Cellular signaling systems regulated by oxidative stress and ROS-sensitive phosphatases

2013 Fiscal Year Final Research Report

• Project Area: Signaling functions of reactive oxygen species
• Project/Area Number: 20117012
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Hiroshima University
• Principal Investigator: KAMATA HIDEAKI 広島大学, 大学院医歯薬保健学研究院, 准教授 (10233925)
• Co-Investigator(Kenkyū-buntansha): ASANO Tomoichiro 広島大学, 大学院医歯薬保健学研究院, 教授 (70242063) ; NAKATSU Yusuke 広島大学, 大学院医歯薬保健学研究院, 助教 (20452584) ; YOEDA Masayasu 広島大学, 大学院医歯薬保健学研究院, 助教 (30508130)
• Project Period (FY): 2008-11-13 – 2013-03-31
• Keywords: 酸化ストレス / NF-kB / 活性酸素種 / ユビキチン / 紫外線 / IKKb / p38 / CK2

Research Abstract

Cross-talk between reactive oxygen species (ROS) and cellular signaling systems, including NF-kB pathway, plays an important role in inflammation and cell death. IKKb phosphorylates IkB and activates NF-kB when cells are treated with proinflammatory cytokines. We found that the nuclear IKKb acts as an adaptor protein for IkBa ubiquitination and degradation for oxidative stress-induced NF-kB activation. NF-kB activation by the nuclear IKKb suppresses anti-apoptotic gene expression and promotes cell death. NF-kB-mediated suppression of anti-apoptotic genes is involved in acetaminophen-induced liver injury in mice. ROS promote extracellular secretion of RIP3 and then regulate necroptosis.

Research Products

• [Journal Article] Lactobacillus casei strain Shirota protects against non-alcoholic steatohepatitis development in a rodent model (2013)
  • Author(s): Hirofumi Okubo, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Yusuke Nakatsu, Toshiaki Fukushima, Yasuka Matsunaga, Hideaki Kamata, Takashi Asahara, Yasuto Yoshida, Osamu Chonan, Misaki Iwashita, Fusanori Nishimura Tomoichiro Asano
  • Journal Title: American Journal Physiolgy-Gastrointestinal Liver Physiogy Volume: 305 Pages: 911-918
  • Peer Reviewed
• [Journal Article] Valsartan restores inflammatory response by macrophages in adipose hepatic tissues of LPS-infused mice (2013)
  • Author(s): Misaki Iwashita, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Toshiaki Fukushima,Sonoko Kumamoto, Takanori Shinjo, Hideaki Kamata, Fusanori Nishimura Tomoichiro Asano
  • Journal Title: Adipocyte Volume: 2 Pages: 28-32
  • Peer Reviewed
• [Journal Article] Resistin-Like Moleculeβ Is Abundantly Expressed in Foam Cells Is Involved in Atherosclerosis Development (2013)
  • Author(s): Akifumi Kushiyama, Hideyuki Sakoda, Naohide Oue, Masamichi Okubo, Yusuke Nakatsu, Haruya Ono, Toshiaki Fukushima, Hideaki Kamata, Fusanori Nishimura, Takako Kikuchi, Midori Fujishiro, Koichi Nishiyama, Hiroyuki Aburatani, Sakura Kushiyama, Masaki Iizuka, Naoyuki Taki, Jeffrey Encinas, Kazuhiro Sentani, Narumi Ogonuki, Atsuo Ogura, Shoji Kawazu, Wataru Yasui, Yukihito Higashi, Hiroki Kurihara, Hideki Katagiri, Tomoichiro Asano
  • Journal Title: Arteriosclerosis, Thrombosis, Vascular Biology Volume: 33 Pages: 1986-1993
  • Peer Reviewed
• [Journal Article] Par14 associates with IRS-1, thereby enhancing insulin-induced IRS-1 phosphorylation metabolic actions (2013)
  • Author(s): Jun Zhang, Yusuke Nakatsu, Takanori Sinjo, Ying Guo, Hideyuki Sakoda, Takeshi Yamamotoya, Yuichiro Otani, Hirofumi Okubo, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yoshihiro Tsuchiya, Hideaki Kamata, Fusanori Tsuchiya, Hideaki Kamata, Fusanori Nishimura, Hideki Katagiri, Shin-ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano
  • Journal Title: Journal of Biological Chemistry Volume: 288 Pages: 20692-20701
  • Peer Reviewed
• [Journal Article] Integrator complex plays an essential role in adipose differentiation (2013)
  • Author(s): Yuichiro Otani, Yusuke Nakatsu, Hideyuki Sakoda, Toshiaki Fukushima, Midori Fujishiro, Akifumi Kushiyama, Hirofumi Okubo, Yoshihiro Tsuchiya, Haruya Ohno, Shin-Ichiro Takahashi, Fusanori Nishimura, Hideaki Kamata, Hideki Katagiri, Tomoichiro Asano
  • Journal Title: Biochemical Biophysical Research Communications Volume: 434 Pages: 197-202
  • Peer Reviewed
• [Journal Article] Promotion of DNA repair by nuclear IKKβ phosphorylation of ATM in response to genotoxic stimuli (2013)
  • Author(s): Kei Sakamoto, Yohko Hikiba, Hayato Nakagawa, Yoshihiro Hirata, Yoku Hayakawa, Hiroto Kinoshita, Wachiko Nakata, Kosuke Sakitani, Ryota Takahashi, Masao Akanuma, Hideaki Kamata, Shin Maeda
  • Journal Title: Oncogene Volume: 32 Pages: 1854-1862
  • Peer Reviewed
• [Journal Article] TNF-αによるリン酸化シグナルと酸化ストレスのクロストークと細胞死 (2013)
  • Author(s): 土谷佳弘, 鎌田英明
  • Journal Title: 医学の歩み Volume: Vol.247 Pages: 806-810
• [Journal Article] Role of Pin1 in the pathogenesis of non-alcoholic steatohepatitis in a rodent model (2012)
  • Author(s): Yusuke Nakatsu, Yuichiro Otani, Hideyuki Sakoda, Jun Zhang, Ying Guo, Hirofumi Okubo, Akifumi Kushiyama, Midori Fujishiro, Takako Kikuch, Toshiaki Fukushima, Haruya Ohno, Yoshihiro Tsuchiya, Hideaki Kamata, Akiko Nagamachi, Toshiya Inaba, Fusanori Nishimura, Hideki Katagiri, Shin-ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano
  • Journal Title: Journal of Biological Chemistry Volume: 287 Pages: 44526-44535
  • Peer Reviewed
• [Journal Article] Angiotensin receptor 1 blocker valsartan normalizes gene expression profiles of 3T3-L1 adipocytes altered by co-culture with LPS-treated RAW264.7 macrophages (2012)
  • Author(s): Sonoko Kumamoto, Akifumi Kushiyama, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Misaki Iwashita, Haruya Ohno, Jun Zhang, Ying Guo, Hiroyuki Aburatani, Hideaki Kamata, Fusanori Nishimura, Tomoichiro Asano
  • Journal Title: Obesity Research & Clinical Practice Volume: 6 Pages: 288-297
  • Peer Reviewed
• [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation improves insulin resistance in cocultured adipocytes (2012)
  • Author(s): Misaki Iwashita, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Haruya Ohno, Yusuke Nakatsu, Toshiaki Fukushima, Sonoko Kumamoto, Yoshihiro Tsuchiya, Takako Kikuchi, Hiroki Kurihara, Hiroshi Akazawa, Issei Komuro, Hideaki Kamata, Fusanori Nishimura, Tomoichiro Asano
  • Journal Title: American Journal of Physiology-Endocrinology Metabolism Volume: 302 Pages: 286-296
• [Journal Article] 活性酸素によるリン酸化シグナルの制御と炎症・発がん (2012)
  • Author(s): 鎌田英明
  • Journal Title: 実験医学増刊 Volume: Vol.30 Pages: 2786-2792
• [Journal Article] 発癌・神経細胞の生死に関わる細胞内ROS シグナル (2012)
  • Author(s): 鎌田英明,上原孝
  • Journal Title: 細胞工学(秀潤社) Volume: Vol.31 Pages: 165-170
• [Journal Article] Xanthine oxidoreductase is involved in macrophage foam cell formation atherosclerosis development (2011)
  • Author(s): Akifumi Kushiyama, Hirofumi Okubo, Hideyuki Sakoda, Takako Kikuchi, Midori Fujishiro, Hirokazu Sato, Sakura Kushiyama, Misaki Iwashita, Fusanori Nishimura, Toshiaki Fukushima, Yusuke Nakatsu, Hideaki Kamata, Shoji Kawazu, Yukihito Higashi, Hiroki Kurihara, Tomoichiro Asano
  • Journal Title: Arteriosclerosis, Thrombosis, Vascular Biology Volume: 32 Pages: 291-298
  • Peer Reviewed
• [Journal Article] On off system for PI3-kinase Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN) (2011)
  • Author(s): Naoki Numajiria, Kumi Takasawa, Tadashi Nishiy, Hirotaka Tanaka, Kazuki Ohno, Wataru Hayakawa, Mariko Asada, Hiromi Matsuda, Kaoru Azumi, Hideaki Kamata, Tomohiro Nakamura, Hideaki Hara, Masabumi Minami, Stuart A. Lipton, Takashi Uehara
  • Journal Title: Poceedings of the National Academy of Sciences of the United States of America Volume: 108 Pages: 10349-10354
• [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 enhances insulin actions adipogenesis (2011)
  • Author(s): Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Jun Zhang, Hiraku Ono, Midori Fujishiro, Takako Kikuchi, Toshiaki Fukushima, Masayasu Yoneda, Haruya Ohno, Nanao Horike, Machi Kanna, Yoshihiro Tsuchiya, Hideaki Kamata, Fusanori Nishimura, Toshiak Isobe, Takehide Ogihara, Hideki Katagiri, Yoshitomo Oka, Shin-ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 20812-20822
  • Peer Reviewed
• [Journal Article] 4F2hc stabilizes GLUT1 protein increases glucose transport activity (2011)
  • Author(s): Haruya Ohno, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Yuichiro Otani, Hirofumi Okubo, Masayasu Yoneda, Toshiaki Fukushima, Yoshihiro Tsuchiya, Hideaki Kamata, Fusanori Nishimura, Hiroki Kurihara, Hideki Katagiri, Yoshitomo Oka, Tomoichiro Asano
  • Journal Title: American Journal of Physiology ; Cell Physiology Volume: 300 Pages: 1047-1054
  • Peer Reviewed
• [Journal Article] IKKβ is an adaptor protein for β-TrCP mediated IкBα ubiquitination in UV-induced NF-кB activation (2010)
  • Author(s): Yoshihiro Tsuchiya, Tomoichiro Asano, Keiko Nakayama, Tomohisa Kato Jr., Michael Karin, Hideaki Kamata
  • Journal Title: Molecular Cell Volume: 39 Pages: 570-582
  • Peer Reviewed
• [Journal Article] IκBβ is a positive negative regulator of NF-κB activity during inflammation (2010)
  • Author(s): Hideaki Kamata, Yoshihiro Tsuchiya, Tomoichiro Asano
  • Journal Title: Cell Research Volume: 20 Pages: 1178-1180
  • Peer Reviewed
• [Journal Article] Pin1 associates with induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity (2010)
  • Author(s): Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Nanao Horike, Masayasu Yoneda, Haruya Ohno, Yoshihiro Tsuchiya, Hideaki Kamata, Hidetoshi Tahara, Toshiaki Isobe, Fusanori Nishimura, Hideki Katagiri, Yoshitomo Oka, Toshiaki Fukushima, Shin-Ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro AsanoYusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Hiraku Ono, Midori Fujishiro, Nanao Horike, Masayasu Yoneda, Haruya Ohno, Yoshihiro Tsuchiya, Hideaki Kamata, Hidetoshi Tahara, Toshiaki Isobe, Fusanori Nishimura, Hideki Katagiri, Yoshitomo Oka, Toshiaki Fukushima, Shin-Ichiro Takahashi, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano
  • Journal Title: Journal of Biological Chemistry Volume: 285 Pages: 33018-33027
  • Peer Reviewed
• [Journal Article] Decreased SIRT1 expression LKB1 phosphorylation occurs with long-term high-fat diet feeding, in addition to AMPK phosphorylation impairment in the early phase (2010)
  • Author(s): Masayasu Yoneda, Ying Guo, Haruya Ono, Yusuke Nakatsu, Jun Zhang, XingLong Cui, Misaki Iwashita, Sonoko Kumamoto, Yoshihiro Tsuchiya, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Yuko Koketsu, Takako Kikuchi, Hideaki Kamata, Fusanori Nishimura,Tomoichiro Asano
  • Journal Title: Obesity Research Clinical Practice Volume: 4 Pages: 201-207
  • Peer Reviewed
• [Journal Article] Macrophage foam cell formation is augmented in serum from patients with diabetic angiopathy (2010)
  • Author(s): Xinglong Cui, Akifumi Kushiyama, Masayasu Yoneda, Yusuke Nakatsu, Ying Guo, Jun Zhang, Haruya Ono, Machi Kanna, Hideyuki Sakoda, Hiraku Ono, Takako Kikuchi, Midori Fujishiro, Masashi Shiomi, Hideaki Kamata, Hiroki Kurihara, Masatoshi Kikuchi, Shoji Kawazu, Fusanori Nishimura, Tomoichiro Asano
  • Journal Title: Diabetes Research Clinical Practice Volume: 87 Pages: 57-63
  • Peer Reviewed
• [Journal Article] 活性酸素によるリン酸化シグナル制御 (2009)
  • Author(s): 鎌田英明
  • Journal Title: 実験医学増刊 Volume: Vol.27 Pages: 2366-2372
• [Presentation] 転写活性非依存性のRelA によるIKKβ活性制御機 (2013)
  • Author(s): 土谷佳弘, 金本麻裕, 浅野知一郎, 鎌田英明
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-05
• [Presentation] Nedd4-IRS2複合体の形成機構とこの複合体が前立腺がん細胞の過増殖に果たす役割 (2013)
  • Author(s): 福嶋俊明,吉原英人,古田遥佳,伯野史彦,千田和広,佐伯泰,田中啓二,伊藤昭博,田稔,中津祐介,鎌田英明,高橋伸一郎,浅野知一郎
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-05
• [Presentation] TNFに応答したRIP1/RIP3複合体形成における活性酸素種(ROS)の関与と細胞の生と死の制御 (2013)
  • Author(s): 金本麻裕, 土谷佳弘, 浅野知一郎, 鎌田英明
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] プロリン異性化酵素Pin1による新規AMPK 機能制御機構の解明 (2013)
  • Author(s): 中津祐介,岩下未咲,松永泰花,福嶋俊明,迫田秀之,櫛山 暁史,鎌田英明,内田隆史,高橋伸一郎,浅野知一郎
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] 非アルコール性脂肪肝炎発症におけるLUBAC の形成の解析 (2013)
  • Author(s): 松永泰花,中津祐介,福嶋俊明,大久保博史,迫田秀之,土谷 佳弘,鎌田英明,徳永文稔,岩井 一宏,浅野知一郎
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] ストレス応答による核内IKKβを介したNF-κB活性化と細胞死 (2013)
  • Author(s): 土谷佳弘, 金本麻裕, 浅野知一郎, 鎌田英明
  • Organizer: 第86回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-13
• [Presentation] 腫瘍壊死因子(TNF)に応答したネクロプトーシス誘導キナーゼRIP-3の細胞外分泌による細胞死の制御 (2013)
  • Author(s): 金本麻裕, 土谷佳弘, 浅野知一郎, 鎌田英明
  • Organizer: 第86回日本生化学会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2013-09-13
• [Presentation] IKKβの脱リン酸化反応における転写因子RelAの関与 (2012)
  • Author(s): 土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
  • Organizer: 第85回日本生化会合同大会ワークショップ
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] 腫瘍壊死因子(TNFα)に応答した細胞死とRIP1とRIP3の発現変化 (2012)
  • Author(s): 金本麻裕, 土谷佳弘, 浅野知一郎, 鎌田英明
  • Organizer: 第85回日本生化学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] TNFに連関したシグナル系のレドックス制御と細胞死 (2012)
  • Author(s): 鎌田英明
  • Organizer: 第85回日本生化学会合同大会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] Stress-induced NF-kB activation mediated by the nuclear IKK cell death (2012)
  • Author(s): 土谷佳弘, 金本麻裕, 菅野雅元, 浅野知一郎, 鎌田英明
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-13
• [Presentation] Nuclear IKKβ acts as an adaptor protein for IкBα ubiquitination degradation in UV-oxidative stress-induced NF-кB activation (2012)
  • Author(s): Yoshihiro Tsuchiya, Tomoichiro Asano, Keiko Nakayama, Tomohisa Kato, Jr., Michael Karin, Hideaki Kamata
  • Organizer: Keystone Symposium, " NF-kappaB Signaling Biology : From Bench to Bedside "
  • Place of Presentation: Whistler, British Columbia, Canada
  • Year and Date: 2012-03-25
• [Presentation] IKKβの多重的活性制御機構ー転写因子p65によるネガティブフィードバックとレドックス制御の関与 (2011)
  • Author(s): 土谷佳弘, 浅野知一郎, 菅野雅元,鎌田英明
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-16
• [Presentation] Nuclear IKKβ phosphrylates ATM in response to genotoxic stimuli, which promotes DNA repair. (2011)
  • Author(s): Kei Sakamoto, Yohko Hikiba, Yoshihiro Hirata, Masao Akanuma, Hideaki Kamata Shin Maeda
  • Organizer: 第34回日本分子生物学会年会ワークショップ
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-15
• [Presentation] 非アルコール性脂肪性肝炎発症における肝および血球系細胞のプロリン異性化酵素Pin1の役割 (2011)
  • Author(s): 中津祐介, 張君, 大久保博史, 福島俊明, 迫田秀之, 藤城緑, 櫛山暁史, 高橋伸一郎, 鎌田英明, 栗原裕基,内田隆史, 浅野知一郎
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] プロリン異性化酵素Par14とPin1のインスリンシグナルと糖・脂質代謝における役割 (2011)
  • Author(s): 浅野知一郎,中津祐介,山本屋武,藤城緑,櫛山暁史,郭瑩,張君,福嶋俊明,鎌田英明,栗原裕基, 内田隆史, 迫田秀之
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-12-14
• [Presentation] 非アルコール性脂肪性肝炎発症におけるプロリン異性化酵素Pin1の役割 (2011)
  • Author(s): 中津祐介, 張君, 大久保博史, 福嶋俊明, 迫田秀之, 櫛山暁史, 鎌田英明, 内田隆史, 浅野知一郎
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] 肝細胞においてNedd4はインスリン受容体基質(IRS)-2のユビキチン化を介してインスリンシグナルを増強する (2011)
  • Author(s): 福嶋俊明, 吉原英人, 伯野史彦, 佐伯泰, 田中啓二, 伊藤昭博, 中津祐介, 鎌田英明, 高橋伸一郎, 浅野知一郎
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Ubiquitin-like domain(ULD)内におけるL353A変異体を用いたIKKbetaタンパク質分解機構の解析 (2011)
  • Author(s): 金本麻裕, 土谷佳弘, 浅野知一郎, 鎌田英明
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] IKKβ act as an adaptor protein for IκBα ubiquitination degradation in UV-induced NF-κB activation ; possible involvement in the TNF signaling (2011)
  • Author(s): Yoshihiro Tsuchiya Hideaki Kamata
  • Organizer: 13th International TNF Conference
  • Place of Presentation: Awajishima, Japan
  • Year and Date: 2011-05-17
• [Presentation] 肥満、脂肪肝およびNASH発症におけるプロリンイソメラーゼPin1の関与 (2011)
  • Author(s): 中津祐介, 張君, 福島俊明, 迫田秀之, 櫛山暁史, 藤城緑, 大野晴也, 大久保博史, 大谷裕一郎, 福島俊明, 鎌田英明, 内田隆史, 浅野知一郎
  • Organizer: 第52回日本生化学会中国四国支部会
  • Place of Presentation: 広島
  • Year and Date: 2011-05-14
• [Presentation] Nedd4によるインスリン受容体基質(IRS)のユビキチン化はインスリン・IGF-Iシグナルを増強する (2011)
  • Author(s): 福島俊明, 吉原英人, 伯野史彦, 佐伯泰, 田中啓二, 伊藤昭博, 中津祐介, 鎌田英明, 高橋伸一郎, 浅野知一郎
  • Organizer: 第52回日本生化学会中国四国支部会
  • Place of Presentation: 広島
  • Year and Date: 2011-05-14
• [Presentation] 「エネルギー状態によるCRTC3の発現制御と脂肪分化における役割の解明 (2010)
  • Author(s): 中津祐介, 迫田秀之, 櫛山暁史, 張君, 福嶋俊明, 内田隆史, 鎌田英明, 浅野知一郎
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] 新規Pin1結合タンパク質Trk-fused geneはAktの活性化を促進する (2010)
  • Author(s): 大崎慶子, 中津祐介, 迫田秀之, 櫛山暁史, 大野晴也, 渡辺俊明, 内田隆史, 福嶋俊明, 鎌田英明, 浅野知一郎
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] NF-κBと活性酸素(ROS)シグナルに連関したタンパク質のリン酸化と分解による細胞応答 (2010)
  • Author(s): 鎌田英明, 土谷佳弘, 浅野知一郎
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] 細胞内ストレスに応答した核内IKK?を介した新規NFкB活性化機構 (2010)
  • Author(s): 土谷佳弘, 浅野知一郎, 鎌田英明
  • Organizer: 第33回日本分子生物学会・第83回日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Nuclear IKKβ acts as an adaptor protein for IкBα degradation in UV-induced NF-кB activation (2010)
  • Author(s): 鎌田英明, 土谷佳弘
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Peptidyl prolyl cis/trans isomerase Pin1 interacts with CRTC2 regulates gluconeogenesis (2010)
  • Author(s): Yusuke Nakatsu, Nanao Horike, Akifumi Kushiyama, Hideyuki Sakoda, Haruya Ohno, Machi Kanna, Hideaki Kamata, Hiroki Kurihara, Takafumi Uchida, Tomoichiro Asano
  • Organizer: 70th Americiabetes Association
  • Place of Presentation: Orlo, Florida, USA
  • Year and Date: 2010-06-27
• [Presentation] Nuclear IKKβ acts as an adaptor protein for IкBα degradation in UV-induced NF-кB activation promotes cell death (2010)
  • Author(s): Hideaki Kamata
  • Organizer: International Symposium on the Innovation for Health Sustainable Life
  • Place of Presentation: Hiroshima University, Japan
  • Year and Date: 2010-03-09
• [Presentation] 核内IKKを介したNF-кB活性化による細胞死亢進 (2009)
  • Author(s): 土谷佳弘, 浅野知一郎, 中山啓子, 加藤友久, Michael Karin, 鎌田英明
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] 細胞内ストレスに応答した核内IKKβ を介した新規NF-кB活性化機構 (2009)
  • Author(s): 土谷佳弘, 浅野知一郎, 中山啓子, 加藤友久, Michael Karin, 鎌田英明
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Pin1 Binds to IRS-1, Functions as a Nutrient-Sensing Enhancer of Insulin Signaling (2009)
  • Author(s): Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Masayasu Yoneda, Haruya Ohno, Hideaki Kamata, Takafumi Uchida, Tomoichiro Asano
  • Organizer: 69th Americiabetes Association
  • Place of Presentation: New Orleans, Louisiana, USA
  • Year and Date: 2009-06-08