Design of artificial and half-artificial nano structure bearing dynamic cavity

2010 Fiscal Year Self-evaluation Report

• Project Area: Emergent Chemistry of Nano-scale Molecular System
• Project/Area Number: 20111010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: The University of Tokyo
• Principal Investigator: AIDA Takuzo The University of Tokyo, 大学院・工学系研究科, 教授 (00167769)
• Project Period (FY): 2008-11-13 – 2013-03-31
• Keywords: 自己組織化 / 分子シャペロン / ナノチューブ / 散逸構造

Research Abstract

本申請研究は、当研究室で見いだされた“シャペロン改変体の1次元のチューブ状集合化"を基礎としている。
(1)チューブの形成と解離条件の最適化。
(2)チューブの応答性(ATP、光)。
(3)新規なシャペロンの設計。
(4)集合構造のゲスト取り込み能の探索。

Research Products

• [Journal Article] Shape-Directed Assembly of a "Macromolecular Barb" into Nanofibers : Stereospecific Cyclopolymerization of Isopropylidene Diallylmalonate (2010)
  • Author(s): Yasunao Miyamura, Kazushi Kinbara, Yohei Yamamoto, Valayil K.Praveen, Kenichi Kato, Masaki Takata, Atsushi Takano, Yushu Matsushita, Eunji Lee, Myongsoo Lee, Takuzo Aida
  • Journal Title: Journal of the American Chemical Society 132 Pages: 3292-3294
• [Journal Article] A Tubular Biocontainer : Metal Ion-Induced 1D Assembly of Molecularly Engineered Chaperonin (2009)
  • Author(s): Shuvendu Biswas, Kazushi Kinbara, Nobuhiro Oya, Noriyuki Ishii, Hideki Taguchi, Takuzo Aida
  • Journal Title: Journal of the American Chemical Society 131 Pages: 7556-7557
• [Presentation] Bionanotubular Machines from Molecular Chaperones : A New Paradigm for ATP-Responsive Protein Delivery (2010)
  • Author(s): Shuvendu Biswas, Kazushi Kinbara, Noriyuki Ishii, Hideki Taguchi, Takuzo Aida
  • Organizer: Trilateral Symposium on Nanobio Integration Berlin
  • Place of Presentation: Germany
  • Year and Date: 2010-10-02
• [Presentation] ポリマーの立体規則性が支配する散逸構造 (2010)
  • Author(s): 宮村泰直, 金原数, 相田卓三
  • Organizer: 第59回高分子討論会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-09-16
• [Presentation] 化学修飾した分子シャペロンの組織化による刺激応答性チューブ状バイオコンテナーの合成 (2010)
  • Author(s): ビスワス シュヴェンドゥ、金原数、石井則行、田口英樹、相田卓三
  • Organizer: 第59回高分子討論会
  • Place of Presentation: 北海道大学
  • Year and Date: 2010-09-16