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2013 Fiscal Year Final Research Report

Social epidemiology research of mechanisms of health inequality

Planned Research

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Project AreaElucidation of social stratification mechanism and control over health inequality in contemporary Japan: New interdisciplinary area of social and health sciences
Project/Area Number 21119003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe University of Tokyo

Principal Investigator

NORITO Kawakami  東京大学, 医学(系)研究科(研究院), 教授 (90177650)

Co-Investigator(Kenkyū-buntansha) FUKUDA Yoshiharu  山口大学, 医学部, 教授 (60252029)
OHIRA Hideki  名古屋大学, 大学院環境学研究科, 教授 (90221837)
ROKUTAN Kazuhiro  徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (10230898)
SHIMAZU Akihito  東京大学, 大学院医学系研究科, 准教授 (80318724)
ARAKI Tsuyoshi  東京大学, 医学部附属病院, 特任准教授 (00456120)
FUJIWARA Takeo  独立行政法人国立成育医療研究センター研究所, 成育社会医学研究部, 部長 (80510213)
Co-Investigator(Renkei-kenkyūsha) KASAI Kiyoto  東京大学, 医学部附属病院, 教授 (80322056)
HONJO Kaori  大阪大学, グローバルコラボレーションセンター, 特任准教授 (60448032)
Project Period (FY) 2009-07-23 – 2014-03-31
Keywords社会医学 / 心理学 / ストレス / 脳・神経 / 遺伝子
Research Abstract

The research shows the association of socioeconomic status (SES) such as income, educational attainment, employment, with health behaviors, preventive service use, circulatory disease risk factors, nutrition, poor mental health, somatic complaints, and the use of medical care. The associations between SES and health were mediated by health behaviors and inner and outer psychosocial factors. Social class and related psychosocial factors may affect brain function. Among people with low social class, brain and somatic responses may be blunted in risky decision making, with weakened typical reactions in prefrontal cortex, insula, striatum, and autonomic nervous system. Psychological reactions associated with social class were found to be associated with abnormal gene expressions related to immune and inflammation.

  • Research Products

    (20 results)

All 2014 2013 2012 2011 2010 2009 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (3 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Associationof subjectiveand objective socioeconomic status with subjective mental health and mental disorders among Japanese men and women2014

    • Author(s)
      Honjo K, Kawakami N, Tsuchiya M,Sakurai K; WMH-J 2002窶・006 Survey Group
    • Journal Title

      Int J Behav Med.

      Volume: 21(3) Pages: 421-9

    • Peer Reviewed
  • [Journal Article] Health inequalities in Japan : the role of material, psychosocial, social relational and behavioural factors2014

    • Author(s)
      Hiyoshi A, Fukuda Y, Shipley MJ, Brunner EJ
    • Journal Title

      Soc Sci Med.

      Volume: 104 Pages: 201-9

    • Peer Reviewed
  • [Journal Article] Income inequality, parental socioeconomic status and birth outcomes in Japan2013

    • Author(s)
      Fujiwara T, Ito J, Kawachi I
    • Journal Title

      Am J Epidemiol.

      Volume: 177(10) Pages: 1042-52

    • Peer Reviewed
  • [Journal Article] Chronic academic stress increases a group of microRNAs in peripheral blood2013

    • Author(s)
      Honda M, Kuwano Y, Katsuura-Kamano S, Kamezaki Y, Fujita K, Akaike Y, Kano S, Nishida K, Masuda K, Rokutan K
    • Journal Title

      PLoS One. Oct9

      Volume: 8(10) Pages: e75960

    • Peer Reviewed
  • [Journal Article] Disruption of function-structure coupling in brain regions sub-serving self monitoring in schizophrenia2013

    • Author(s)
      Araki T, Niznikiewicz M, Kawashima T, Nestor PG, Shenton ME, McCarley RW
    • Journal Title

      Schizophr Res.

      Volume: 146 Pages: 336-43

    • Peer Reviewed
  • [Journal Article] A new theory-based social classification in Japan and its validation using historically collectedinformation2013

    • Author(s)
      Hiyoshi A, Fukuda Y, Shipley MJ, Bartley M, Brunner EJ
    • Journal Title

      Soc Sci Med.

      Volume: 87 Pages: 84-92

    • Peer Reviewed
  • [Journal Article] Inequalities in self-ratedhealth in Japan 1986-2007 according to household income and a novel occupational classification : national sampling survey series2013

    • Author(s)
      Hiyoshi A, Fukuda Y, Shipley MJ, Brunner EJ
    • Journal Title

      J Epidemiol Community Health.

      Volume: 67 Pages: 960-5

    • Peer Reviewed
  • [Journal Article] Influences of income and employment on psychological distress and depression treatment in Japanese adults2012

    • Author(s)
      Fukuda Y, Hiyoshi A
    • Journal Title

      Environ. Health. Prev. Med.

      Volume: 17 Pages: 10-7

    • Peer Reviewed
  • [Journal Article] Factors influencing time lag between first parental concern and first visit to child psychiatric services among children with autism spectrum disorders in Japan2011

    • Author(s)
      Fujiwara T, Okuyama M, Funahashi K
    • Journal Title

      Research in Autism Spectrum Disorders.

      Volume: 5(1) Pages: 584-91

    • Peer Reviewed
  • [Journal Article] Association of occupation, employment contract, and company size with mental health in a national representative sample ofemployees in Japan2010

    • Author(s)
      Inoue A, Kawakami N, Tsuchiya M, Sakurai K, Hashimoto H
    • Journal Title

      J Occup Health.

      Volume: 52(4) Pages: 227-40

    • Peer Reviewed
  • [Journal Article] Associations of serious mental illness with earnings : results from the WHO World Mental Health surveys2010

    • Author(s)
      Levinson D, Lakoma MD, Petukhova M, Schoenbaum M, Zaslavsky AM, Angermeyer M, Borges G, Bruffaerts R, de Girolamo G, de Graaf R, Gureje O, Haro JM, Hu C, Karam AN, Kawakami N, Lee S, Lepine JP, Browne MO, Okoliyski M, Posada-Villa J, Sagar R, Viana MC, Williams DR, Kessler RC
    • Journal Title

      Br J Psychiatry.

      Volume: 197 Pages: 114-21

    • Peer Reviewed
  • [Journal Article] Regulation of natural killer cell redistribution by prefrontal cortex during stochastic learning2009

    • Author(s)
      Ohira H, Fukuyama S, Kimura K, Nomura M, Isowa T, Ichikawa N, Matsunaga M, Shinoda J, Yamada J
    • Journal Title

      Neuroimage.

      Volume: 47 Pages: 897-907

    • Peer Reviewed
  • [Journal Article] How job demands affect an intimate partner : a test of the spillover-crossover model in Japan2009

    • Author(s)
      Shimazu A, Bakker AB, Demerouti E
    • Journal Title

      J Occup Health.

      Volume: 51 Pages: 239-48

    • Peer Reviewed
  • [Presentation] シンポジウム心の健康の社会格差 : そのメカニズムを解明する2013

    • Author(s)
      川上憲人
    • Organizer
      第29回日本ストレス学会学術総会
    • Place of Presentation
      徳島大学
    • Year and Date
      20131108-09
  • [Presentation] Cardiovascular risk factors and socioeconomic status in Japanese adults2012

    • Author(s)
      Fukuda Y
    • Organizer
      Sixth ICOH International Conference on Work Environment and Cardiovascular Diseases, Symposium: Social class and cardiovascular health
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20120327-30
  • [Presentation] The Japanese environment and children's study2011

    • Author(s)
      Fujiwara T
    • Organizer
      Pediatric Academic Societiesand AsianSociety for Pediatric Research Joint Meeting
    • Place of Presentation
      Denver, CO, USA
    • Year and Date
      20110430-0503
  • [Remarks]

    • URL

      http://mental.m.u-tokyo.ac.jp/sdh/

  • [Patent(Industrial Property Rights)] うつ病の診断のためのデータの提供方法2011

    • Inventor(s)
      六反一仁、亀崎佳子、納屋伸一、比嘉友紀子、菅井睦美、池田真弘、保坂由美子、樋口景子、神里茉衣
    • Industrial Property Rights Holder
      片倉工業株式会社、徳島大学
    • Industrial Property Rights Type
      特許権
    • Industrial Property Number
      PCT/JP2011/053836
    • Filing Date
      2011-02-22
    • Overseas
  • [Patent(Industrial Property Rights)] 慢性ストレスの評価方法2011

    • Inventor(s)
      六反一仁、河合智子、亀崎佳子
    • Industrial Property Rights Holder
      片倉工業株式会社、徳島大学
    • Industrial Property Rights Type
      特許権
    • Industrial Property Number
      特許第4717962
    • Acquisition Date
      2011-04-08
    • Overseas
  • [Patent(Industrial Property Rights)] 慢性ストレスの評価方法2010

    • Inventor(s)
      六反一仁、河合智子、亀崎佳子
    • Industrial Property Rights Holder
      片倉工業株式会社、徳島大学
    • Industrial Property Rights Type
      特許権
    • Industrial Property Number
      特願2010-533154
    • Filing Date
      2010-08-19
    • Overseas

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Published: 2015-06-25  

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