Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Innate immune sensors detect not only pathogen- but also host-derived factors such as nucleic acids and cause inflammatory responses. Dendritic cells or macrophages play critical roles in this inflammation, which we call homeostatic inflammation. This study clarified molecular mechanisms regulating the production of type I interferons or proinflammatory cytokines induced by nucleic acid sensors and keeping appropriate responses. This study also generated gene-manipulating mice which should be useful for clarifying the critical roles of dendritic cell subsets in homeostatic inflammation.
Attribution of KAKENHI