Computer-Aided Diagnosis Based on Computational Anatomical Models

2013 Fiscal Year Final Research Report

• Project Area: Computational anatomy for computer-aided diagnosis and therapy :Frontiers of medical image sciences
• Project/Area Number: 21103005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: The University of Tokushima
• Principal Investigator: NIKI Noboru 徳島大学, ソシオテクノサイエンス研究部, 教授 (80116847)
• Co-Investigator(Kenkyū-buntansha): KAWATA Yoshiki 徳島大学, 大学院ソシオテクノサイエンス研究部, 准教授 (70274264) ; SUZUKI Hidenobu 徳島大学, 大学院ソシオテクノサイエンス研究部, 助教 (50546710) ; SHIMADA Mitsuo 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10216070) ; HARADA Masafumi 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (20228654) ; UENO Junji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (60116788) ; OHTSUKA Hideki 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (30346605) ; TAKAYAMA Tetsuji 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10284994) ; ABE Masahiro 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 (80263812) ; ITO Harumi 福井大学, 医学部, 特命教授 (40026943) ; EGUCHI Kenji 帝京大学, 医学部, 教授 (30349336) ; IINUMA Gen 国立がん研究センター, 中央病院, 医長 (60222824) ; KUSUMOTO Masahiko 国立がん研究センター, 中央病院, 副科長 (90252767) ; TSUCHIDA Takaaki 国立がん研究センター, 中央病院, 医長 (80256239) ; OHMATSU Hironobu 国立がん研究センター, 東病院, 副科長 (40415518) ; TAKAHASHI Masashi 滋賀医科大学, 医学部, 准教授 (20179526) ; NAKANO Yasutaka 滋賀医科大学, 医学部, 講師 (00362377) ; SAKAI Hiroaki 京都大学, 医学研究科, 非常勤講師 (50362489) ; TAKIGUCHI Yuuichi 千葉大学, 大学院医学研究院, 教授 (30272321) ; OHNO Yoshiharu 神戸大学, 医学研究科, 特命教授 (30324924)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Keywords: 計算解剖学 / コンピュータ支援診断システム / がん（肺がん、肝がん、大腸がん） / 慢性閉塞疾患(COPD) / 心血管・リンパ節疾患 / 骨粗鬆症

Research Abstract

The purpose of this research project is to develop computer-aided diagnosis (CAD) systems that enables very early detection and treatment for cancers and lifestyle-related diseases by using multimodal images. The goal of the research and development in this project was to reach a level of which the effectiveness of new CAD technologies can be reasonably proven and clinically tested for ensuring that practical application can be carried out. At the same time, this project contributes to construct fundamentals of computational anatomy research area through the organically-combined research progress with A01 group which performs fundamental research of computational anatomical models and A03 group which aims at clinical development of the computational anatomy. We have constructed the database integrated multimodality images with diagnostic results and developed clinical CAD systems that meet the needs of clinical practice.

Research Products

• [Journal Article] Evaluation of a near-infrared-type contrast medium extravasation detection system using a swine model (2014)
  • Author(s): T.Ishihara, T.Kobayashi, N.Ikeno, T.Hayashi, M.Sakakibara, N.Niki, M.Satake, N.Moriyama
  • Journal Title: J Comput Assist Tomogr Volume: Vol.38, No.2 Pages: .285-292
  • DOI: 10.1097/RCT.0000000000000013.
  • Peer Reviewed
• [Journal Article] Blood vessel-based liver segmentation using the portal phase of an abdominal CT dataset (2013)
  • Author(s): A.S.Maklad, M.Matsuhiro, H.Suzuki, Y.Kawata, N.Niki, M.Satake, N.Moriyama, T.Utsunomiya, M.Shimada
  • Journal Title: Medical Physics Volume: Vol.40, No.11 Pages: 113501(17)
  • DOI: 10.1118/1.4823765.
  • Peer Reviewed
• [Journal Article] 保健医療分野における情報視覚化 (2013)
  • Author(s): 豊田修一,片貝智恵,仁木登
  • Journal Title: 情報処理学会デジタルプラクティス Volume: Vol.4,No.3 Pages: 251-259
  • URL: https://ipsj.ixsq.nii.ac.jp/ej/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=94253&item_no=1&page_id=13&block_id=8
  • Peer Reviewed
• [Journal Article] 胸部マルチスライスCT 画像を用いた骨粗鬆症診断支援システム (2013)
  • Author(s): 高橋英治,鈴木秀宣,河田佳樹,仁木登,中野恭幸,上野淳二,原田雅史,森山紀之
  • Journal Title: 電子情報通信学会論文誌 Volume: Vol.J.96-D,No.4 Pages: 892-900
  • URL: http://ci.nii.ac.jp/naid/110009596337
  • Peer Reviewed
• [Journal Article] 胸部マルチスライスCT 画像における葉間裂抽出法 (2013)
  • Author(s): 松廣幹雄,鈴木秀宣,河田佳樹,仁木登,上野淳二,中野恭幸,小川惠美子,室繁郎,大松広伸,森山紀之
  • Journal Title: 電子情報通信学会論文誌 Volume: Vol.J.96-D,No.4 Pages: .834-843
  • URL: http://ci.nii.ac.jp/naid/110009596331
  • Peer Reviewed
• [Journal Article] A method for determining the modulation transfer function from thick microwire profiles measured with x-ray microcomputed tomography (2012)
  • Author(s): Y.Nakaya, Y.Kawata, N.Niki, K.Umetani, H.Ohmatsu, N.Moriyama
  • Journal Title: Medical Physics Volume: Vol.39, No.7 Pages: 4347-4364
  • DOI: 10.1118/1.4729711
  • Peer Reviewed
• [Journal Article] Quantitative classification based on CT histogram analysis of non-small cell lung cancer: Correlation with histopathological characteristics and recurrence-free survival (2012)
  • Author(s): Y.Kawata, N.Niki, H.Ohmatsu, M.Kusumoto, T.Tsuchida, K.Eguchi, M.Kaneko, N.Moriyama
  • Journal Title: Medical Physics Volume: Vol.39, No.2 Pages: 988-1000
  • DOI: 10.1118/1.3679017
  • Peer Reviewed
• [Journal Article] Measurements of multidetector CT surface dose distributions using a film dosimeter and chest phantom (2011)
  • Author(s): M.Tominaga, Y.Kawata, N.Niki, N.Moriyama, K.Yamada, J.Ueno, H.Nishitani
  • Journal Title: Medical Physics Volume: Vol.38, No.5 Pages: 2467-2478
  • DOI: 10.1118/1.3570769
  • Peer Reviewed
• [Journal Article] Influence of slice thickness on diagnoses of pulmonary nodules using low-dose CT: potential dependence of detection and diagnostic agreement on features and location of nodule (2011)
  • Author(s): M.Sinsuat, S.Saita, Y.Kawata, N.Niki, H.Ohmatsu, T.Tsuchida, R.Kakinuma M.Kusumoto, K.Eguchi, M.Kaneko, H.Morikubo, N.Moriyama
  • Journal Title: Academic Radiology Volume: Vol.18, No.5 Pages: 594-604
  • DOI: 10.1016/j.acra.2011.01.007
  • Peer Reviewed
• [Journal Article] 肺がんCT 検診のための画像選別法 (2010)
  • Author(s): 鈴木秀宣,財田伸介,河田佳樹,仁木登,西谷弘,大松広伸,土田敬明,江口研二,金子昌弘,森山紀之
  • Journal Title: 電子情報通信学会論文誌 Volume: Vol.J93-D,No.4 Pages: 522-534
  • URL: http://ci.nii.ac.jp/naid/110007593186
  • Peer Reviewed
• [Journal Article] 肺がんCT 検診の比較読影支援システム (2010)
  • Author(s): 久保満,鈴木秀宣,財田伸介,河田佳樹,仁木登,大松広伸,江口研二,金子昌弘,森山紀之
  • Journal Title: 電子情報通信学会論文誌 Volume: Vol.J93-D,No.1 Pages: 47-58
  • URL: http://ci.nii.ac.jp/naid/110007503503
  • Peer Reviewed
• [Presentation] Potential usefulness of a topic model-based categorization of lung cancers as quantitative CT biomarkers for predicting the recurrence risk after curative resection (2014)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20140215-20
• [Presentation] Longitudinal follow-up study of smoking-induced emphysema progression in low-dose CT screening of lung cancer (2014)
  • Author(s): H.Suzuki
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20140215-20
• [Presentation] Microstructure analysis of the pulmonary lung of the secondary lobules by a synchrotron radiation CT (2014)
  • Author(s): Y.Fukuoka
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20140215-20
• [Presentation] Tracking time interval changes of pulmonary nodules on follow-up 3D CT images via image-based risk score of lung cancer (2013)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida, USA)
  • Year and Date: 20130209-14
• [Presentation] Extraction method of interlobar fissure based on multi-slice CT images (2013)
  • Author(s): M.Matsuhiro
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 20130209-14
• [Presentation] Blood vessel-based liver segmentation through the portal phase of a CT dataset (2013)
  • Author(s): A.S.Maklad
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 20130209-14
• [Presentation] Multiscale image analysis of lung CT images (2013)
  • Author(s): N.Niki
  • Organizer: MICCAI Workshop 2013
  • Place of Presentation: Nagoya University (Aichi)
  • Year and Date: 2013-09-26
  • Invited
• [Presentation] Stochastic tracking of small pulmonary vessels in human lung alveolar walls using synchrotron radiation micro CT images (2013)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 2013-09-14
• [Presentation] 肺のCT 画像解析 (2013)
  • Author(s): 仁木登
  • Organizer: 第5回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 徳島大学(徳島県)
  • Year and Date: 2013-01-12
• [Presentation] Image-based computer-aided prognosis of lung cancer: Predicting patient recurrent-free survival via a variational Bayesian mixture modeling framework for cluster analysis of CT histograms (2012)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20120204-09
  • Invited
• [Presentation] Amethod for modulation transfer function determination from blood vessel profiles measured in computed tomography (2012)
  • Author(s): Y.Nakaya
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20120204-09
• [Presentation] Extraction of liver volumetry based on blood vessel from the portal phase CT dataset (2012)
  • Author(s): A.S.Maklad
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20120204-09
• [Presentation] Computer aided diagnosis for osteoporosis based on spinal column structure analysis (2012)
  • Author(s): E.Takahashi
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20120204-09
• [Presentation] Segmentation algorithm of colon based on multi-slice CT colonography (2012)
  • Author(s): Y.Hu
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20120204-09
• [Presentation] 肺のCT 画像解析 (2012)
  • Author(s): 仁木登
  • Organizer: 第21回日本コンピュータ外科学会大会会
  • Place of Presentation: あわぎんホール(徳島県)
  • Year and Date: 2012-11-02
• [Presentation] 肺がん・COPD・骨粗鬆症のCT 画像解析 (2012)
  • Author(s): 仁木登
  • Organizer: 第4回呼吸機能イメージング研究会学術集会
  • Place of Presentation: ピアザ淡海(滋賀県)
  • Year and Date: 2012-02-11
  • Invited
• [Presentation] 胸部3 次元CT画像を用いた肺がんの鑑別診断支援 (2012)
  • Author(s): 河田佳樹
  • Organizer: 電子情報通信学会技術研究報告医用画像
  • Place of Presentation: ぶんかテンブス館(沖縄県那覇市)
  • Year and Date: 2012-01-19
  • Invited
• [Presentation] Computer aided diagnosis for chest CT images (2012)
  • Author(s): N.Niki
  • Organizer: The 2012 International Workshop on Advanced Image Technology
  • Place of Presentation: Hotel Majestic Saigon (Ho Chi Minh City, Vietnam)
  • Year and Date: 2012-01-09
  • Invited
• [Presentation] Human pulmonary acinar airspace segmentation from three-dimensional synchrotron radiation micro CT images of the secondary pulmonary lobule (2011)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 20110212-17
• [Presentation] Classification algorithm of lung lobe for lung disease cases based on multi-slice CT images (2011)
  • Author(s): M.Matsuhiro
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 20110212-17
• [Presentation] Developments of thrombosis detection algorithm using the contrast enhanced CT images (2011)
  • Author(s): J.Oya
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Disney Coronado Springs resort 国際会議場(Lake Buena Vista, Florida USA)
  • Year and Date: 20110212-17
• [Presentation] Microstructural analysis of secondary pulmonary lobule imaged by synchrotron radiation micro CT using offset scan mode (2010)
  • Author(s): Y.Kawata
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20100213-18
• [Presentation] Computer aided diagnosis for osteoporosis using multi-slice CT images (2010)
  • Author(s): E.Takahashi
  • Organizer: Proc. SPIE Medical Imaging
  • Place of Presentation: Town & Country Resort and Convention Center (San Diego, California, USA)
  • Year and Date: 20100213-18
• [Presentation] Chest CT images (2010)
  • Author(s): N.Niki
  • Organizer: International Conference on Medical Biometrics
  • Place of Presentation: The Hong Kong Polytechnic University (Hong Kong).
  • Year and Date: 2010-06-30
  • Invited
• [Presentation] Computational anatomy for CAD (2010)
  • Author(s): N.Niki
  • Organizer: International Journal of Computer Assisted Radiology and Surgery
  • Place of Presentation: University Medical Center (Switzerland)
  • Year and Date: 2010-06-26
  • Invited
• [Presentation] 肺がんにおけるCAD:検出から治療への応用 (2010)
  • Author(s): 仁木登
  • Organizer: 第2回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県)
  • Year and Date: 2010-01-31
  • Invited
• [Book] 第6 章コンピュータ支援検出/診断 2 CT 画像,実践医用画像解析ハンドブック (2012)
  • Author(s): 仁木登,河田佳樹,鈴木秀宣
  • Total Pages: 605-614 (835)
  • Publisher: 株式会社オーム社
• [Book] II.画像処理と解析 2.X 線CT 画像 2.3 肺,医用画像ハンドブック (2012)
  • Author(s): 仁木登,河田佳樹,鈴木秀宣
  • Total Pages: 576-582 (777)
  • Publisher: 日本医用画像工学会
• [Book] 肺がんCT 検診のコンピュータ支援診断(CAD), 医用画像ハンドブック (2012)
  • Author(s): 仁木登,河田佳樹
  • Total Pages: 761-777 (1571)
  • Publisher: 株式会社オーム社
• [Patent(Industrial Property Rights)] 画像処理装置、画像処理方法、画像処理装置の制御プログラム、記録媒体 (2013)
  • Inventor(s): 仁木登
  • Industrial Property Rights Holder: 徳島大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許願2013-205014号
  • Filing Date: 2013-09-30
• [Patent(Industrial Property Rights)] 画像処理装置、画像処理方法、画像処理装置の制御プログラム、記録媒体 (2013)
  • Inventor(s): 仁木登
  • Industrial Property Rights Holder: 徳島大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許願2013-032593号
  • Filing Date: 2013-02-21
• [Patent(Industrial Property Rights)] 画像処理装置、画像処理方法、制御プログラム、および記録媒体 (2013)
  • Inventor(s): 仁木登
  • Industrial Property Rights Holder: 徳島大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特許願2013-031517号
  • Filing Date: 2013-02-20