2012 Fiscal Year Final Research Report
The mechanism underlying regulation of gamete stem cells/niche system in the sexual induction of planarians
| Project Area | Regulatory Mechanism of Gamete Stem Cells |
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| Project/Area Number |
20116007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Hirosaki University (2012)
Keio University (2008-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Midori 慶應義塾大学, 理工学部, 准教授 (00211574)
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| Co-Investigator(Renkei-kenkyūsha) |
AGATA Kiyokazu 京都大学, 理学研究科, 教授 (70167831)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 配偶子形成 / 幹細胞 / ニッチ / 生殖様式 / プラナリア |
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| Research Abstract |
Asexual planarians of Dugesia ryukyuensis can develop the hermaphroditic reproductive organs, if they are fed with sexual planarians of the different as well as the same species; this means that they contain sex-inducing substances that are not species-specific. The sex-inducing substances may induce the gamete stem cells/niche system from the pluripotent stem cells called neoblasts. In this study, we established the molecular basis for understanding the mechanism underlying regulation of gamete stem cells/niche system in the planarian ovary. Otherwise, we obtained a more purified fraction including D-Trp with a strong sex-inducing activity. D-Trp, which has been identified as an ovarian inducing substance, may give rise to a strong sex-inducing activity with the substances containing in the fraction.
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[Journal Article] The Dr-nanos gene is essential for germ cell specification in the planarian Dugesia ryukyuensis, Int2012
Author(s)
Nakagawa, H., Ishizu, H.,Chinone, A., Kobayashi, K., Matsumoto, M
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Journal Title
J. Dev. Biol
Volume: Vol.56
Pages: 165-171
Peer Reviewed
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[Presentation] D-amino acid oxidase represses the sexual induction in the planarian Dugesia ryukyuensis2011
Author(s)
Maezawa, T., Tanaka, H., Nakagawa, H., Horiike, K., Kobayashi, K
Organizer
Planarian Regeneration Research Meeting in Kyoto
Place of Presentation
Kyoto, Japan
Year and Date
2011-11-22
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[Presentation] Sexual induction by feeding in an asexual strain of the planarian, Dugesia ryukyuensis2011
Author(s)
Kobayashi, K.,Aoki, M., Hoshi, M., Matsumoto, M
Organizer
ryukyuensis,The 1st International Meeting on Planarian Biology
Place of Presentation
Munster, Germany
Year and Date
2011-05-27
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