2013 Fiscal Year Final Research Report
Genetic approaches to physiological functions of long noncoding RNA machinery
| Project Area | Functional machinery for non-coding RNAs |
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| Project/Area Number |
21115007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kobe University (2011-2013)
National Institutes of Natural Sciences Okazaki Research Facilities (2009-2010) |
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Principal Investigator |
KAGEYAMA Yuji 神戸大学, 遺伝子実験センター, 准教授 (90335480)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Shinichi (50324679)
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| Project Period (FY) |
2009-07-23 – 2014-03-31
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| Keywords | ショウジョウバエ / マウス / 非コードRNA / 神経発生 / 不活性化X / Xist / ペプチド |
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| Research Abstract |
Current research project demonstrates biological importance of long noncoding RNA by genetic approaches using fruit flies and mice. Mutational studies showed that 1) high-molecular weight long noncoding RNA plays an impotent role in formation of neural circuits in the adult fly brain and 2) RNA binding protein hnRNP U, which carries both an RNA binding domain and a chromatin binding domain, is essential for localization of Xist RNA, an essential component in dosage compensation in mammals. In the course of study, we found that some of the putative long noncoding RNA include short ORFs that encodes extremely small peptides and those peptides, at least in some cases, regulate gene expression in transcriptional network.
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[Journal Article] The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing2014
Author(s)
Barry G, Briggs JA, Vanichkina DP, Poth EM, Beveridge NJ, Ratnu VS, Nayler SP, Nones K, Hu J, Bredy TW, Nakagawa S, Rigo F, Taft RJ, Cairns MJ, Blackshaw S, Wolvetang EJ, Mattick JS
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Journal Title
Mol Psychiatry
Volume: 19(4)
Pages: 486-494
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[Journal Article]2014
Author(s)
Hirose T, Virnicchi G, Tanigawa A, Naganuma T, Li R, Kimura H, Yokoi T, Nakagawa S, Benard M, Fox AH, Pierron G
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Journal Title
Mol Biol Cell
Volume: 25(1)
Pages: 169-183
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[Journal Article] The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis2013
Author(s)
Nishimoto Y, Nakagawa S, Hirose T, Okano HJ, Takao M, Shibata S, Suyama S, Kuwako K, Imai T, Murayama S, Suzuki N, Okano H
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Journal Title
Mol Brain
Volume: 6
Pages: 31
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