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2022 Fiscal Year Annual Research Report

定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立

Planned Research

Project AreaLife Science Innovation Driven by Supersulfide Biology
Project/Area Number 21H05263
Research InstitutionTohoku University

Principal Investigator

赤池 孝章  東北大学, 医学系研究科, 教授 (20231798)

Co-Investigator(Kenkyū-buntansha) 居原 秀  大阪公立大学, 大学院理学研究科, 教授 (60254447)
Project Period (FY) 2021-09-10 – 2026-03-31
Keywords超硫黄分子 / 超硫黄オミックス / 超硫黄イメージング / 国際標準化
Outline of Annual Research Achievements

本研究では、定量的超硫黄オミックスおよびイメージング技術の開発と世界標準化プロトコールとデータベースを構築する。この分析技術を基に、新たな疾病、老化制御・長寿医療の研究基盤を確立する。例えば、超硫黄オミックスやイメージングにより生体の硫黄代謝動態をモニタリングすることで、日常的な健康管理のみならず、動脈硬化などの生活習慣病、慢性炎症性肺疾患、心筋梗塞・心不全などの難治性心疾患などにおける病状把握や病態解明や予防・治療法の開発に繋げる。さらに、本超硫黄オミックス解析設備と技術を当該研究領域のバーチャルハブとして運用することで、総括班のミッションである領域内での横断的連携の強化のみならず、総括班にて先導する超硫黄のグローバルコンソーシアム構想と国際標準化・データベース化を支援し着実に遂行する。このことにより超硫黄生物学を世界的レベルで展開する。これまでに、超硫黄分子を安定的に捕捉するアルキル化プローブを用いた定量的超硫黄オミックス解析法を開発することにより、哺乳類・ヒトの細胞内に超硫黄分子が豊富に生成されることを見出した。加えて、単離ミトコンドリアを用いたシングル(単一)ミトコンドリアイメージングシステムを構築し、超硫黄分子を介したミトコンドリア膜電位形成を精度良く解析することで、真核生物における硫黄呼吸が、酸素呼吸とのハイブリット型システムであることを明らかにした。本年度では、環状八硫黄S8を特異的に捕捉する分子カプセルを用いた解析により、広く自然界に存在する環化S8が、生体内に高濃度で生成・蓄積していることを見出した。さらに、環化S8は、ミトコンドリアの硫黄依存型エネルギー代謝に関与する一方で、脂質過酸化を強力に制御することを明らかにした。引き続き、定量的な超硫黄分析技術を基にした超硫黄生物学研究を国際的に強力に推進する。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

超硫黄分子の定量的オミックス・イメージング技術開発と標準化プロトコールの確立に向けた解析を行ったが、そのために本研究の当初目的の一つである、環化S8の定量解析法の開発とその生理機能解明に関する知見をさらに深めることができ、研究はおおむね順調に進展していると評価できる。

Strategy for Future Research Activity

本研究の当初目的に照らして、研究遂行の上での問題はなく順調に研究が進展している。今後は、定量的硫黄メタボローム・プロテオームのみならず、超硫黄オミックスイメージングの開発を推進する。さらに、本領域で独自に確立する定量的超硫黄オミックスのプロトコールを国際標準化して国内外の超硫黄生物学を先導する。

  • Research Products

    (66 results)

All 2024 2023 2022 Other

All Int'l Joint Research (4 results) Journal Article (31 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 31 results,  Open Access: 31 results) Presentation (18 results) (of which Int'l Joint Research: 9 results,  Invited: 15 results) Book (5 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] German Cancer Research Center/Helmholtz(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      German Cancer Research Center/Helmholtz
  • [Int'l Joint Research] National Institute of Oncology(ハンガリー)

    • Country Name
      HUNGARY
    • Counterpart Institution
      National Institute of Oncology
  • [Int'l Joint Research] University of Vermont/Brown University(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      University of Vermont/Brown University
  • [Int'l Joint Research] Birmingham(英国)

    • Country Name
      UNITED KINGDOM
    • Counterpart Institution
      Birmingham
  • [Journal Article] 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels2024

    • Author(s)
      Cui Qi、Shieh Meg、Pan Tony W.、Nishimura Akiyuki、Matsunaga Tetsuro、Kelly Shane S.、Xu Shi、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Chen Xiaoyan、Robinson Jerome R.、Qian Wei-Jun、Nishida Motohiro、Akaike Takaaki、Xian Ming
    • Journal Title

      Nature Communications

      Volume: 15 Pages: (2453)

    • DOI

      10.1038/s41467-024-46652-7

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential role of ROS - 8-Nitro-cGMP signaling in long-term memory of motor learning and cerebellar synaptic plasticity2024

    • Author(s)
      Kakizawa Sho、Arasaki Tomoko、Yoshida Ayano、Sato Ayami、Takino Yuka、Ishigami Akihito、Akaike Takaaki、Yanai Shuichi、Endo Shogo
    • Journal Title

      Redox Biology

      Volume: 70 Pages: (103053)

    • DOI

      10.1016/j.redox.2024.103053

    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of innate immune and inflammatory responses by supersulfides2024

    • Author(s)
      Tsutsuki Hiroyasu、Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
    • Journal Title

      International Immunology

      Volume: 36 Pages: 143~154

    • DOI

      10.1093/intimm/dxad057

    • Peer Reviewed / Open Access
  • [Journal Article] Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality2024

    • Author(s)
      Nishimura Akira、Yoon Sunghyeon、Matsunaga Tetsuro、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Morita Masanobu、Yoshitake Jun、Unno Yuka、Barayeu Uladzimir、Takata Tsuyoshi、Takagi Hiroshi、Motohashi Hozumi、van der Vliet Albert、Akaike Takaaki
    • Journal Title

      Redox Biology

      Volume: 69 Pages: (103018)

    • DOI

      10.1016/j.redox.2023.103018

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitative profiling of supersulfides naturally occurring in dietary meats and beans2024

    • Author(s)
      Kasamatsu Shingo、Kinno Ayaka、Miura Chiharu、Hishiyama Jun-ichi、Fukui Kensuke、Kure Shoji、Tsumura Kazunobu、Ida Tomoaki、Matsunaga Tetsuro、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Analytical Biochemistry

      Volume: 685 Pages: (115392)

    • DOI

      10.1016/j.ab.2023.115392

    • Peer Reviewed / Open Access
  • [Journal Article] Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates2024

    • Author(s)
      Sasama Yuji、Yoshimura Kentaro、Hoshino Marie、Sasa Kiyohito、Akaike Takaaki、Morita Masanobu、Baba Kazuyoshi、Shirota Tatsuo、Miyamoto Yoichi
    • Journal Title

      Journal of Oral Biosciences

      Volume: 66 Pages: 76~81

    • DOI

      10.1016/j.job.2023.11.004

    • Peer Reviewed / Open Access
  • [Journal Article] Redox regulation of xenobiotics by reactive sulfur and supersulfide species2024

    • Author(s)
      Zhang Tianli、Akaike Takaaki、Sawa Tomohiro
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 40 Pages: 679~690

    • DOI

      10.1089/ars.2022.0172

    • Peer Reviewed / Open Access
  • [Journal Article] Alkyl gallates inhibit serine O-acetyltransferase in bacteria and enhance susceptibility of drug-resistant Gram-negative bacteria to antibiotics2023

    • Author(s)
      Toyomoto Touya、Ono Katsuhiko、Shiba Tomoo、Momitani Kenta、Zhang Tianli、Tsutsuki Hiroyasu、Ishikawa Takeshi、Hoso Kanae、Hamada Koma、Rahman Azizur、Wen Liping、Maeda Yosuke、Yamamoto Keiichi、Matsuoka Masao、Hanaoka Kenjiro、Niidome Takuro、Akaike Takaaki、Sawa Tomohiro
    • Journal Title

      Frontiers in Microbiology

      Volume: 14 Pages: (1276447)

    • DOI

      10.3389/fmicb.2023.1276447

    • Peer Reviewed / Open Access
  • [Journal Article] Supersulfide biology and translational medicine for disease control2023

    • Author(s)
      Barayeu Uladzimir、Sawa Tomohiro、Nishida Motohiro、Wei Fan-Yan、Motohashi Hozumi、Akaike Takaaki
    • Journal Title

      British Journal of Pharmacology

      Volume: - Pages: - (in press)

    • DOI

      10.1111/bph.16271

    • Peer Reviewed / Open Access
  • [Journal Article] Untargeted polysulfide omics analysis of alternations in polysulfide production during the germination of broccoli sprouts2023

    • Author(s)
      Kasamatsu Shingo、Owaki Takuma、Komae Somei、Kinno Ayaka、Ida Tomoaki、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Redox Biology

      Volume: 67 Pages: (102875)

    • DOI

      10.1016/j.redox.2023.102875

    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP2023

    • Author(s)
      Yang Jiangning、Sundqvist Michaela L.、Zheng Xiaowei、Jiao Tong、Collado Aida、Tratsiakovich Yahor、Mahdi Ali、Tengbom John、Mergia Evanthia、Catrina Sergiu-Bogdan、Zhou Zhichao、Carlstrom Mattias、Akaike Takaaki、Cortese-Krott Miriam M.、Weitzberg Eddie、Lundberg Jon O.、Pernow John
    • Journal Title

      Journal of Clinical Investigation

      Volume: 133 Pages: (e167693)

    • DOI

      10.1172/JCI167693

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persulfide biosynthesis conserved evolutionarily in all organisms2023

    • Author(s)
      Ogata Seiryo、Matsunaga Tetsuro、Jung Minkyung、Barayeu Uladzimir、Morita Masanobu、Akaike Takaaki
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: 39 Pages: 983~999

    • DOI

      10.1089/ars.2023.0405

    • Peer Reviewed / Open Access
  • [Journal Article] Supersulfide catalysis for nitric oxide and aldehyde metabolism2023

    • Author(s)
      Kasamatsu Shingo、Nishimura Akira、Alam Md. Morshedul、Morita Masanobu、Shimoda Kakeru、Matsunaga Tetsuro、Jung Minkyung、Ogata Seiryo、Barayeu Uladzimir、Ida Tomoaki、Nishida Motohiro、Nishimura Akiyuki、Motohashi Hozumi、Akaike Takaaki
    • Journal Title

      Science Advances

      Volume: 9 Pages: (eadg8631)

    • DOI

      10.1126/sciadv.adg8631

    • Peer Reviewed / Open Access
  • [Journal Article] Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop2023

    • Author(s)
      Takeda Haruna、Murakami Shohei、Liu Zun、Sawa Tomohiro、Takahashi Masatomo、Izumi Yoshihiro、Bamba Takeshi、Sato Hideyo、Akaike Takaaki、Sekine Hiroki、Motohashi Hozumi
    • Journal Title

      Redox Biology

      Volume: 65 Pages: (102834)

    • DOI

      10.1016/j.redox.2023.102834

    • Peer Reviewed / Open Access
  • [Journal Article] Supersulphides provide airway protection in viral and chronic lung diseases2023

    • Author(s)
      Matsunaga Tetsuro、Sano Hirohito、Takita Katsuya、Morita Masanobu、Yamanaka Shun、Ichikawa Tomohiro、Numakura Tadahisa、Ida Tomoaki、Jung Minkyung、Ogata Seiryo、Yoon Sunghyeon、Fujino Naoya、Kyogoku Yorihiko、Akaike Takaaki、et al.
    • Journal Title

      Nature Communications

      Volume: 14 Pages: (4476)

    • DOI

      10.1038/s41467-023-40182-4

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Glutathione trisulfide prevents lipopolysaccharide-induced retinal inflammation via inhibition of proinflammatory cytokine production in glial cells2023

    • Author(s)
      Tawarayama Hiroshi、Umeki Kota、Inoue-Yanagimachi Maki、Takahashi Naoki、Hasegawa Hirokazu、Himori Noriko、Tsuda Satoru、Kunikata Hiroshi、Akaike Takaaki、Nakazawa Toru
    • Journal Title

      Scientific Reports

      Volume: 13 Pages: (11513)

    • DOI

      10.1038/s41598-023-38696-4

    • Peer Reviewed / Open Access
  • [Journal Article] Development of methods for quantitative determination of the total and reactive polysulfides: Reactive polysulfide profiling in vegetables2023

    • Author(s)
      Kasamatsu Shingo、Kinno Ayaka、Hishiyama Jun-ichi、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Food Chemistry

      Volume: 413 Pages: (135610)

    • DOI

      10.1016/j.foodchem.2023.135610

    • Peer Reviewed / Open Access
  • [Journal Article] Presence of Helicobacter cinaedi in atherosclerotic abdominal aortic aneurysmal wall2023

    • Author(s)
      Horii Shinichiro、Sugawara Hirofumi、Goto Hitoshi、Hashimoto Munetaka、Matsunaga Tetsuro、Akamatsu Daijirou、Tajima Yuta、Umetsu Michihisa、Akaike Takaaki、Kamei Takashi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 261 Pages: 35~41

    • DOI

      10.1620/tjem.2023.J049

    • Peer Reviewed / Open Access
  • [Journal Article] Cystathionine γ-lyase self-Inactivates by polysulfidation during cystine metabolism2023

    • Author(s)
      Araki Shoma、Takata Tsuyoshi、Ono Katsuhiko、Sawa Tomohiro、Kasamatsu Shingo、Ihara Hideshi、Kumagai Yoshito、Akaike Takaaki、Watanabe Yasuo、Tsuchiya Yukihiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Pages: (9982)

    • DOI

      10.3390/ijms24129982

    • Peer Reviewed / Open Access
  • [Journal Article] Reactive sulfur species omics analysis in the brain tissue of the 5xFAD mouse model of Alzheimer’s disease2023

    • Author(s)
      Kinno Ayaka、Kasamatsu Shingo、Akaike Takaaki、Ihara Hideshi
    • Journal Title

      Antioxidants

      Volume: 12 Pages: (1105)

    • DOI

      10.3390/antiox12051105

    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of sulfides and persulfides is not impeded by disruption of three canonical enzymes in sulfur metabolism2023

    • Author(s)
      Zainol Abidin Qamarul Hafiz、Ida Tomoaki、Morita Masanobu、Matsunaga Tetsuro、Nishimura Akira、Jung Minkyung、Hassan Naim、Takata Tsuyoshi、Ishii Isao、Kruger Warren、Wang Rui、Motohashi Hozumi、Tsutsui Masato、Akaike Takaaki
    • Journal Title

      Antioxidants

      Volume: 12 Pages: (868)

    • DOI

      10.3390/antiox12040868

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Polysulfide metabolizing enzymes influence SqrR-mediated sulfide-induced transcription by impacting intracellular polysulfide dynamics2023

    • Author(s)
      Shimizu Takayuki、Ida Tomoaki、Antelo Giuliano T、Ihara Yuta、Fakhoury Joseph N、Masuda Shinji、Giedroc David P、Akaike Takaaki、Capdevila Daiana A、Masuda Tatsuru
    • Journal Title

      PNAS Nexus

      Volume: 2 Pages: (pgad048)

    • DOI

      10.1093/pnasnexus/pgad048

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of NRF2 to sulfur metabolism and mitochondrial activity2023

    • Author(s)
      Alam Md Morshedul、Kishino Akihiro、Sung Eunkyu、Sekine Hiroki、Abe Takaaki、Murakami Shohei、Akaike Takaaki、Motohashi Hozumi
    • Journal Title

      Redox Biology

      Volume: 60 Pages: (102624)

    • DOI

      10.1016/j.redox.2023.102624

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Echinochrome prevents sulfide catabolism-associated chronic heart failure after myocardial infarction in mice2023

    • Author(s)
      Tang Xiaokang、Nishimura Akiyuki、Ariyoshi Kohei、Nishiyama Kazuhiro、Kato Yuri、Vasileva Elena、Mishchenko Natalia、Fedoreyev Sergey、Stonik Valentin、Kim Hyoung-Kyu、Han Jin、Kanda Yasunari、Umezawa Keitaro、Urano Yasuteru、Akaike Takaaki、Nishida Motohiro
    • Journal Title

      Marine Drugs

      Volume: 21 Pages: (52)

    • DOI

      10.3390/md21010052

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cysteine hydropersulfide reduces lipid peroxidation and protects against myocardial ischaemia-reperfusion injury - Are endogenous persulfides mediators of ischaemic preconditioning?2023

    • Author(s)
      Griffiths Kayleigh、Ida Tomoaki、Morita Masanobu、Lamb Reece J.、Lee Jordan J.、Frenneaux Michael P.、Fukuto Jon M.、Akaike Takaaki、Feelisch Martin、Madhani Melanie
    • Journal Title

      Redox Biology

      Volume: 60 Pages: (102605)

    • DOI

      10.1016/j.redox.2023.102605

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 8-Nitro-cGMP suppresses mineralization by mouse osteoblasts2022

    • Author(s)
      Kaneko Kotaro、Miyamoto Yoichi、Ida Tomoaki、Morita Masanobu、Yoshimura Kentaro、Nagasaki Kei、Toba Kazuki、Sugisaki Risa、Motohashi Hozumi、Akaike Takaaki、Chikazu Daichi、Kamijo Ryutaro
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 71 Pages: 191~197

    • DOI

      10.3164/jcbn.21-129

    • Peer Reviewed / Open Access
  • [Journal Article] Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress2022

    • Author(s)
      Akiyama Masahiro、Unoki Takamitsu、Aoki Hanako、Nishimura Akiyuki、Shinkai Yasuhiro、Warabi Eiji、Nishiyama Kazuhiro、Furumoto Yuka、Anzai Naohiko、Akaike Takaaki、Nishida Motohiro、Kumagai Yoshito
    • Journal Title

      Redox Biology

      Volume: 57 Pages: (102514)

    • DOI

      10.1016/j.redox.2022.102514

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an anti-oxidative intraocular irrigating solution based on reactive persulfides2022

    • Author(s)
      Kunikata Hiroshi、Tawarayama Hiroshi、Tsuda Satoru、Akaike Takaaki、Nakazawa Toru
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: (19243)

    • DOI

      10.1038/s41598-022-21677-4

    • Peer Reviewed / Open Access
  • [Journal Article] Coupled discrete phase model and Eulerian wall film model for numerical simulation of respiratory droplet generation during coughing2022

    • Author(s)
      Anzai Hitomi、Shindo Yugo、Kohata Yutaro、Hasegawa Masahiro、Takana Hidemasa、Matsunaga Tetsuro、Akaike Takaaki、Ohta Makoto
    • Journal Title

      Scientific Reports

      Volume: 12 Pages: (14849)

    • DOI

      10.1038/s41598-022-18788-3

    • Peer Reviewed / Open Access
  • [Journal Article] Shining a light on SSP4: A comprehensive analysis and biological applications for the detection of sulfane sulfurs2022

    • Author(s)
      Shieh Meg、Ni Xiang、Xu Shi、Lindahl Stephen P.、Yang Moua、Matsunaga Tetsuro、Flaumenhaft Robert、Akaike Takaaki、Xian Ming
    • Journal Title

      Redox Biology

      Volume: 56 Pages: (102433)

    • DOI

      10.1016/j.redox.2022.102433

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subtilase cytotoxin from Shiga-toxigenic Escherichia coli impairs the inflammasome and exacerbates enteropathogenic bacterial infection2022

    • Author(s)
      Tsutsuki Hiroyasu、Zhang Tianli、Yahiro Kinnosuke、Ono Katsuhiko、Fujiwara Yukio、Iyoda Sunao、Wei Fan-Yan、Monde Kazuaki、Seto Kazuko、Ohnishi Makoto、Oshiumi Hiroyuki、Akaike Takaaki、Sawa Tomohiro
    • Journal Title

      iScience

      Volume: 25 Pages: (104050)

    • DOI

      10.1016/j.isci.2022.104050

    • Peer Reviewed / Open Access
  • [Presentation] Supersulfide redox biology in life science and its translational medicine for disease control2024

    • Author(s)
      Takaaki Akaike
    • Organizer
      International Symposium “Signals for Human, Animal and Planetary Health: From Metabolites To Biological Interactions” (Tokyo Univ.)
    • Int'l Joint Research / Invited
  • [Presentation] 超硫黄分子のラマン分光イメージングを駆使した定量分析2023

    • Author(s)
      赤池 孝章
    • Organizer
      CREST「多細胞」領域,第5回領域会議プログラム・連携課題(浜松)
  • [Presentation] Supersulfides-mediated cellular protection from lipid oxidation and ferroptosis2023

    • Author(s)
      Takaaki Akaike
    • Organizer
      3rd Annual Meeting of the DFG founded Priority Programme (Heidelberg, Germany)
    • Int'l Joint Research / Invited
  • [Presentation] 超硫黄分子の発見と生理機能の解明2023

    • Author(s)
      赤池孝章
    • Organizer
      第96回日本生化学会大会・特別講演(福岡)
    • Invited
  • [Presentation] 定量的超硫黄オミックス・イメージング技術の開発と標準化プロトコールの確立2023

    • Author(s)
      赤池孝章
    • Organizer
      学術変革領域研究(A) 「硫黄生物学」第3回領域会議・超硫黄フロンティアシンポジウム2023(熊本)
  • [Presentation] Supersulfide biology and translational medicine for disease control2023

    • Author(s)
      Takaaki Akaike
    • Organizer
      Chemical Biology/Redox Biology Seminar (Rhode Island, USA)
    • Int'l Joint Research / Invited
  • [Presentation] 超硫黄分子によるエネルギー産生と過酸化脂質・カルボニル代謝制御2023

    • Author(s)
      赤池孝章
    • Organizer
      名古屋大学大学院生命農学研究科・特別セミナー(名古屋)
    • Invited
  • [Presentation] 無機超硫黄分子の検出定量と化学的反応性の理解2023

    • Author(s)
      赤池孝章
    • Organizer
      学術変革領域「硫黄生物学」領域プログレスミーティング(オンライン)
  • [Presentation] 活性酸素シグナル~酸素生物学~そして硫黄生物学:三つの領域のレドックス生命科学研究から俯瞰される世界2023

    • Author(s)
      赤池孝章
    • Organizer
      第96回日本細菌学会総会(姫路)
    • Invited
  • [Presentation] Nitric Oxide Synthases, a New Family of NADPH-Dependent Sulfur Oxidoreductases2023

    • Author(s)
      Takaaki Akaike
    • Organizer
      Nitric Oxide Gordon Research Conference
    • Int'l Joint Research / Invited
  • [Presentation] 空間生体情報メタオミックス解析と呼気医療2023

    • Author(s)
      赤池孝章
    • Organizer
      JASIS関西2023トピックスセミナー(大阪)
    • Invited
  • [Presentation] 環化超硫黄分子の生体内検出と機能解明2023

    • Author(s)
      赤池孝章
    • Organizer
      CREST多細胞領域 第4回領域会議プログラム(名古屋)
    • Invited
  • [Presentation] Physiological formation and function of new supersulfide, cyclic octa-sulfur in mammals2023

    • Author(s)
      Takaaki Akaike
    • Organizer
      3rd STINT-JSPS Redox Biology Conference (Stockholm)
    • Int'l Joint Research / Invited
  • [Presentation] The physiological functions of cyclic octa-sulfur (S8) formed endogenously in diverse organisms including mammals2022

    • Author(s)
      Takaaki Akaike
    • Organizer
      Redox week in Sendai 2022 (Sendai)
    • Int'l Joint Research / Invited
  • [Presentation] Sulfur biology and redox signaling in energy metabolism, infection, and immunity2022

    • Author(s)
      Takaaki Akaike
    • Organizer
      The 15th Korea-Japan International Symposium on Microbiology (Korea)
    • Int'l Joint Research / Invited
  • [Presentation] 呼気オミックスから空間バイオミックスへの新展開2022

    • Author(s)
      赤池孝章
    • Organizer
      レドックス R&D 戦略委員会第3回企画シンポジウム
    • Invited
  • [Presentation] Cyclo-octasulfur, S8, formed endogenously in mammals: its biosynthesis and physiological functions2022

    • Author(s)
      Takaaki Akaike
    • Organizer
      GRC “Thiol-Based Redox Regulation and Signaling: The Chemical Biology of Sulfur”
    • Int'l Joint Research / Invited
  • [Presentation] Reactive persulfide regulation of redox signaling and immune response2022

    • Author(s)
      Takaaki Akaike
    • Organizer
      6th World Congress on Hydrogen Sulfide in Biology & Medicine Keynote Lecture, Molecular Mechanisms (online)
    • Int'l Joint Research / Invited
  • [Book] 呼吸器疾患最新の治療2025-2026(超硫黄分子による呼吸器疾患制御と呼気オミックス)2024

    • Author(s)
      緒方星陵, 松永哲郎, 赤池孝章
    • Total Pages
      6
    • Publisher
      南江堂
  • [Book] 酸化ストレスの医学 改訂第3版(超硫黄分子の化学と生理機能)2024

    • Author(s)
      緒方星陵, Uladzimir Barayeu, 赤池孝章
    • Total Pages
      7
    • Publisher
      診断と治療社
  • [Book] メディカルサイエンスダイジェスト([特集]環境化学物質と生体応答)2023

    • Author(s)
      赤池孝章
    • Total Pages
      56
    • Publisher
      ニューサイエンス社
  • [Book] メディカルサイエンスダイジェスト(環境物質と生命の起源:超硫黄生物学プロローグ)2023

    • Author(s)
      松永哲郎, 赤池孝章
    • Total Pages
      5
    • Publisher
      ニューサイエンス社
  • [Book] Sulfurtransferases(A persulfide shield)2023

    • Author(s)
      Hamid Hisyam Abdul、Takata Tsuyoshi、Matsunaga Tetsuro、Akaike Takaaki
    • Total Pages
      16
    • Publisher
      Elsevier
  • [Remarks] 東北大学大学院医学系研究科環境医学分野ホームページ

    • URL

      http://www.toxicosci.med.tohoku.ac.jp/index.html

  • [Remarks] Research Mapマイポータル

    • URL

      https://researchmap.jp/AkaikeT

  • [Remarks] 「島津製作所×東北大学 超硫黄生命科学共創研究所」を設置

    • URL

      https://www.tohoku.ac.jp/japanese/2024/03/press20240313-04-shimazu.html

  • [Remarks] 「超硫黄分子」の寿命延長効果を発見 ~新たなサプリメントや健康法の開発に期待~

    • URL

      https://www.tohoku.ac.jp/japanese/2024/01/press20240119-01-supersulfides.html

  • [Patent(Industrial Property Rights)] 活性硫黄の定量方法2022

    • Inventor(s)
      國澤研大,遠山敦 彦,赤池孝章,飯伏 翼
    • Industrial Property Rights Holder
      國澤研大,遠山敦 彦,赤池孝章,飯伏 翼
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願 2022-209942
  • [Patent(Industrial Property Rights)] 感染症のバイオマーカ2022

    • Inventor(s)
      赤池孝章
    • Industrial Property Rights Holder
      赤池孝章
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      特願 2021-084723
    • Overseas
  • [Funded Workshop] The 1st International G-ReXS Conference in Sendai2024

  • [Funded Workshop] Redox Week in Sendai 20222022

URL: 

Published: 2024-12-25  

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