2012 Fiscal Year Final Research Report
Transcriptional regulation by reactive oxygen species
Project Area | Signaling functions of reactive oxygen species |
Project/Area Number |
20117010
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Hirosaki University |
Principal Investigator |
ITOH Ken 弘前大学, 医学(系)研究科(研究院), 教授 (10323289)
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Co-Investigator(Kenkyū-buntansha) |
SATOH Takumi 岩手大学, 工学部, 准教授 (10300831)
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Co-Investigator(Renkei-kenkyūsha) |
MIMURA Junsei 弘前大学, 医学(系)研究科(研究院), 講師 (60344884)
MARUYAMA Atsushi 弘前大学, 医学(系)研究科(研究院), 助教 (10431438)
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Project Period (FY) |
2008 – 2012
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Keywords | 活性酸素 / Nrf2 / ストレス応答 |
Research Abstract |
To clarify the transcription regulation in response to reactive oxygen species and its roles in pathophysiology, we analyzed it focusing on Nrf2. We identified KAP1, GCN1L1 and ATF4 as novel Nrf2-interacting proteins and showed that they cooperate with Nrf2 for the protection against oxidative stress. Furthermore, we have clarified that Nrf2 promotes atherosclerosis formation in the advanced stage of high fat diet-induced atherosclerosis model in mice.
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[Journal Article] Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells2013
Author(s)
Meng P, Yoshida H, Matsumiya T, Imaizumi T, Tanji K, Xing F, Hayakari R, Dempoya J, Tatsuta T, Aizawa-Yashiro T, Mimura J, Kosaka K, Itoh K, Satoh K
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Journal Title
Neurosci Res
Volume: 75
Pages: 4-102
DOI
Peer Reviewed
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[Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation2012
Author(s)
Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
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Journal Title
Free Radic Biol Med
Volume: 53
Pages: 2256-2262
DOI
Peer Reviewed
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47
Pages: 924-935
DOI
Peer Reviewed
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[Journal Article] Methylation of the KEAP1 gene promoter region in human colorectal cancer2012
Author(s)
Hanada N, Takahata T, Zhou Q, Ye X, Sun R, Itoh J, Ishiguro A, Kijima H, Mimura J, Itoh K, Fukuda S, Saijo Y
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Journal Title
BMC Cancer
Volume: 12
Pages: 66
DOI
Peer Reviewed
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[Journal Article] Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages2011
Author(s)
Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, Mimura J, Toki T, Maher JM, Yamamoto M, Itoh K
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Journal Title
Arch Biochem Biophys
Volume: 508
Pages: 101-109
DOI
Peer Reviewed
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[Journal Article] Edaravone and carnosic acid synergistically enhance the expression of nerve growth factor in human astrocytes under hypoxia/reoxygenation2011
Author(s)
Yoshida H, Mimura J, Imaizumi T, Matsumiya T, Ishikawa A, Metoki N, Tanji K, Ota K, Hayakari R, Kosaka K, Itoh K, Satoh K
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Journal Title
Neurosci Res
Volume: 69
Pages: 291-298
DOI
Peer Reviewed
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[Journal Article] Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene2010
Author(s)
Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE
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Journal Title
BMC Cancer
Volume: 10
Pages: 540
DOI
Peer Reviewed
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[Journal Article] Suppression of SLC11A2 Expression Is Essential to Maintain Duodenal Integrity During Dietary Iron Overload2010
Author(s)
Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S
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Journal Title
Am J Pathol
Volume: 177
Pages: 677-685
DOI
Peer Reviewed
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[Journal Article] Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of NF-E2-related factor 2 and oxidation of kelch-like ECH-associating protein 12009
Author(s)
Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Matsui H, Yoshikawa T
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Journal Title
J Pharmacol Exp Ther
Volume: 331
Pages: 255-264
DOI
Peer Reviewed
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[Journal Article] Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer2009
Author(s)
Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M
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Journal Title
Clin Cancer Res
Volume: 15
Pages: 3423-3432
DOI
Peer Reviewed
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[Journal Article] Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice2008
Author(s)
Yoh K, Hirayama A, Ishizaki K, Yamada A, Takeuchi M, Yamagishi S, Morito N, Nakano T, Ojima M, Shimohata H, Itoh K, Takahashi S, Yamamoto M
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Journal Title
Genes Cells
Volume: 13
Pages: 1159-1170
DOI
Peer Reviewed
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[Journal Article] Keap1 Regulates the Constitutive Expression of GST A1 during Differentiation of Caco-2 Cells2008
Author(s)
Kusano Y, Horie S, Shibata T, Satsu H, Shimizu M, Hitomi E, Nishida M, Kurose H, Itoh K, Kobayashi A, Yamamoto M, Uchida K
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Journal Title
Biochemistry
Volume: 47
Pages: 6169-77
DOI
Peer Reviewed
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