2012 Fiscal Year Final Research Report
Regulatory mechanism for systems generating reactive-oxygen signals
| Project Area | Signaling functions of reactive oxygen species |
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| Project/Area Number |
20117002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | 活性酸素 / 蛋白質 / シグナル伝達 / 酵素 / NADPH オキシダーゼ |
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| Research Abstract |
Although ATP is essential for cell survival, efficient synthesis of ATP results in generation of reactive oxygen species (ROS) as inevitable deleterious by-products. ROS is highly reactive and thus induces cell and tissue damage; on the other hand, increasing attention has currently been paid to beneficial roles of ROS. For this purpose, there exist enzymes dedicated to ROS production, such as Nox family NADPH oxidases. In the present study, we have intensively studied ROS production by various types of Nox oxidases and clarified molecular mechanisms for Nox regulation.
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[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activatorDOCK22012
Author(s)
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H., Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y
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Journal Title
Chem. Biol
Volume: 19
Pages: 488-497
DOI
Peer Reviewed
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[Journal Article] Selectively induced apoptosis in human neutrophils in the presence of oxidative phenoxazines, 2 -amino-4, 4α-dihydryo-4α-7H-phenoxazine-3-one and 2 -aminophenoxazine-3-one preceded by decrease of intracellular pH, depolarization of the mitochondria and inhibition of superoxidegeneration2011
Author(s)
Tabuchi T, Ch, X-F, Hiraishi K, Adachi M, Miyano K, Sumimoto H , Tabuchi T, Miyazawa K, and Tomoda A
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Journal Title
J. Pharmacol. Sci
Volume: 117
Pages: 139-148
DOI
Peer Reviewed
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[Journal Article] Pertussis toxin upregulates angiotensin type 1 receptors through Toll-like receptor 4 -mediated Racactivation2010
Author(s)
Nishida M, Suda R, Nagamatsu Y, Tanabe S, Onohara N, Nakaya M, Kanaho Y, Shibata T, Uchida K, Sumimoto H, Sato Y, Kurose H
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 15268-15277
DOI
Peer Reviewed
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[Journal Article] Enhanced expression of NAPDH oxidase Nox4 in human gliomas and its roles in cell proliferation andsurvival2008
Author(s)
Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki S O, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, and Sasaki T
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Journal Title
Int. J. Cancer
Volume: 123
Pages: 787-792
DOI
Peer Reviewed
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[Journal Article] Characterization of teleost phagocyte NADPH oxidase: Molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase2008
Author(s)
Mayumi M, Takeda Y, Hoshiko M, Serada K, Murata M, Moritomo T, Takizawa F, Kobayashi I, Araki K, Nakanishi T, Sumimoto H
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Journal Title
Mol. Immunol
Volume: 45
Pages: 1720-1731
DOI
Peer Reviewed
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