2013 Fiscal Year Final Research Report
Nano-fabrication of Molecular Recognition Biointerfaces and Application to Cell Analysis Micro-biodevices
| Project Area | Molecular Soft-Interface Science |
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| Project/Area Number |
20106012
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKAI Madoka 東京大学, 工学(系)研究科(研究院), 教授 (40287975)
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| Project Period (FY) |
2008-04-01 – 2014-03-31
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| Keywords | 生体材料 / ナノバイオ / 分子認識 / 細胞 / 表面界面 |
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| Research Abstract |
To consider cell-materials interaction, we studied to understand the initial cell adhesion behavior on the materials surface using quartz crystal microbalance with dissipation (QCM-D). The first phase of cell-material interactions is protein adsorption and after that cells start to attach, adhere and spread on the protein adsorption layer. A total series of the protein adsorption behavior and cell adhesion behavior on different material surfaces has been evaluated clearly by QCM-D.
The adhesion strength of cell-materials interface can be also evaluated by QCM-D. QCM-D is one of the analytical tools for evaluating the adhesive strength, which is an index of the interaction between cell and materials and is characterized by real time monitoring.
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