計算解剖モデルの構築

2011 Fiscal Year Annual Research Report

• Project Area: Computational anatomy for computer-aided diagnosis and therapy :Frontiers of medical image sciences
• Project/Area Number: 21103004
• Research Institution: Gifu University
• Principal Investigator: 藤田 廣志 岐阜大学, 医学系研究科, 教授 (10124033)
• Co-Investigator(Kenkyū-buntansha): 原 武史 岐阜大学, 医学系研究科, 准教授 (10283285) ; 周 向栄 岐阜大学, 医学系研究科, 助教 (00359738)
• Keywords: 解剖学 / 画像支援診断 / 臓器モデル / 画像認識 / 臓器抽出 / CT画像 / FDG-PET画像

Research Abstract

平成23年度の研究成果は,主に以下の四つである.
(1)臓器の自動抽出の汎用手順の構築
・ 異なる臓器領域の自動抽出問題を一つの汎用処理手順で解決するアプローチの提案.
・ 大規模なCT画像データベースに基づく機械学習,類似画像検索などの新しい技術の導入.
・ CT画像から心臓,肝臓,左右腎臓,脾臓の自動抽出実験の実施と抽出手順の性能評価.
(2)臓器の形状モデルの構築
・ MDL法による臓器の確率的形状モデルの構築法の開発
・ CT画像を用いた心臓,肝臓,左右腎臓,脾臓の確率的形状モデルの構築
・ 形状モデルに基づく筋肉領域の自動抽出法の提案と改善
(3)FDG-PET画像に基づく人体の代謝モデルの構築
・ 全身範囲における画素単位での代謝量の統計的分析
・ 人体の正常代謝モデルの構築
・正常代謝モデルに基づく異常候補の自動検出法の開発
(4)歯科のパノラマX線写真と眼底写真における計算機支援診断(CAD)システムの開発
・ 歯科のパノラマX線写真に基づく下顎皮質骨抽出のモデル構築
・ 眼底写真における緑内障のCADシステムの開発
以上の成果によって,計算解剖学に関する研究の将来像を具体的に示したと考える.また,関連している技術の有効性も検証できた.本研究の応用対象として,救急現場のCADシステムおよび脳MRI画像のCADシステムに対して,出血および異常部位の検出などの成果を得た.

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

計画書の通りに研究が進み,特に大きな問題がなく,予定通りに成果が得られた.

Strategy for Future Research Activity

研究計画に従って,研究を推進する予定である.日本国内での研究協力を積極的に推進するとともに,海外でも出来るだけ活発な研究活動と交流を行うことを考えている.

Research Products

• [Journal Article] Automatic localization of solid organs on 3D CT images by a collaborative majority voting decision based on ensemble learning (2012)
  • Author(s): X.Zhou, T.Hara, H.Fujita, et al.
  • Journal Title: Computerized Medical Imaging and Graphics Volume: 36 Pages: 304-313
  • DOI: 10.1016/j.compmedimag.2011.12.004
  • Peer Reviewed
• [Journal Article] Automatic organ segmentation on torso CT images by using content-based image retrieval (2012)
  • Author(s): X.Zhou, T.Hara, H.Fujita, et al.
  • Journal Title: Proc. of SPIE Medical Imaging Volume: 8314 Pages: 83143E1-7
  • DOI: 10.1117/12.912359
  • Peer Reviewed
• [Journal Article] Computerized detection of lung nodules by CT for radiologic technologists in preliminary screening (2012)
  • Author(s): Y.Lee, D.-Y.Tsai, H.Hokari, Y.Minagawa, M.Tsurumaki, T.Hara, H.Fujita
  • Journal Title: Radiological Physics and Technology Volume: 5(in press)
  • DOI: 10.1007/s12194-012-0145-6
  • Peer Reviewed
• [Journal Article] Computer-aided diagnosis for detection of lacunar infarcts on MR images : ROC analysis of radioloists' prformance (2012)
  • Author(s): Y.Uchiyama, T.Asano, H.Kato, T.Hara, M.Kanematsu, H.Hoshi, T.Iwama, H.Fujita
  • Journal Title: Journal of Digital Imaging Volume: (in press)
  • DOI: 10.1007/s10278-011-9444-4
  • Peer Reviewed
• [Journal Article] Automated segmentation of psoas major muscle in X-ray CT images by use of a shape model : Preliminary study (2012)
  • Author(s): N.Kamiya, X.Zhou, H.Chen, C.Muramatsu, T.Hara, R.Yokoyama, M.Kanematsu, H.Hoshi, H.Fujita
  • Journal Title: Radiological Physics and Technology Volume: 5 Pages: 5-14
  • DOI: 10.1007/s12194-011-0127-0
  • Peer Reviewed
• [Journal Article] Staging hepatic fibrosis : Computer-aided analysis of hepatic contours on Gd-EOB-DTPA-enhanced hepatocyte-phase MR images (2012)
  • Author(s): S.Goshima, M.Kanematsu, T.Kobayashi, T.Furukawa, X.Zhang, H.Fujita, H.Watanabe, H.Kondo, N.Moriyama, K.T.Bae
  • Journal Title: Hepatology Volume: 55 Pages: 328-329
  • DOI: 10.1002/hep.24677
  • Peer Reviewed
• [Journal Article] Automated scheme for measuring mandibular cortical thickness on dental panoramic radiographs for osteoporosis screening (2012)
  • Author(s): T.Matsumoto, T.Hayashi, T.Hara, A.Katsumata, C.Muramatsu, X.Zhou, Y.Iida, M.Matsuoka, K.Katagi, H.Fujita
  • Journal Title: Proc.of SPIE medical imaging Volume: 8315 Pages: 83152L
  • DOI: 10.1117/12.912309
• [Journal Article] An application of the texton learning model via sparse representation on pulmonary emphysema classification (2012)
  • Author(s): M.Zhang, X.Zhou, H.Chen, C.Muramatsu, T.Hara, R.Yokoyama, M.Kanematsu, H.Fujita
  • Journal Title: Proc.of SPIE medical imaging Volume: 8315 Pages: 831534
  • DOI: 10.1117/12.912454
• [Journal Article] Pulmonary nodule detection in PET/CT images : Improved approach using combined nodule detection and hybrid FP reduction (2012)
  • Author(s): A.Teramoto, H.Fujita, Y.Tomita, K.Takahashi, O.Yamamuro, T.Tamaki
  • Journal Title: Proc.of SPIE medical imaging Volume: 8315 Pages: 83152V
  • DOI: 10.1117/12.912102
• [Journal Article] A fast and fully automatic method for cerebrovascular segmentation on time-of-flight (TOF) MRA image (2011)
  • Author(s): X.Gao, Y.Uchiyama, X.Zhou, T.Hara, T.Asano, H.Fujita
  • Journal Title: Journal of Digital Imaging Volume: 24 Pages: 609-625
  • DOI: 10.1007/s10278-010-9326-1
  • Peer Reviewed
• [Journal Article] Automated selection of major arteries and veins for measurement of arteriolar-to-venular diameter ratio on retinal fundus images (2011)
  • Author(s): C.Muramatsu, Y.Hatanaka, T.Iwase, T.Hara, H.Fujita
  • Journal Title: Computerized Medical Imaging and Graphics Volume: 35 Pages: 472-480
  • DOI: 10.1016/j.compmedimag.2011.03.002
  • Peer Reviewed
• [Journal Article] Automated determination of cup-to-disc ratio for classification of glaucomatous and normal eyes on stereo retinal fundus images (2011)
  • Author(s): C.Muramatsu, T.Nakagawa, A.Sawada, Y.Hatanaka, T.Yamamoto, H.Fujita
  • Journal Title: Journal of Biomedical Optics Volume: 16 Pages: 096009-1-096009-7
  • DOI: 10.1117/1.3622755
  • Peer Reviewed
• [Journal Article] Automated segmentation of recuts abdominis muscle using shape model in X-ray CT images (2011)
  • Author(s): N.Kamiya, X.Zhou, H.Chen, C.Muramatsu, T.Hara, R.Yokoyama, M.Kanematsu, H.Hoshi, H.Fujita
  • Journal Title: Proc.of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume: 1 Pages: 7993-7996
  • DOI: 10.1109/IEMBS.2011.6091971
  • Peer Reviewed
• [Journal Article] Automatic measurement of cup to disc ratio based on line profile analysis in retinal images (2011)
  • Author(s): Y.Hatanaka, A.Noudo, C.Muramatsu, A.Sawada, T.Hara, T.Yamamoto, H.Fujita
  • Journal Title: Proc.of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume: 1 Pages: 3387-3390
  • DOI: 10.1109/IEMBS.2011.6090917
  • Peer Reviewed
• [Journal Article] Computerized detection of peripapillary chorioretinal atrophy by texture analysis (2011)
  • Author(s): C.Muramatsu, Y.Hatanaka, A.Sawada, T.Yamamoto, H.Fujita
  • Journal Title: Proc.of the 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume: 1 Pages: 5947-5950
  • DOI: 10.1109/IEMBS.2011.6091470
  • Peer Reviewed
• [Presentation] Improvement of MDL method by adaptive sampling on spherical parameter space (2012)
  • Author(s): R.Xu, X.Zhou, Y.Hirano, R.Tachibana, S.Kido, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Construction of the statistical shape models and its performance evaluation for the 3D torso organs using the MDL method (2012)
  • Author(s): S.Yamaguchi, X.Zhou, R.Xu, T.Hara, R.Yokoyama, M.Kanematsu, H.Hoshi, S.Kido, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Probabilistic atlas construction and performance evaluation of multiple organs in X-ray torso CT Images (2012)
  • Author(s): J.Sawada, T.Hayashi, X.Zhou, H.Chen, T.Hara, H.Jiang, R.Yokoyama, M.Kanematsu, H.Hoshi, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Automatic organs segmentation from non-contrast CT images by using content-based image retrieval (2012)
  • Author(s): A.Watanabe, X.Zhou, H.Chen, T.Hara, R.Yokoyama, M.Kanematsu, H.Hoshi, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Analysis of temporal changes and anatomical Standardized Uptake Value model on torso FDG-PET scans (2012)
  • Author(s): T.Suzuki, Y.Shimizu, T.Hara, T.Kobayashi, X.Zhou, S.Ito, T.Katafuchi, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Evaluation of anatomical registration method for torso FDG-PET scans (2012)
  • Author(s): Y.Shimizu, T.Suzuki, T.Kobayashi, T.Hara, X.Zhou, S.Itoh, S.Kumita, K.Ishihara, T.Katafuchi, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Osteoporosis screening by use of automated scheme for measuring mandibular cortical thickness on dental panoramic radiographs (2012)
  • Author(s): T.Matsumoto, T.Hayashi, T.Hara, A.Katsumata, C.Muramatsu, X.Zhou, Y.Iida, M.Matsuoka, K.Katagi, E.Ariji, S.Mori, T.Kaneda, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Development of automated analysis for early signs of cerebral infarctions on head X-ray CT images in emergency medical care (2012)
  • Author(s): K.Oshima, T.Hara, X.Zhou, K.Sakashita, C.Muramatsu, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Development of image analysis and quantitative evaluation of the Locomotive syndrome (2012)
  • Author(s): H.Nawa, T.Watanabe, D.Fukuoka, N.Teranayashi, T.Hara, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Glaucoma risk estimation based on automated measurement of cup-to-discratio and rim-to-disc ratio on retinal fundus images (2012)
  • Author(s): A.Noudo, Y.Hatanaka, C.Muramatsu, A.Sawada, T.Hara, T.Yamamoto, H.Fujita
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Computerized extraction of vessel regions in retinal fundus images : Performance evaluation using DRIVE Database (2012)
  • Author(s): S.Uruma, Y.Uchiyama, P.Zdenek, Y.Hatanaka, C.Muramatsu, T.Hara, H.Fujita, J.Shiraishi
  • Organizer: メディカルイメージング連合フォーラム
  • Place of Presentation: 沖縄
  • Year and Date: 20120119-20120120
• [Presentation] Automated scheme for measuring mandibular cortical thickness on dental panoramic radiographs for osteoporosis screening (2012)
  • Author(s): T.Matsumoto, T.Hayashi, T.Hara, A.Katsumata, C.Muramatsu, X.Zhou, Y.Iida, M.Matsuoka, K.Katagi, H.Fujita
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-07
• [Presentation] An application of the texton learning model via sparse representation on pulmonary emphysema classification (2012)
  • Author(s): M.Zhang, X.Zhou, H.Chen, C.Muramatsu, T.Hara, R.Yokoyama, M.Kanematsu, H.Fujita
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-07
• [Presentation] A new screening pathway for identifying asymptomatic patients using dental panoramic radiographs (2012)
  • Author(s): T.Hayashi, T.Matsumoto, T.Sawagashira, M.Tagami, A.Katsumata, Y.Hayashi, C.Muramatsu, X.Zhou, H.Fujita
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-07
• [Presentation] User-friendly tools on hand-held devices for observer performance study (2012)
  • Author(s): T.Matsumoto, T.Hara, J.Shiraishi, H.Abe, X.Zhou, H.Fujita
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-07
• [Presentation] Pulmonary nodule detection in PET/CT images : Improved approach using combined nodule detection and hybrid FP reduction (2012)
  • Author(s): A.Teramoto, H.Fujita, Y.Tomita, K.Takahashi, O.Yamamuro, T.Tamaki
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-07
• [Presentation] Automatic organ segmentation on torso CT images by using content-based image retrieval (2012)
  • Author(s): X.Zhou, A.Watanabe, X.Zhou, T.Hara, R.Yokoyam, M.Kanematsu, H.Fujita
  • Organizer: SPIE medical imaging
  • Place of Presentation: San Diego, USA
  • Year and Date: 2012-02-06
• [Presentation] State-of-the-art of computer-aided diagnosis (CAD) for medical images (2012)
  • Author(s): H.Fujita
  • Organizer: The 2012 International Workshop on Advanced Image Technology
  • Place of Presentation: Ho Chi Minh City, Vietnam(招待講演)
  • Year and Date: 2012-01-09
• [Presentation] Automated segmentation of recuts abdominis muscle using shape model in X-ray CT images (2011)
  • Author(s): N.Kamiya, X.Zhou, H.Chen, C.Muramatsu, T.Hara, R.Yokoyama, M.Kanematsu, H.Hoshi, H.Fujita
  • Organizer: The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Boston, USA
  • Year and Date: 20110830-20110903
• [Presentation] Automatic measurement of cup to disc ratio based on line profile analysis in retinal images (2011)
  • Author(s): Y.Hatanaka, A.Noudo, C.Muramatsu, A.Sawada,T.Hara, T.Yamamoto, H.Fujita
  • Organizer: The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Boston, USA
  • Year and Date: 20110830-20110903
• [Presentation] Computerized detection of peripapillary chorioretinal atrophy by texture analysis (2011)
  • Author(s): C.Muramatsu, Y.Hatanaka, A.Sawada, T.Yamamoto, H.Fujita
  • Organizer: The 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Place of Presentation: Boston, USA
  • Year and Date: 20110830-20110903
• [Presentation] Development of computer-aided classification system on mammograms and study on method of presenting CAD output (2011)
  • Author(s): T.Matsubara, T.Hara, N.Shinohara, T.Morita, T.Niwa, T.Endo, H.Fujita
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-12
• [Presentation] Automatic method for measuring mandibular cortical thickness by using active contour model on dental panoramic radiographs (2011)
  • Author(s): T.Matsumto, T.Hayashi, T.hara, A.Katsumata, C.Muramatsu, X.Zhou, Y.Iida, M.Matsuoka, K.Katagi, E.Ariji, S.Mori, T.Kaneda, H.Fujita
  • Organizer: 電子情報通信学会医用画像研究会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-12
• [Book] Detection of Cerebrovascular Diseasess (Chapter 17), in Computer-aided Detection and Diagnosis in Medical Imaging (2012)
  • Author(s): Y.Uchiyama, H.Fujita
  • Publisher: Taylor & Francis Books, Inc, USA(in press)
• [Book] Detection of Eye Diseases (Chapter 19), in Computer-aided Detection and Diagnosis in Medical Imaging (2012)
  • Author(s): C.Muramatsu, H.Fujita
  • Publisher: Taylor & Francis Books, Inc, USA(in press)
• [Book] Automatic organ localization on X-ray CT images by using ensemble learning techniques (Chapter 19), in Machine learning in computer-aided diagnosis : Medical imaging intelligence and analysis (2012)
  • Author(s): X.Zhou, H.Fujita
  • Total Pages: 403-418
  • Publisher: IGI Global, USA
• [Book] Sophisticated imaging technology in the assessment of osteoporosis risk (Chapter 10), in Osteoporosis (2012)
  • Author(s): H.Chen, K.Kubo, M.Onozuka, T.Hayashi, X.Zhou, H.Fujita
  • Total Pages: 181-194
  • Publisher: Intech Open Access Publisher
• [Book] Concept and practice of genetic algorithm template matching (GATM) and higher order local autocorrelation schemes in automated detection of lung nodules (Chapter 12), in Lung Imaging and Computer-Aided Diagnosis (2011)
  • Author(s): Y.Lee, T.Hara, D.Y.Tsai, H.Fujita
  • Total Pages: 267-295
  • Publisher: CRC Press, USA
• [Remarks]
  • URL: htpp://www.fit.info.gifu-u.ac.jp