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2012 Fiscal Year Final Research Report

Interpretation of biological behavior from a systems engineering point of view and its application to biomimetic sensor systems

Planned Research

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Project AreaSystems molecular ethology to understand the operating principle of the nervous system
Project/Area Number 20115010
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHiroshima University

Principal Investigator

TSUJI Toshio  広島大学, 大学院・工学研究院, 教授 (90179995)

Co-Investigator(Kenkyū-buntansha) TANAKA Yoshiyuki  広島大学, 大学院・工学研究院, 助教 (40336920)
TAKIGUCHI Noboru  金沢大学, 理工研究域・自然システム学系, 准教授 (20304462)
SUZUKI Michiyo  日本原子力研究開発機構, 量子ビーム応用研究部門, 研究員 (10507437)
Co-Investigator(Renkei-kenkyūsha) OHTAKE Hisao  大阪大学, 大学院・工学研究科, 教授 (10127483)
Project Period (FY) 2008 – 2012
Keywords生物模倣型センサシステム / 化学受容 / 刺激応答 / 線虫の神経-筋モデル / マウスの嗅神経系モデル / バイオアッセイシステム / 呼吸波
Research Abstract

This study revealed paths of signal transduction regarding radiation stimulus of Caenorhabditis elegans (C. elegans) and constructed mathematical models of C. elegans to enable analysis of the mechanisms behind chemotaxis and rhythm generation. Mathematical models of the olfactory system were also constructed based on biological insight regarding mice and rats, and the study enabled simulation for selective attention in relation to odorant components, prediction of neural responses on the glomerular layer of the olfactory bulb, and prediction of perceptive similarities between odorants based on glomerular responses. Further, a bioassay system incorporating the use of small fish was created to allow immediate detection of water contamination.

  • Research Products

    (16 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] 小型魚類の水質汚染監視用バイオアッセイシステムの開発2013

    • Author(s)
      曽 智,宮本健太郎,平野 旭,栗田雄一,辻 敏夫
    • Journal Title

      電気学会論文誌 C(電子・情報・システム部門誌)

      Volume: 133(掲載確定)

    • Peer Reviewed
  • [Journal Article] A bioassay system based on behavioral analysis and bioelectric ventilatory signals of a small fish2013

    • Author(s)
      Soh, Z., Kitayama, S., Hirano, A., and Tsuji, T
    • Journal Title

      IEEE Trans. Instrum. Meas

      Volume: 62(掲載確定)

    • Peer Reviewed
  • [Journal Article] 呼吸波計測に基づく小型魚類遊泳行動の非接触・非拘束計測2012

    • Author(s)
      来山 茂央,曽 智,平野旭,辻敏夫,滝口 昇,大竹久夫
    • Journal Title

      計測自動制御学会論文集

      Volume: 48 Pages: 151-158

    • Peer Reviewed
  • [Journal Article] Modeling of the pharyngealmuscle in Caenorhabditis elegans based on FitzHugh-Nagumo equations2012

    • Author(s)
      Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y., and Tsuji, T
    • Journal Title

      Artif. Life Robotics

      Volume: 17 Pages: 173-179

    • Peer Reviewed
  • [Journal Article] Theoretical and evolutionary parameter tuning of neural oscillators with a double-chain structure for generating rhythmic signals2012

    • Author(s)
      Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y., and Tsuji, T
    • Journal Title

      Neural. Comp

      Volume: 24 Pages: 635-675

    • Peer Reviewed
  • [Journal Article] 小型魚類の生体電気信号を利用したバイオアッセイシステムの提案2011

    • Author(s)
      寺脇充,曽智,平野 旭,辻敏夫
    • Journal Title

      計測自動制御学会論文集

      Volume: 47 Pages: 119-125

    • Peer Reviewed
  • [Journal Article] An artificial neural network approach for glomerular activity pattern prediction using the graph kernel method and the Gaussian mixture functions2011

    • Author(s)
      Soh, Z., Tsuji, T., Takiguchi, N., and Ohtake, H
    • Journal Title

      Chem. Sens

      Volume: 36 Pages: 413-424

    • Peer Reviewed
  • [Journal Article] Neuro-based olfactory model for artificial organoleptic tests2010

    • Author(s)
      Soh, Z., Tsuji, T., Takiguchi, N., and Ohtake, H
    • Journal Title

      Artif. Life Robotics

      Volume: 14 Pages: 474-479

    • Peer Reviewed
  • [Journal Article] Unconstrained and noninvasive measurement of bioelectric signals from small fish2010

    • Author(s)
      Terawaki, M., Hirano, A., Soh Z., and Tsuji, T
    • Journal Title

      Artif. Life Robotics

      Volume: 14 Pages: 342-347

    • Peer Reviewed
  • [Journal Article] Biomimetic control based on a model of chemotaxis in Escherichia coli2010

    • Author(s)
      Tsuji, T., Suzuki, M., Takiguchi, N., and Ohtake, H
    • Journal Title

      Artif. Life

      Volume: 16 Pages: 155-177

    • Peer Reviewed
  • [Journal Article] 生物行動のシステム論的解釈と工学応用-線虫、ラット、メダカを手掛かりとして-2010

    • Author(s)
      辻 敏夫,鈴木芳代,曽 智,寺脇 充,滝口 昇,大竹久夫
    • Journal Title

      ソフトウェアバイオロジー

      Volume: 9 Pages: 3-12

  • [Journal Article] Effects of ionizing radiation on locomotory behavior and mechanosensation in Caenorhabditis elegans2009

    • Author(s)
      Suzuki, M., Sakashita, T., Yanase, S., Kikuchi, M., Ohba, H., Higashitani, A., Hamada, N., Funayama, T., Fukamoto, K., Tsuji, T., and Kobayashi, Y
    • Journal Title

      J. Radiat. Res

      Volume: 50 Pages: 119-125

    • Peer Reviewed
  • [Book] Computational Inferences on Alteration of Neurotransmission in Chemotaxis Learning in Caenorhabditis elegans, In: Diamantaras, K., Duch, W., and Iliadis, L.S. (Eds.), Artificial Neural Networks -ICANN 20102010

    • Author(s)
      Suzuki, M., Sakashita, T., Tsuji, T., and Kobayashi, Y
    • Total Pages
      6352, 291-300
    • Publisher
      Lecture Notes in Computer Science
  • [Book] A Novel Tuning Method for Neural Oscillators with a Ladder-like Structure based on Oscillation Analysis, In: Diamantaras, K., Duch, W., and Iliadis, L.S. (Eds.), Artificial Neural Networks -ICANN 20102010

    • Author(s)
      Hattori, Y., Suzuki, M., Soh, Z., Kobayashi, Y., and Tsuji, T
    • Total Pages
      6352, 401-410
    • Publisher
      Lecture Notes in Computer Science
  • [Remarks]

    • URL

      http://www.bsys.hiroshima-u.ac.jp/

  • [Patent(Industrial Property Rights)] 水質検査システムおよび魚類監視システム2013

    • Inventor(s)
      辻敏夫、曽智、栗田 雄一、宮本 健太郎
    • Industrial Property Rights Holder
      広島大学
    • Industrial Property Number
      特許、特願 2013-051916
    • Filing Date
      2013-03-14

URL: 

Published: 2014-08-29  

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