  • Total Pages: 404-409
  • Publisher: 丸善
• [Remarks] ホームページ
  • URL: http://www.tagen.tohoku.ac.jp/labo/kurihara/index.html