2013 Fiscal Year Final Research Report
Investigation of GSC/niche system in the mouse testis
| Project Area | Regulatory Mechanism of Gamete Stem Cells |
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| Project/Area Number |
20116004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
YOSHIDA Shosei 基礎生物学研究所, 生殖細胞研究部門, 教授 (60294138)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Yukihiko 熊本大学, 医学薬学研究部, 教授 (80243038)
KITADATE Yu 基礎生物学研究所, 生殖細胞研究部門, 助教 (10455214)
HARA Kenshiro 基礎生物学研究所, 生殖細胞研究部門, 助教 (60551546)
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| Project Period (FY) |
2008-11-13 – 2013-03-31
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| Keywords | 配偶子 / 幹細胞 / ニッチ / マウス / 精巣 |
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| Research Abstract |
The aim of this study is to elucidate the nature of mouse GSC (spermatogenic stem cells), as well as their niche and niche cells. By using originally developed experimental systems, we have investigated the behavior of stem spermatogonia in undisturbed testes. (1) Discovery of hierarchy and reversibility within the stem cell compartment, (2) discovery of frequent loss and replacement of stem cells, and (3) elucidation of the GSC dynamics at a single cell resolution together lead us to propose a model that would challenge the prevailing theory that wasproposed in 1971.
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[Journal Article] An epigenetic switch is crucial for spermatogonia to exit the undifferentiated state toward a Kit-positive identity2013
Author(s)
T.Shirakawa, R.Yaman-Deveci, S.Tomizawa, Y.Kamizato, K.Nakajima, H.Sone, Y.Sato, J.Sharif, A.Yamashita, Y.Takada-Horisawa, S.Yoshida, K.Ura, M.Muto, H.Koseki, T.Suda and K.Ohbo
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Journal Title
Development
Volume: 140
Pages: 3565-3576
DOI
Peer Reviewed
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[Presentation] Sperm stem cells in the mouse2012
Author(s)
S.Yoshida
Organizer
Keystone Symposia on Molecular and Cellular Biology, "The Life of a Stem Cell : From Birth to Death"
Place of Presentation
Resort at Squaw Creek, Olympic Valley, USA
Year and Date
20120311-16
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[Presentation] Gamete stem cells2010
Author(s)
S.Yoshida
Organizer
43rd Annual Meeting for the Japanese Society of Developmental Biologists Jointly Sponsored by the Asia-Pacific Developmental Biology Network
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan (オーガナイザー)
Year and Date
20100620-23
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[Remarks] 中日新聞(2012年3月7日16面)「精子の源」神秘に迫る 岡崎から挑む-自然科学研究機構の若手(2) 報道関連
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[Remarks] Newton(2010年6月号P120)膨大な量の精子をつくりつづけるしくみとは? 報道関連
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[Remarks] 基生研一般公開 2013年10月5日 アウトリーチ活動
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[Remarks] 基生研一般公開 2010年10月2日 アウトリーチ活動
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