2013 Fiscal Year Final Research Report
Development and application of a database of intrinsic protein disorder
| Project Area | Target recognition and expression mechanism of intrinsically disordered protein |
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| Project/Area Number |
21113007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
OTA Motonori 名古屋大学, 情報科学研究科, 教授 (40290895)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUCHI Satoshi 前橋工科大学, 工学部, 准教授 (70360336)
HIROAKI Hidekazu 名古屋大学, 創薬科学研究科, 教授 (10336589)
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| Project Period (FY) |
2009-07-23 – 2014-03-31
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| Keywords | データベース / バイオインフォマティクス / 構造・機能予測 / 変性とフォールディング |
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| Research Abstract |
Intrinsically disordered proteins (IDPs) are those that do not adopt their unique tertiary structures under physiological condition, if isolated from their binding partners. The structural and functional information for IDPs are not adequate enough, because they have been paid attention recently. They play significant roles in the translational activation or signal transduction. Construction of qualified database is mandatory to the deep understanding of IDPs. We have developed IDEAL database using the information of UniProt and PDB as the starting point. We arranged manual-annotation procedures and devised several data-handling tools. From the November 2011, IDEAL is open to the public. Especially, it presents functional regions in disordered regions that exhibit disorder-order transition upon binding of interaction partners, as protean segments.
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