Functional Organization of the Genome

2010 Fiscal Year Self-evaluation Report

• Project Area: The physicochemical field for genetic activities
• Project/Area Number: 20114002
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Osaka University
• Principal Investigator: HIRAOKA Yasushi Osaka University, 大学院・生命機能研究科, 教授 (10359078)
• Project Period (FY): 2008 – 2012
• Keywords: 分子細胞生物学

Research Abstract

真核生物のゲノムは染色体として細胞核に収納され継承される。体細胞分裂と減数分裂では細胞核内の染色体の空間配置が大きく異なる。このことから、遺伝情報を制御するダイナミックな時空間場を着想するに至った。本研究の目的は、遺伝情報の正確な継承を保証する時空間場の特性を明らかにし、継承のメカニズムを分子レベルで理解することにある。主に分裂酵母や動物培養細胞を用い、分子遺伝学的な手法と蛍光イメージングを併用して解析を進める。

Research Products

• [Journal Article] A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms (2011)
  • Author(s): Y.Chen, 他14名(10番目)
  • Journal Title: Nat.Struct.Mol. Biol 18 Pages: 213-221
  • Peer Reviewed
• [Journal Article] Spatio-temporal regulations of Weel at the G2-M transition (2011)
  • Author(s): H.Masuda, C.S.Fong, C.Ohtsuki, T. Haraguchi, Y.Hiraoka
  • Journal Title: Mol.Biol. Cell 22 Pages: 555-569
  • Peer Reviewed
• [Journal Article] Symmetry, asymmetry, and kinetics of silencing establishment in Saccharomyces cerevisiae revealed by single-cell optical assays (2011)
  • Author(s): E.A.Osborne, Y.Hiraoka, J.Rine
  • Journal Title: Proc Natl.Acad.Sci.USA 108 Pages: 1209-1216
  • Peer Reviewed
• [Journal Article] Nuclear envelope attachment is not necessary for telomere function in fission yeast (2010)
  • Author(s): Y.Chikashige, T.Haraguchi, Y. Hiraoka
  • Journal Title: Nucleus 1 Pages: 481-486
  • Peer Reviewed
• [Journal Article] Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated Nuclear Receptor Ad4BP/SF-1 (2009)
  • Author(s): H.Ogawa, T.Komatsu, Y.Hiraoka, K.Morohashi
  • Journal Title: Mol.Biol.Cell 20 Pages: 4235-4245
  • Peer Reviewed
• [Journal Article] Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation (2009)
  • Author(s): Y.Chikashige, M.Yamane, K.Okamasa, C.Tsutsumi, T.Kojidani, M.Sato, T. Haraguchi, Y.Hiraoka
  • Journal Title: J. Cell Biol 187 Pages: 413-427
  • Peer Reviewed
• [Journal Article] The SUN rises on meiotic chromosome dynamics (2009)
  • Author(s): Y.Hiraoka, A.Dernburg
  • Journal Title: Developmental Cell 17 Pages: 598-605
  • Peer Reviewed
• [Journal Article] Localization of gene products using a chromosomally-tagged GFP-fusion library in the fission yeast Schizosaccahromyces pombe (2009)
  • Author(s): A.Hayashi, D.-Q.Ding, C.Tsutsumi, Y.Chikashige, H.Masuda, T.Haraguchi, Y.Hiraoka
  • Journal Title: Genes Cells 14 Pages: 217-225
  • Peer Reviewed
• [Journal Article] Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly (2008)
  • Author(s): T.Haraguchi, T.Ko jidani, T.Kou jin, T.Shimi, H.Osakada, C.Mori, A. Yamamoto, Y.Hiraoka
  • Journal Title: J.Cell Sci 121 Pages: 2540-2554
  • Peer Reviewed
• [Patent(Industrial Property Rights)] Vrk1蛋白質抗体とその製造方法、抗原、検知方法 (2009)
  • Inventor(s): 原口徳子, 荒神尚子, 平岡泰
  • Industrial Property Rights Holder: 独立行政法人情報通信研究機構
  • Industrial Property Number: 特許,特願2009-155028
  • Filing Date: 2009-06-30