Design of artificial and half-artificial nano structure bearing dynamic cavity

2013 Fiscal Year Final Research Report

• Project Area: Emergent Chemistry of Nano-scale Molecular System
• Project/Area Number: 20111010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: The University of Tokyo
• Principal Investigator: AIDA Takuzo 東京大学, 大学院工学系研究科, 教授 (00167769)
• Project Period (FY): 2008-11-13 – 2013-03-31
• Keywords: 創発化学 / シャペロニン / 自己組織化 / 刺激応答性 / 強誘電性液晶 / カラムナー液晶

Research Abstract

An unexpected material property which could not be explained simply by the sum of the properties of a part. In the field of emergent chemistry, people try to find and explore this phenomenon in molecular level in order to develop novel functional materials. Based on our recent finding of emergent one-dimensional assembly of biomacromolecules, we have developed a novel drug delivery system utilizing artificially modified protein assemblies and the first ferroelectric columnar liquid crystal.

Research Products

• [Journal Article] Photoreconfigurable Supramolecular Nanotube (2013)
  • Author(s): T.Sendai, S.Biswas, and T.Aida
  • Journal Title: J. Am. Chem. Soc. Volume: 135 Pages: 11509-11509
  • DOI: 10.1021/ja4060146
  • Peer Reviewed
• [Journal Article] Biomolecular Robotics for Chemomechanically Driven Guest Delivery Fuelled by Intracellular ATP (2013)
  • Author(s): S.Biswas, K.Kinbara, T.Niwa, H.Taguchi, N.Ishii, S.Watanabe, K.Miyata, K.Kataoka and T.Aida
  • Journal Title: Nature Chemistry Volume: 5 Pages: 613-620
  • DOI: 10.1038/NCHEM.1681
  • Peer Reviewed
• [Journal Article] High-Optical-Quality Ferroelectric Film Wet-Processed from a Ferroelectric Columnar Liquid Crystal as Observed with Nonlinear-Optical Microscopy (2013)
  • Author(s): F.Araoka, S.Masuko, A.Kogure, D.Miyajima, T.Aida and H.Takezoe
  • Journal Title: Advanced Materials Volume: 25 Pages: 4014-4017
  • DOI: 10.1002/adma.201301380
  • Peer Reviewed
• [Journal Article] Ferroelectric Columnar Liquid Crystal Featuring Confined Polar Groups Within Core-Shell Architecture (2012)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, J.Kim, K.Kato, M.Takata, and T.Aida
  • Journal Title: Science Volume: 336 Pages: 209-213
  • DOI: 10.1126/science.1217954
  • Peer Reviewed
• [Journal Article] Electric-Field-Responsive Handle for Large-Area Orientation of Discotic Liquid-Crystalline Molecules in Millimeter-Thick Films (2011)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, J.Kim, K.Kato, M.Takata, and T.Aida
  • Journal Title: Angew. Chem., Int. Ed. Volume: 50 Pages: 7865-7869
  • DOI: 10.1002/anie.201102472
  • Peer Reviewed
• [Journal Article] Columnar Liquid Crystal with a Spontaneous Polarization along the Columnar Axis (2010)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, J.Kim, K.Kato, M.Takata, and T.Aida
  • Journal Title: J. Am. Chem. Soc. Volume: 132 Pages: 8530-8531
  • DOI: 10.1021/ja101866e
  • Peer Reviewed
• [Journal Article] A Tubular Biocontainer : Metal Ion-Induced 1D Assembly of a Molecularly Engineered Chaperonin (2009)
  • Author(s): S.Biswas, K.Kinbara, N.Oya, N.Ishii, H.Taguchi, and T.Aida
  • Journal Title: J. Am. Chem. Soc. Volume: 131 Pages: 7556-7557
  • DOI: 10.1021/ja902696q
  • Peer Reviewed
• [Journal Article] Liquid Crystalline Corannulene Responsive to Electric Field (2009)
  • Author(s): D.Miyajima, K.Tashiro, F.Araoka, H.Takezoe, J.Kim, K.Kato, M.Takata, and T.Aida
  • Journal Title: J. Am. Chem. Soc. Volume: 131 Pages: 44-45
  • DOI: 10.1021/ja808396b
  • Peer Reviewed
• [Presentation] Structural Control from Molecular Up to Macroscopic Size Regimes for Developing Functional Soft Materials (2013)
  • Author(s): T.Aida
  • Organizer: 3rd International Conference on Multifunctional, Hybrid and Nanomaterials
  • Place of Presentation: Sorrento, Italy
  • Year and Date: 2013-03-07
• [Presentation] Advanced Molecular Design for New Soft Functional Materials (2013)
  • Author(s): T.Aida
  • Organizer: Sixth International Conference on Advanced Materials and Nanotechnology
  • Place of Presentation: Auckland, New Zealand
  • Year and Date: 2013-02-14
• [Presentation] Supramolecular Polymerization Mediated by Light (2012)
  • Author(s): T.Sendai, S.Biswas, and T.Aida
  • Organizer: The 9th SPSJ International Polymer Conference
  • Place of Presentation: 神戸国際会議場, 兵庫
  • Year and Date: 2012-12-12
• [Presentation] Advanced Molecular Design of Functional Materials (2012)
  • Author(s): T.Aida
  • Organizer: Polydays 2012 : Polymers and Light
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2012-10-02
• [Presentation] 強誘電性カラムナー液晶 -分子デザインと基礎物性- (2012)
  • Author(s): 宮島 大吾, 相田 卓三, 荒岡 史人, 竹添 秀男
  • Organizer: 日本液晶学会討論会
  • Place of Presentation: 千葉大学, 千葉
  • Year and Date: 2012-09-05
• [Presentation] 光制御可能な超分子重合反応の開拓 (2012)
  • Author(s): 千代 敏弘, Biswas Shuvendu, 相田 卓三
  • Organizer: 第61回高分子学会年次大会
  • Place of Presentation: パシフィコ横浜, 神奈川
  • Year and Date: 2012-05-30
• [Presentation] Advanced Molecular Design for Functional Materials (2012)
  • Author(s): T.Aida
  • Organizer: NANAX5
  • Place of Presentation: Maraga, Spain
  • Year and Date: 2012-05-07
• [Presentation] Universal Design Strategy for Alignable Liquid Crystalline Organic Semiconductors (2012)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, and T.Aida
  • Organizer: MRS Spring Meeting 2012
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-04-03
• [Presentation] 分子シャペロンの重合反応の光制御 (2012)
  • Author(s): 千代 敏弘, Biswas Shuvendu, 相田 卓三
  • Organizer: 日本化学会第92春季年会
  • Place of Presentation: 慶應義塾大学, 神奈川
  • Year and Date: 2012-03-25
• [Presentation] Advanced Functional Materials via Controlled Molecular Assembly (2012)
  • Author(s): T.Aida
  • Organizer: Controlled Self-assembly and Fictionalization Forum
  • Place of Presentation: Xiamen, China
  • Year and Date: 2012-01-14
• [Presentation] Functional Materials via Controlled Molecular Assembly (2011)
  • Author(s): T.Aida
  • Organizer: Second IAC meeting and research symposium
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2011-11-28
• [Presentation] シャペロンバイオナノチューブ(1):化学修飾した分子シャペロンの一次元組織化とDDSへの応用に向けた刺激応答性 (2011)
  • Author(s): Biswas Shuvendu, 金原 数, 石井 則行, 田口 英樹, 相田 卓三
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学, 岡山
  • Year and Date: 2011-09-29
• [Presentation] シャペロンバイオナノチューブ(2)-化学修飾した分子シャペロンをモノマーユニットとした光制御型超分子重合 (2011)
  • Author(s): 千代 敏弘, Biswas Shuvendu, 田口 英樹, 相田 卓三
  • Organizer: 第60回高分子討論会
  • Place of Presentation: 岡山大学, 岡山
  • Year and Date: 2011-09-29
• [Presentation] Tailoring Functional Soft Materials through Advanced Molecular Design (2011)
  • Author(s): T.Aida
  • Organizer: Challenges in Organic Materials & Supramolecular Chemistry (ISACS6)
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-09-03
• [Presentation] Columnar Ferroelectric Liquid Crystals with Paraelectric Pendants (2011)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, and T.Aida
  • Organizer: 13th International Conference on Ferroelectric Liquid Crystals
  • Place of Presentation: Niagara Falls, Canada
  • Year and Date: 2011-08-30
• [Presentation] Tailoring Functional Soft Materials through Advanced Molecular Design (2011)
  • Author(s): T.Aida
  • Organizer: The 17th European Symposium on Organic Chemistry
  • Place of Presentation: Crete, Greece
  • Year and Date: 2011-07-14
• [Presentation] Light-driven Nanotubular Assembly of Molecular Chaperons and Its Applications (2011)
  • Author(s): T.Sendai, et al.
  • Organizer: Gordon Research Conference Supramolecules & Assemblies, Chemistry of Properties and Organization at Multiple Scales
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-06-22
• [Presentation] A Nanotubular Molecular Machine by Designed Supramolecular Assembly of Chaperonin Protein GroEL (2011)
  • Author(s): S.Biswas, et al.
  • Organizer: Gordon Research Conference Supramolecules & Assemblies, Chemistry of Properties and Organization at Multiple Scales
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-06-20
• [Presentation] Molecular Design of Macroscopic Phenomena (2011)
  • Author(s): T.Aida
  • Organizer: Gordon Research Conference Supramolecules & Assemblies, Chemistry of Properties and Organization at Multiple Scales
  • Place of Presentation: Lucca, Italy
  • Year and Date: 2011-06-20
• [Presentation] 分子シャペロンバイオナノチューブ(1):化学修飾したGroELの一次元組織化とDDSへの応用に向けた刺激応答性 (2011)
  • Author(s): Biswas Shuvendu, 金原 数, 石井 則行, 田口 英樹, 宮田 完二郎, 片岡 一則, 相田 卓三
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学, 神奈川
  • Year and Date: 2011-03-27
• [Presentation] 分子シャペロンバイオナノチューブ(2):外部刺激によるGroEL 変異体一次元集積の制御 (2011)
  • Author(s): 千代 敏弘, Biswas Shuvendu, 田口 英樹, 相田 卓三
  • Organizer: 日本化学会第91春季年会
  • Place of Presentation: 神奈川大学, 神奈川
  • Year and Date: 2011-03-27
• [Presentation] Universal Design Strategy for Uniformly Alignable Discotic Columnar Liquid Crystal (2010)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, and T.Aida
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-17
• [Presentation] Stimuli-responsive Bionanotubes by Supramolecular Polymerization of Chemically Modified Chaperonin-based Biomolecular Machineries (2010)
  • Author(s): S.Biswas, K.Kinbara, N.Ishii, H.Taguchi, and T.Aida
  • Organizer: The 2010 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-12-17
• [Presentation] Tailoring Functional Organic Materials by Advanced Molecular Design and Programmed Assembly (2010)
  • Author(s): T.Aida
  • Organizer: 2010 Novartis Lecture in Organic Chemistry at the University of Illinois
  • Place of Presentation: Illinois, USA
  • Year and Date: 2010-10-07
• [Presentation] Bionanotubular Machines from Molecular Chaperones : A New Paradigm for ATP-Responsive Protein Delivery (2010)
  • Author(s): S.Biswas, et al.
  • Organizer: Trilateral Symposium on Nanobio Integration
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2010-10-02
• [Presentation] 化学修飾した分子シャペロンの組織化による刺激応答性チューブ状バイオコンテナーの合成 (2010)
  • Author(s): ビスワス シュヴェンドゥ, 金原 数, 石井 則行, 田口 英樹, 相田 卓三
  • Organizer: 第59回高分子討論会
  • Place of Presentation: 北海道大学, 北海道
  • Year and Date: 2010-09-15
• [Presentation] 強誘電性カラムナー液晶の開発 (2010)
  • Author(s): 宮島 大吾, 相田 卓三, 荒岡 史人, 竹添 秀男
  • Organizer: 日本液晶学会討論会
  • Place of Presentation: 九州大学, 福岡
  • Year and Date: 2010-09-07
• [Presentation] New Approach for the Alignment of the Discotic Columnar Liquid Crystals with the Combination of the Amide and Electric Field (2010)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, and T.Aida
  • Organizer: The 23^<rd> International Liqud Crystalline Conference 2010
  • Place of Presentation: Krakow, Poland
  • Year and Date: 2010-07-16
• [Presentation] Programmed Molecular Assembly for Tailored Functional Materials (2010)
  • Author(s): T.Aida
  • Organizer: 12th International Conference on Modern Materials and Technologies
  • Place of Presentation: Tuscany, Italy
  • Year and Date: 2010-06-14
• [Presentation] 電場応答性を有するディスコティックカラムナー液晶の開発 (2010)
  • Author(s): 宮島 大吾, 荒岡 史人, 竹添 秀男, 相田 卓三
  • Organizer: 日本化学会第90春季年会
  • Place of Presentation: 近畿大学, 大阪
  • Year and Date: 2010-03-27
• [Presentation] Functional Soft Materials by Programmed Self-Assembly (2009)
  • Author(s): T.Aida
  • Organizer: The Stephanie Kwolek Lecture in Materials Chemistry at Carnegie Mellon University
  • Place of Presentation: Pittsburg, USA
  • Year and Date: 2009-11-05
• [Presentation] Programmed Molecular Assembly for Tailored Functional Materials (2009)
  • Author(s): T.Aida
  • Organizer: Aquitaine Conference on Polymers
  • Place of Presentation: Arcachon, France
  • Year and Date: 2009-10-14
• [Presentation] Programmed Molecular Assembly for Tailored Functional Materials (2009)
  • Author(s): T.Aida
  • Organizer: The Second Asian Symposium on Advanced Materials
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-10-12
• [Presentation] Molecular Programming of Complex Nanostructures for Advanced Functions (2009)
  • Author(s): T.Aida
  • Organizer: First International Meeting on Organic Materials for a Better Future
  • Place of Presentation: Brindisi, Italy
  • Year and Date: 2009-09-13
• [Presentation] Synthesis of New Bowlic Liquid Crystals Responsive to Electric Field (2009)
  • Author(s): D.Miyajima, F.Araoka, H.Takezoe, and T.Aida
  • Organizer: The 12th International Conference on Ferroelectric Liquid Crystals
  • Place of Presentation: Zaragoza, Spain
  • Year and Date: 2009-09-03
• [Presentation] Molecular Design for Advanced Functions (2009)
  • Author(s): T.Aida
  • Organizer: 40th CUSO Summer School in Organic Chemistry
  • Place of Presentation: villas, Switzerland
  • Year and Date: 2009-08-27
• [Presentation] Molecular Programming for Advanced Polymeric and Supramolecular Materials (2009)
  • Author(s): T.Aida
  • Organizer: American Chemical Society Spring 2009 National Meeting
  • Place of Presentation: Salt Lake City, USA
  • Year and Date: 2009-03-24
• [Presentation] Programmed Assembly toward Photoconductive and Photovoltaic Nanomaterials (2009)
  • Author(s): T.Aida
  • Organizer: Swiss Chemical Society Spring Meeting 2009
  • Place of Presentation: Neuchatel, Switzerland
  • Year and Date: 2009-02-11
• [Presentation] Molecular Design of π-Conjugated Molecules for Material Science (2008)
  • Author(s): D.Miyajima, K.Tashiro, and T.Aida
  • Organizer: The 8th International Symposium on Functional π-Electron Systems
  • Place of Presentation: Graz, Austria
  • Year and Date: 2008-07-22
• [Remarks]
  • URL: http://macro.chem.t.u-tokyo.ac.jp/AIDA_LABORATORY/TOP.html