2013 Fiscal Year Final Research Report
Synthetic Studies on Bioactive Natural Products utilizing Integrated
| Project Area | Organic Synthesis based on Integration of Chemical Reactions. New Methodologies and New Materials |
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| Project/Area Number |
21106009
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Waseda University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAYASHI Nobuyuki 早稲田大学, 理工学術院, 助手 (90514208)
NIWA Takashi 早稲田大学, 理工学術院, 助教 (30584396)
FUJII Tomohiro 早稲田大学, 理工学術院, 助手 (00707911)
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| Project Period (FY) |
2009-07-23 – 2014-03-31
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| Keywords | 反応集積化 / 不斉触媒反応 / 連続反応 / 不斉全合成 / 生物活性物質 |
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| Research Abstract |
We have studied the total synthesis of bioactive natural products via integrated reactions developed by focusing our attention on reactive intermediates. (1)Anion: Total syntheses of (-)-scabronines G, A, D, and (-)-episcabronine A have been achieved. Highly stereoselective Michael reaction cascades have been developed. (2)Cation: A formal enantioselective total synthesis of (-)-taxol and a first total synthesis of (+)-ophiobolin A have been achieved. (3)Transition metal: Total synthesis of hyperforin, formal enantioselective total syntheses of nemorosone, garsubellin A, and clusianone have been achieved. A first non-heme Fe(III) complex that catalyzes highly enantioselective asymmetric epoxidation has been synthesized. A first enantioselective total synthesis of (+)-colletoic acid, formal total syntheses of (-)-platencin and (-)-platensimycin, integrated syntheses of a-alkylidene b-keto imide, highly enantioselective [4+2]cycloaddition and Hosomi-Sakurai reaction have been achieved.
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