2012 Fiscal Year Final Research Report
Digital Image Analysis for Intracellular Logistics
| Project Area | Intracellular logistics: interdisciplinary approaches to pathophysiology of membrane traffic |
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| Project/Area Number |
20113007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKEMOTO Satoko 独立行政法人理化学研究所, 生物情報基盤構築チーム, 特別研究員 (00450403)
YOSHIZAWA Shin 独立行政法人理化学研究所, 生物情報基盤構築チーム, 副チームヘッド (10455371)
NISHIMURA Masaomi 独立行政法人理化学研究所, 生物基盤構築チーム, リサーチアソシエイト (50392064)
YOKOTA Hideo 独立行政法人理化学研究所, 生物情報基盤構築チーム, チームヘッド (00261206)
SOGA Kohei 東京理科大学, 基礎工学部, 教授 (50272399)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 細胞内画像処理 / 画像処理統合プラットフォーム / エキスパートシステム / 領域抽出 / 輸送担体追跡 / 細胞観察システム / 近赤外光 / アップコンバージョン粒子 |
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| Research Abstract |
Recent advances in image acquisition technology on intracellular logistics demand new computational methods for quantitative analysis of intracellular images. In this research, we have proposed several new image processing algorithms and a long time-lapse imaging system in order to meet the demand. We have also developed a biologist-friendly software based on the proposed algorithms and made it available on the WWW without compensation.
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[Journal Article] Local Nucleosome Dynamics Facilitate Chromatin Accessibility in Living Mammalian Cells.2012
Author(s)
Hihara S, Pack C.-G, Kaizu K, Tani T, Hanafusa T, Nozaki T, Takemoto S, Yoshimi T, Yokota H, Imamoto N, Sako Y, Kinjo M, Takahashi K, Nagai T and Maeshima K.
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Journal Title
Cell Reports
Volume: 2(6)
Pages: 1645-1656
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[Journal Article] In Vivo Imaging of Hierarchical Spatiotemporal Activation of Caspase-8 during Apoptosis.2012
Author(s)
Kominami K, Nagai T, Sawasaki T, Tsujimura Y, Yashima K, Sunaga Y, Tsuchimochi M, Nishimura J, Chiba K, Nakabayashi J, Koyamada K, Endo Y, Yokota H, Miyawaki A, Manabe N, and Sakamaki K.
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Journal Title
PLoS One
Volume: 7(11)
Pages: e50218:1-18
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[Journal Article] Nuclear pore formation but not nuclear growth is governed by cyclin-dependent kinases (Cdks) during interphase.2010
Author(s)
Maeshima K, Iino H, Hihara S, Funakoshi T, Watanabe A, Nishimura M, Nakatomi R, Yahata K, Imamoto F, Hashikawa T, Yokota H and Imamoto N.
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Journal Title
Nature Structural & Molecular Biology
Volume: 17
Pages: 1065-1071
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