2012 Fiscal Year Final Research Report
Cytoplasmic RNA granules for intracellular mRNA localization and translational control
| Project Area | Diversity and asymmetry achieved by RNA program |
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| Project/Area Number |
20112002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAMURA Akira 独立行政法人理化学研究所, 生殖系列研究室, 特別主幹研究員 (90323245)
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| Research Collaborator |
加藤 容子 独立行政法人理化学研究所, 研究員
羽生 賀津子 (中村 賀津子) 独立行政法人理化学研究所, 研究員 (日本学術振興会・特別研究員 RPD)
白江 麻貴 (倉林 麻貴) 独立行政法人理化学研究所, 研究員
松田 一起 独立行政法人理化学研究所, テクニカルスタッフ
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| Project Period (FY) |
2008 – 2012
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| Keywords | ショウジョウバエ / 生殖質 / 生殖顆粒 / 生殖細胞 / RNA 局在 / RNP / 翻訳制御 / 細胞骨格 |
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| Research Abstract |
We conducted detailed analyses for germ plasm assembly and maintenance, and proposed several new ideas and concepts on RNA regulation. First, our analyses revealed that Edc3, a component of cytoplasmic RNP granules, mediates a dynamic remodeling of RNP components during localization and translation of germ plasm RNAs. We also found that the vesicle trafficking pathway promotes actin remodeling and plays a crucial role in the cortical anchorage of the germ plasm. Furthermore, our results show that the protection of germ plasm RNAs from the miRNA-mediated RNA degradation pathway is an evolutionally conserved process.
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[Journal Article] The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction.2012
Author(s)
Pradhan, S. J., Nesler, K. R., Rosen, S. F., Kato, Y., Nakamura, A., Ramaswami, M. and Barbee, S. A.
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Journal Title
J. Cell Sci.
Volume: 125
Pages: 6105-6116
Peer Reviewed
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[Journal Article] Membrane protein localization-dependent regulation by PI3K(III) and Rabenosyn-5 in Drosophila wing cells.2009
Author(s)
Abe, M., Setoguchi, Y., Tanaka, T., Awano, W., Takahashi, K., Ueda, R., Nakamura, A. and Goto, S.
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Journal Title
PLoS ONE
Volume: 4
Pages: e7306
Peer Reviewed
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[Journal Article] Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation.
Author(s)
Yamada, K., Fuwa, T., Ayukawa, T., Tanaka, T., Nakamura, A., Baron, M. and Matsuno, K.
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Journal Title
Genes Cells
Volume: 16
Pages: 1365-2443
Peer Reviewed
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