2013 Fiscal Year Final Research Report
| Project Area | Organic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials |
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| Project/Area Number |
21106002
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
YOSHIDA Jun-ichi 京都大学, 工学(系)研究科(研究院), 教授 (30127170)
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| Co-Investigator(Kenkyū-buntansha) |
NOKAMI Toshiki 京都大学, 大学院工学研究科, 講師 (60402963)
SHIMIZU Akihiro 京都大学, 大学院工学研究科, 助教 (30584263)
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| Project Period (FY) |
2009-07-23 – 2014-03-31
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| Keywords | 有機合成 / 炭素カチオン / 炭素アニオン / 有機電解 / フロー合成 |
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| Research Abstract |
We developed the time integration of electrochemical and chemical reactions using the cation pool method, and applied it to the synthesis of functional materials such as dendritic molecules. The space integration of cationic reactions using flow microreactors was also achieved, and new transformations such as cationic three-component coupling reactions were developed. The space integration of anionic species was also achieved. We showed that a flow microreactor enables the generation and reactions of highly unstable organolithium species such as aryllithium species bearing ketone carbonyl groups. The method was successfully applied to the formal synthesis of a natural product. We also showed that flow microreactors allow generation and use of configurationally unstable chiral organolithium species.
In summary, we developed various transformations that are difficult to achieve by conventional methods based on reaction integration via short-lived, highly reactive ionic species.
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