The general importance of lysosomal exocytosis in acid adaptation

2023 Fiscal Year Final Research Report

• Project Area: Establishment of pH Biology
• Project/Area Number: 20H05789
• Research Category: Grant-in-Aid for Transformative Research Areas (B)
• Allocation Type: Single-year Grants
• Review Section: Transformative Research Areas, Section (III)
• Research Institution: Kyoto University (2022-2023); Osaka University (2020-2021)
• Principal Investigator: Funato Yosuke 京都大学, 工学研究科, 准教授 (60505775)
• Project Period (FY): 2020-10-02 – 2023-03-31
• Keywords: 酸性環境適応 / lysosomal exocytosis / PRL / リソソーム

Outline of Final Research Achievements

We found that increased PRL3 expression under acidic conditions is important for the induction of lysosomal exocytosis, and that the overexpression of PRL3 in malignant cancer cells is part of the physiological adaptation to the acidic environment. In addition, from chemical screening using compounds with known targets we also revealed the importance of signaling pathways that are activated in malignant cancer tissues.

Free Research Field

医化学関連

Academic Significance and Societal Importance of the Research Achievements

本研究によりlysosomal exocytosisの普遍的重要性を明らかにでき、酸性環境適応の理解が大きく進んだと考えられる。今後さらに多様な生物種においても同様の仕組みで酸性環境適応が行われているかなど、研究を展開させてゆくことで地球上の生命に共通した、さらに「普遍的」な重要性についても明らかにしてゆけると期待される。