2012 Fiscal Year Final Research Report
EVALUATION OF BIOLOGICAL EFFECTS OF AEROSOL
| Project Area | Impacts of aerosols in East Asia on plants and human health |
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| Project/Area Number |
20120014
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Kyoto University (2011-2012)
National Institute for Environmental Studies (2008-2010) |
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Principal Investigator |
TAKANO Hirohisa 京都大学, 大学院・工学研究科, 教授 (60281698)
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| Co-Investigator(Kenkyū-buntansha) |
KOIKE Eiko 独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (60353538)
YANAGISAWA Rie 独立行政法人国立環境研究所, 環境健康研究センター, 主任研究員 (70391167)
INOUE Kenichirou 国際医療福祉大学, 保健医療学部, 教授 (20373219)
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| Project Period (FY) |
2008 – 2012
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| Keywords | 微小粒子 / 生体影響 / 免疫影響 / 呼吸器影響 / メカニズム |
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| Research Abstract |
The present study investigated the effects of chemicals such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, which are major chemical components in particulate matter (PM), on the immune cells and on the bronchial epithelial cells. First, we detected some biomarkers for the health effects of PM. Cytotoxicity and/or inflammatory responses were induced by some PAH derivatives containing hydroxyl, carbonyl, nitro, or amino groups, indicating that the toxicological and inflammatory effects of chemicals may be related to their structures such as functional group and isomer. We also elucidated the underlying molecular mechanisms for the health effects of these chemicals.
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