2022 Fiscal Year Final Research Report
Molecular mechanisms for thermosensation in hibernation: clarification of the significance of thermosensitive TRP channels
| Project Area | Mammalian hibernation biology ~ survival strategies via hypometabolism and hypothermia |
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| Project/Area Number |
20H05768
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (III)
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| Research Institution | Center for Novel Science Initatives, National Institutes of Natural Sciences |
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Principal Investigator |
TOMINAGA Makoto 大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 教授 (90260041)
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| Project Period (FY) |
2020-10-02 – 2023-03-31
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| Keywords | 冬眠 / 休眠 / 温度受容 / 温度感受性TRPチャネル / 視床下部神経 |
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| Outline of Final Research Achievements |
We analyzed heat-evoked current responses of TRPA1 from various species (hamster, rat, mouse, human, squirrel) with a patch-clamp method. All the TRPA1s were activated by heat stimulus although only hamster and rat TRPA1s were occasionally activated by cold stimulus. Mouse TRPA1 was not cold sensitive. Hamster TRPA1 showed largest heat-evoked currents. Apparent temperature thresholds for heat-evoked activation of TRPA1s were in around our body temperature range. While an initial report showed rodent TRPA1 is activated by noxious cold stimulus, it is now clear that TRPA1s have an ability to detect heat stimulus. Heat sensitivity of TRPA1 might be involved in body temperature regulation especially in hibernating animals.
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| Free Research Field |
分子細胞生理学
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| Academic Significance and Societal Importance of the Research Achievements |
体温近傍の熱刺激による大きなTRPA1電流が観察されたことは、TRPA1が体温調節に関わっていることを示唆する。温度感受性TRPチャネルが脳で体温制御に関わっていることの初めての発見である。脳、特に視床下部でどのような入力情報から体温制御がなされているかは未だ明らかでなく、学術的意義は大きい。また、温度感受性TRPチャネル、特にTRPA1の機能制御によって体温制御が可能なことを意味し、体温制御の新しい方法としての社会的意義も大きい。このTRPA1を介した体温制御は、冬眠における積極的体温低下に関わる可能性がある。
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