2023 Fiscal Year Final Research Report
Muscle cell swarm intelligence: Understanding phase transition-like dynamics of muscle remodeling during insect metamorphosis
| Project Area | Heterogeneous swarm intelligence: Innovative design of swarm intelligence inspired by collective behavior of variety of cells |
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| Project/Area Number |
21H05105
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (II)
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| Research Institution | Osaka University (2023)
Tohoku University (2021-2022) |
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Principal Investigator |
Umetsu Daiki 大阪大学, 大学院理学研究科, 講師 (60620474)
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | 群知能 / ヘテロ性 / 細胞遊走 / 組織リモデリング / 骨格筋 / 形態形成 / 自己組織化 / ライブイメージング |
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| Outline of Final Research Achievements |
Similar to the phenomenon of "swarm intelligence" observed in animal swarms such as birds and fish, there is a process in cellular societies where migratory cell populations build ordered structures. This study aimed to elucidate the principles by which heterogeneous cell populations form ordered structures, using the dynamics of muscle cell "swarms" observed during the metamorphosis of Drosophila as a model. Through quantitative analysis of cell dynamics in vivo and simulation analysis using mathematical models, it was demonstrated that heterogeneous groups of two sizes of migrating cells intermingle and create a reticular pattern through interspecies interactions. This revealed part of the mechanism by which a limited number of self-propelling agents maximize the area that they cover, providing insights for engineering applications.
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| Free Research Field |
細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
これまでの細胞遊走研究では、外界からの誘引／忌避因子や基質の硬さに対する応答など、細胞が刺激に対して決定論的に動きを制御する仕組みが研究対象であった。一方で、群としての挙動には確率論的な側面が大きく、従来の細胞遊走研究とは性質が異なることから、本研究を通じて得られた成果は細胞生物学などの関連分野に新規の視点をもたらす。さらに、自律分散制御原理の理解から工学分野への波及効果も期待される。また、筋組織は癌の致死性の要因、免疫系との連関など、生命維持に非常に重要な生理的役割を持つことが近年の研究で明らかになってきている。将来的に筋組織機能の改善を介した新たな医療技術の開発に役立つことも期待される。
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