Regulatory mechanisms for the sensory processing in the neuronal circuit

2012 Fiscal Year Final Research Report

• Project Area: Systems molecular ethology to understand the operating principle of the nervous system
• Project/Area Number: 20115003
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyushu University
• Principal Investigator: ISHIHARA Takeshi 九州大学, 大学院・理学研究院, 教授 (10249948)
• Co-Investigator(Renkei-kenkyūsha): 藤原 学 九州大学, 大学院・理学研究院, 助教 (70359933) ; 広津 崇亮 九州大学, 大学院・理学研究院, 助教 (70404035) ; 寺本 孝行 九州大学, 大学院・理学研究院, 学術研究員 (90571836) ; 猿渡 悦子 九州大学, 基幹教育院, 助教 (60456605)
• Project Period (FY): 2008 – 2012
• Keywords: 情報処理 / 中枢神経 / 線虫 / イメージング

Research Abstract

Animals process sensory information in neuronal circuits for proper behavior. In this research, we identified signaling molecules and neurons to regulate sensory integration of cross modal stimuli and, depending on those results, we proposed a neuronal circuit model to regulate the behavioral choice. By analyzing mutants showing the prolonged retention of memory, we found that forgetting is accelerated by neuronal communication.

Research Products

• [Journal Article] Forgetting in C. elegans is accelerageted by neuronal communication via the TIR-1/JNK-1 pathway (2013)
  • Author(s): Inoue, A., Sawatari, E., Hisamoto, N., Kitazono, T., Teramoto, T., Fujiwara, M., Matsumoto, K., Ishihara, T
  • Journal Title: Cell Reports Volume: 3(3) Pages: 808-819
  • DOI: doi:10.1016/j.celrep
  • Peer Reviewed
• [Journal Article] A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer (2013)
  • Author(s): Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S., Koshiba, T
  • Journal Title: Biochimica et Biophysica Acta Volume: 1833(5) Pages: 1017-1027
  • DOI: doi:10.1016/j.bbamcr
  • Peer Reviewed
• [Journal Article] Temporally -regulated quick activation and inactivation of Ras is important for olfactory behaviour (2012)
  • Author(s): Uozumi, T., Hirotsu, T., Yoshida, K., Yamada, R., Suzuki, A., Taniguchi, G., Iino, Y., Ishihara, T
  • Journal Title: Scientific Reports Volume: 2 Pages: 500
  • DOI: doi:10.1038/srep00500
  • Peer Reviewed
• [Journal Article] Odour concentration -dependent olfactory preference change in C. elegans (2012)
  • Author(s): Yoshida, K., Hirotsu, T., Tagawa, T., Oda, S., Wakabayashi, T., Iino, Y., Ishihara, T
  • Journal Title: Nature Communications Volume: 3 Pages: 739
  • DOI: doi:10.1038/ncomms1750
  • Peer Reviewed
• [Journal Article] An expanded palette of genetically encoded Ca^<2+> indicators (2011)
  • Author(s): Zhao, Y., Araki, S., Wu, J., Teramoto, T., Chang,YF., Nakano, M., Abdelfattah AS., Fujiwara, M., Ishihara, T., Nagai, T. CampbellRE
  • Journal Title: Science Volume: 333(6051) Pages: 1888-1891
  • DOI: doi10.1126/science.1208592
  • Peer Reviewed
• [Journal Article] Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans. J (2011)
  • Author(s): Shinkai, Y., Yamamoto,Y., Fujiwara, M., Tabata, T. , Murayama T., Hirotsu, T. , Ikeda, D., Tsunozaki, M., Iino, Y., Bargmann, C., Katsura, I., and Ishihara, T
  • Journal Title: Neuroscience Volume: 31(8) Pages: 3007-3015
  • DOI: doi:10.1523/JNEUROSCI.4691-10.2011
  • Peer Reviewed
• [Journal Article] A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of C. elegans (2010)
  • Author(s): Fujiwara, M., Teramoto, T., Ishihara, T., Ohshima Y. and McIntire, S. L
  • Journal Title: PLoS Genetics Volume: 6 Pages: e1001211
  • DOI: doi:10.1371/journal.pgen.1001211
  • Peer Reviewed
• [Journal Article] Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans (2010)
  • Author(s): Yamada, K., Hirotsu, T., Matsuki, M., Butcher R.A., Tomioka, M., Ishihara, T., Clardy J., Kunitomo, H., Iino, Y
  • Journal Title: Science Volume: 329 Pages: 1647-1650
  • DOI: doi:10.1126/science.1192020
  • Peer Reviewed
• [Journal Article] Behavioural assay for olfactory plasticity in C. elegans (2009)
  • Author(s): Hirotsu, T., Hayashi, Y., Iwata, R., Kunitomo, H., Kage-Nakadai, E., Kubo, T., Ishihara, T. and Iino, Y
  • Journal Title: Nature Protocols Volume: 139
  • DOI: doi:10.1038/nprot.2009.139
• [Journal Article] A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans (2009)
  • Author(s): Hayashi, Y., Hirotsu, T., Iwata, R., Kage-Nakadai, E., Kunitomo, H., Ishihara, T., Iino, Y. and Kubo, T
  • Journal Title: Nature Neuroscience Volume: 12 Pages: 981-987
  • DOI: doi:10.1038/nn.2347
  • Peer Reviewed
• [Journal Article] FLR-2, the glycoprotein hormone alpha subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans (2009)
  • Author(s): Oishi, A., Gengyo-Ando, K., Mitani, S., Mohri-Shiomi, A., Kimura,K.D., Ishihara, T., Katsura, I
  • Journal Title: Genes to Cells Volume: 14 Pages: 1141-1154
  • DOI: doi:10.1111/j.1365-2443.2009.01341.x
  • Peer Reviewed
• [Presentation] 4-D Ca2+イメージングによる線虫C. elegans の行動選択を制御する複数ニューロンの活動の可視化と計測 (2012)
  • Author(s): 寺本 孝行、山本 悠太、 石原 健
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-14
• [Presentation] 線虫の成長に伴う行動変化に関わるミトコンドリアの働き (2012)
  • Author(s): 藤原 学、佐藤 則子、石原 健
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] 線虫C. elegans におけるcGMP 依存性タンパク質キナーゼ EGL-4 による特定の匂いへの走性制御機構の解析 (2012)
  • Author(s): 有井 照剛、藤原 学、石原 健
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-12-13
• [Presentation] 線虫C. elegans を用いた忘却シグナルの探索 (2012)
  • Author(s): 北園 智弘、井上明俊、石原 健
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] 線虫C. elegans において記憶の忘却はASK/JNK 経路を介した神経間シグナル分泌により促進される (2012)
  • Author(s): 井上 明俊、猿渡悦子、寺本 孝行、石原 健
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-11
• [Presentation] Acceleration of forgetting by neuronal communication in C. elegans (2012)
  • Author(s): 石原 健
  • Organizer: INTERNATIONAL SYMPOSIUM ON ORGANIZATION AND FUNCTION OF THE NERVOUS SYSTEM
  • Place of Presentation: 東京大学
  • Year and Date: 2012-11-27
• [Presentation] 線虫C. elegans の神経回路における忘却の制御機構 (2012)
  • Author(s): 石原 健
  • Organizer: 記憶回路研究会
  • Place of Presentation: 岡崎
  • Year and Date: 2012-11-21
• [Presentation] 線虫C. elegans を用いた忘却シグナルの探索 (2012)
  • Author(s): 北園 智弘、井上 明俊、石原 健
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 九州大学
  • Year and Date: 2012-09-24
• [Presentation] 生殖細胞が制御する線虫の感覚行動 (2012)
  • Author(s): 藤原 学、佐藤 則子、石原 健
  • Organizer: 日本遺伝学会第84回大会
  • Place of Presentation: 九州大学
  • Year and Date: 2012-09-24
• [Presentation] 線虫の行動選択を制御する神経回路とその活動の可視化 (2012)
  • Author(s): 石原 健
  • Organizer: 文部科学省新学術領域研「システム分子行動学」班会議
  • Place of Presentation: 仙台
  • Year and Date: 2012-07-26
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2012)
  • Author(s): Fujiwara M., Sato N, Maruyama S, Ishihara T
  • Organizer: EMBO Conference Series C.elegans Neurobiology
  • Place of Presentation: EMBL Heidelberg, Germany
  • Year and Date: 2012-06-16
• [Presentation] snt-3 regulates memory erasing for butanone enhancement in Caenorhabditis elegans (2012)
  • Author(s): Sawatari E., Kaieda K., Teramoto T., Ishihara T
  • Place of Presentation: EMBL Heidelberg, Germany
  • Year and Date: 2012-06-16
• [Presentation] Forgetting in C. elegans is accelerated by neuronal communication via the p38 MAPK pathway (2012)
  • Author(s): Inoue A. , Sawatari E., Teramoto,T. Ishihara T
  • Place of Presentation: EMBL Heidelberg, Germany
  • Year and Date: 2012-06-15
• [Presentation] 4-D Ca2+ imaging of the multiple neurons that regulate the sensory integration underlying behavioral choice (2012)
  • Author(s): Teramoto T., Yamamoto Y., and Ishihara T
  • Place of Presentation: EMBL Heidelberg, Germany
  • Year and Date: 2012-06-14
• [Presentation] Changes in responsivity of olfactory neurons to odor during olfactory adaptation and recovery in Caenorhabditis elegans (2011)
  • Author(s): Swatari E. Kaieda K. Ishihara T
  • Organizer: 18th International C.elegans Meeting
  • Place of Presentation: Los Angeles U.S.A.
  • Year and Date: 20110622-26
• [Presentation] Chemotaxis behavior is regulated by germline in C. elegans (2011)
  • Author(s): Fujiwara M., Ishihara T
  • Organizer: 18th International C.elegans Meeting
  • Place of Presentation: Los Angeles U.S.A.
  • Year and Date: 20110622-26
• [Presentation] The P38/JNK MAP kinase pathway regulates forgetting in Caenorhabditis elegans (2011)
  • Author(s): Inoue A., Ishihara T
  • Organizer: 18th International C.elegans Meeting
  • Place of Presentation: Los Angeles U.S.A.
  • Year and Date: 20110622-26
• [Presentation] 線虫C. elegans における感覚情報の統合の分子メカニズムの解析 (2011)
  • Author(s): 山本 悠太、新海 陽一、猿渡 悦子、寺本 孝行、石原 健
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] 4D in vivo Ca^<2+> imaging of the C. elegans neural network (2011)
  • Author(s): 寺本 孝行、石原 健
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-13
• [Presentation] Molecular and neural mechanisms of behavioral choice in C. elegans (2011)
  • Author(s): Ishihara, T
  • Organizer: Systems Molecular Ethology and Beyond
  • Place of Presentation: 東京大学
  • Year and Date: 2011-11-10
• [Presentation] 線虫C.elegansの行動選択に関わる感覚情報の統合を制御するメカニズム (2011)
  • Author(s): 石原 健、新海 陽一、山本 悠太、寺本 孝行
  • Organizer: 日本神経科学大会 シンポジウム「化学感覚の情報処理の分子神経機構」S4-G-1-3
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] C.elegan s神経ネットワークの4次元Ca2+イメージング (2011)
  • Author(s): 寺本 孝行、石原 健
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Molecular and neural mechanisms for behavioral choice between two conflicting alternatives in C. elegans (2011)
  • Author(s): Ishihara, T
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics
  • Place of Presentation: Hilton Niseko Village,Hokkaido, Japan
  • Year and Date: 2011-06-12
• [Presentation] The P38/JNK MAP kinase pathway regulates forgetting in Caenorhabditis elegans (2010)
  • Author(s): Inoue, A. and Ishihara, T
  • Organizer: NEURONAL DEVELOPMENT,SYNAPTIC FUNCTION & BEHAVIOR C.elegans Topic Meeting
  • Place of Presentation: Madison,USA
  • Year and Date: 20100626-0702
• [Presentation] 線虫の神経回路における感覚情報の統合と記憶の忘却のメカニズム (2010)
  • Author(s): 石原 健
  • Organizer: 日本分子生物学会第10回春季シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 20100607-09
• [Presentation] MOLECULAR ANALYSES OF THE INTEGRATION OF TWO SENSORY SIGNALS IN C. ELEGANS (2010)
  • Author(s): Shinkai,Y. and Ishihara, T
  • Organizer: 2010 Cold Spring Harbor Laboratory Meeting on Neuronal Circuit
  • Place of Presentation: Cold Spring Harbor U.S.A.
  • Year and Date: 2010-03-10
• [Presentation] 線虫C.elegansにおけるブタノンエンハンスメントに関わる記憶の消去の解析 (2009)
  • Author(s): 海江田 兼次、石原 健
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] 線虫を用いた記憶を忘れるメカニズムの遺伝学的解析 (2009)
  • Author(s): 井上 明俊、石原 健
  • Organizer: 第32回日本分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 20091209-12
• [Presentation] Chemotactic control by a germline signal in C. elegans (2009)
  • Author(s): Fujiwara, M., Sato, N., Maruyama, S., Akamine, T. and Ishihara, T
  • Organizer: 17th International C.elegans Meeting
  • Place of Presentation: Los Angeles U.S.A.
  • Year and Date: 20090624-28
• [Presentation] Molecular analysis of the integration of two sensory signals in C. elegans (2009)
  • Author(s): Shinkai,Y.,and Ishihara, T
  • Organizer: 17th International C.elegans Meeting
  • Place of Presentation: Los Angeles U.S.A.
  • Year and Date: 20090624-28
• [Presentation] 線虫C. elegans におけるブタノンエンハンスメントに関わる記憶の消去の解析 (2008)
  • Author(s): 海江田 兼次、石原 健
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 20081209-12
• [Remarks]
  • URL: http://www.biology.kyushu-u.ac.jp/~bunsiide/
• [Remarks] H25.4.25 「卓上四季」北海道新聞(朝刊)
• [Remarks] H25.4.12 「積極的に記憶の消去促す神経細胞と制御機構発見」科学新聞
• [Remarks] H25.3.25 「記憶忘却促す細胞発見」産経新聞(朝刊)
• [Remarks] H25.3.22 「記憶を忘れさせる細胞」西日本新聞(朝刊)
• [Remarks] H25.3.22 「記憶忘却促す神経細胞」日本経済新聞(夕刊)
• [Remarks] H25.3.22 「忘却の仕組み解明へ」毎日新聞(朝刊)
• [Remarks] H25.3.22 「記憶の忘却促す細胞を発見」共同通信
• [Remarks] H25.3.22 「記憶の忘却促す細胞を発見」東京新聞