2012 Fiscal Year Final Research Report
Molecular basis for structure and function of memory circuits in Drosophila
| Project Area | Systems molecular ethology to understand the operating principle of the nervous system |
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| Project/Area Number |
20115005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TABATA Tetsuya 東京大学, 分子細胞生物学研究所, 教授 (10183865)
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| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Satoshi 東京大学, 分子細胞生物学研究所, 助教 (10463902)
YASUGI Tetsuo 東京大学, 分子細胞生物学研究所, 助教 (90508110)
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| Project Period (FY) |
2008 – 2012
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| Keywords | ショウジョウバエ / 記憶 / mushroom body / Ca2+イメージング / CREB / 記憶痕跡 / 匂いコーディング |
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| Research Abstract |
Olfactory information in Drosophila is conveyed by projection neurons from olfactory sensory neurons to Kenyon cells (KCs) in the mushroom body. KCs function as coincidence detectors for memory formation, associating odor information with a coincident punishment or reward stimulus. We monitored the neuronal activity after training flies under the microscope with the calcium indicator GCaMP and identified olfactory memory traces in the KCs and in 4th-order neurons that innervate KCs. We also identified the genes required for olfactory memory formation by studying transcriptome of KCs and identified a group of cells required for memory formation by devising a CREB reporter gene.
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[Journal Article] Concentric zones, cell migration and neuronal circuits in the Drosophila visual center2011
Author(s)
Hasegawa, E., Kitada, Y., Kaido, M., Takayama, R.,Awasaki, T.,Tabata, T.,and Sato, M equal contribution
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Journal Title
Development
Volume: 138
Pages: 983-993
Peer Reviewed
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[Journal Article] Optimizing Drosophila Olfactory Learning with a Semi-automated Training Device2010
Author(s)
Murakami, S., Dan, C., Zagaeski, B., Maeyama, Y., Kunes, S., and Tabata, T
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Journal Title
Journal of Neuroscience Methods
Volume: 188
Pages: 195-204
Peer Reviewed
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