2022 Fiscal Year Final Research Report
Properties and Functions of Deuterated Materials
| Project Area | Deuterium Science |
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| Project/Area Number |
20H05740
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (II)
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| Research Institution | Kyoto University |
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Principal Investigator |
Naka Hiroshi 京都大学, 薬学研究科, 准教授 (70431517)
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| Co-Investigator(Kenkyū-buntansha) |
金尾 英佑 京都大学, 薬学研究科, 助教 (40895166)
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| Project Period (FY) |
2020-10-02 – 2023-03-31
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| Keywords | 重水素 / 重水素化 / 医薬分子 / 分子触媒 / 重水素学 / 重水素化触媒 / 重水素化医薬品 / 重医薬品 |
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| Outline of Final Research Achievements |
Understanding of the properties of deuterated materials is of particular significance in deuterium science. We achieved the synthesis of site-specifically deuterated molecules and the evaluation of their properties. Iridium-catalyzed alpha-selective deuteration of alcohols was developed and allowed chemoselective deuteration of pharmaceuticals including losartan potassium. Also, site-selectively deuterated simplified Maruoka catalysts was synthesized. The deuterated catalyst showed higher stability under reaction conditions over non-deuterated analogs. These results showed that site-selective deuteration of pharmaceuticals and molecular catalysts is an effective strategy for improving material properties.
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| Free Research Field |
有機化学，触媒化学，合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
重水素化物質の合成法開発、理論構築、機能開拓、代謝研究への利用からなる「重水素学」の構築は、重水素が関わる科学分野の発展に絶大な影響を与える。その中でも機能開拓は、今後の重水素化物質の合成指針を決める重要な役割を担う。本研究では、医薬分子や分子触媒の位置選択的な重水素化が、その機能向上につながることを明らかにした。これは重水素化物質の有用性を示す重要な研究結果であり、今後の医薬・物理・化学・生命科学の進歩に対する貢献が期待できる。
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