2012 Fiscal Year Final Research Report
The roleof H_20_2as an endothelium-derived relaxing factors (EDRFs)
| Project Area | Signaling functions of reactive oxygen species |
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| Project/Area Number |
20117009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高等教育開発推進センター, 准教授 (80436120)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 血管内皮 / 内皮由来弛緩因子 / 一酸化窒素 / 過酸化水素 / 一酸化窒素合成酵素 |
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| Research Abstract |
Oxidative stress, generated by excessive reactive oxygen species (ROS) promotes cardiovascular disease. However, the precise mechanism how ROS (i.e., H_20_2,0_2', and 'OH)deteriorate vascular function and promote vascular remodeling has not been clearly elucidated. Moreover, H_20_2 also plays a crucial role as a signaling molecule under physiological conditions. Our recent study revealed that H_20_2 is one of the endothelium-derived hyperpolarizing factor (EDHF) that contributes as a signaling molecule in the Vasculature.
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Research Products
(26 results)
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[Journal Article] Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications and prognostic impact-Multicenter registry study of the Japanese Coronary Spasm Association-2013
Author(s)
Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, Matsui M, Goto T, Tanabe Y, Sueda S, Sato T, Ogawa S, Kubo N, Momomura S, Ogawa H, Shimokawa H
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Journal Title
Eur Heart J
Volume: 34
Pages: 258-267
DOI
Peer Reviewed
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[Journal Article] Plasma cyclophilin A is a novel biomarker for coronary artery disease2013
Author(s)
Satoh K, Fukumoto Y, Sugimura K, Miura Y, Aoki T, Nochioka K, Tatebe S, Miyamichi-Yamamoto S, Shimizu T, Osaki S,Takagi Y, Tsuburaya R, Ito Y, Matsumoto Y, Nakayama M, Takeda M, Takahashi J, Ito K, Yasuda S, Shimokawa H
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Journal Title
Circ J
Volume: 77
Pages: 447-455
DOI
Peer Reviewed
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[Journal Article] Long-term treatment with nifedipine suppresses coronary yperconstrcting responses and inflammatory changes induced by paclitaxel-eluting stent in pigs in vivo: Possible involvement of Rho- kinase pathway-2012
Author(s)
Tsuburaya R, Yasuda S, Shiroto T, Ito Y, Gao JY, Aizawa K, Kikuchi Y, Ito K, Takahashi J, Ishibashi-Ueda H, Shimokawa H
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Journal Title
Eur Heart J
Volume: 33
Pages: 791-799
DOI
Peer Reviewed
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