• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Final Research Report

Multicellular Information Representation in the Animal Brains

Planned Research

  • PDF
Project AreaMulticellular neurobiocomputing
Project/Area Number 21H05166
Research Category

Grant-in-Aid for Transformative Research Areas (B)

Allocation TypeSingle-year Grants
Review Section Transformative Research Areas, Section (IV)
Research InstitutionDoshisha University

Principal Investigator

Masamizu Yoshito  同志社大学, 脳科学研究科, 教授 (90608530)

Co-Investigator(Kenkyū-buntansha) 神谷 温之  北海道大学, 医学研究院, 教授 (10194979)
Project Period (FY) 2021-08-23 – 2024-03-31
Keywords多細胞バイオ計算 / 損傷耐性 / 自己組織性 / カルシウムイメージング / 脳梗塞 / in vivoカルシウムイメージング
Outline of Final Research Achievements

We developed systems of in vivo calcium imaging using the multi-point laser scanning confocal microscopy, which enables wide-field imaging, and the two-photon excitation laser scanning microscopy, which allows deep-depth imaging. Next, we established a system to damage the primary motor cortex using rose bengal. Furthermore, we confirmed the anatomical and functional connections between the transplanted neuronal spheroid and cerebral neocortex. A bio-inspired mathematical model of axonal conduction has also been constructed.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

脳をバイオコンピューティングシステムとして扱った場合の特徴は、その損傷耐性と自己組織性にある。本研究で構築した実験系を用いることによって大脳皮質損傷後の自己修復、さらには損傷部位への神経細胞塊移植による自己組織的機能補填の脳内基盤が解明され、ロバスト性の高いコンピューティングシステム設計への貢献が期待される。

URL: 

Published: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi